Incidental Mutation 'IGL02604:Vmn2r109'
| ID |
300164 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r109
|
| Ensembl Gene |
ENSMUSG00000090572 |
| Gene Name |
vomeronasal 2, receptor 109 |
| Synonyms |
EG627814 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
IGL02604
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
20540517-20564756 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 20540701 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 798
(H798L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132641
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167093]
|
| AlphaFold |
K7N747 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000167093
AA Change: H798L
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
AA Change: H798L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
1.4e-35 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
3.1e-21 |
PFAM |
|
Pfam:7tm_3
|
596 |
831 |
7.4e-52 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 52 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2300002M23Rik |
T |
C |
17: 35,567,948 (GRCm38) |
V61A |
probably benign |
Het |
| Arfgef1 |
G |
A |
1: 10,181,050 (GRCm38) |
|
probably benign |
Het |
| Arhgef4 |
T |
A |
1: 34,811,723 (GRCm38) |
L594* |
probably null |
Het |
| Cacna2d3 |
T |
C |
14: 29,293,109 (GRCm38) |
T375A |
possibly damaging |
Het |
| Calb2 |
A |
C |
8: 110,148,528 (GRCm38) |
Y155D |
probably damaging |
Het |
| Camkmt |
A |
G |
17: 85,096,625 (GRCm38) |
T92A |
possibly damaging |
Het |
| Chsy3 |
A |
G |
18: 59,409,115 (GRCm38) |
S442G |
probably benign |
Het |
| Cyp4f13 |
T |
C |
17: 32,932,421 (GRCm38) |
I173V |
probably benign |
Het |
| Dapk1 |
A |
G |
13: 60,748,320 (GRCm38) |
T741A |
probably benign |
Het |
| Dennd3 |
T |
C |
15: 73,556,403 (GRCm38) |
I866T |
probably damaging |
Het |
| Dhrs2 |
A |
T |
14: 55,237,321 (GRCm38) |
I138F |
possibly damaging |
Het |
| Dscaml1 |
C |
T |
9: 45,744,328 (GRCm38) |
|
probably benign |
Het |
| Fsbp |
A |
G |
4: 11,584,147 (GRCm38) |
E282G |
probably damaging |
Het |
| Hpgds |
A |
T |
6: 65,123,610 (GRCm38) |
L128Q |
probably damaging |
Het |
| Hspa9 |
A |
G |
18: 34,954,213 (GRCm38) |
V13A |
unknown |
Het |
| Itgb3 |
A |
G |
11: 104,662,443 (GRCm38) |
E709G |
probably damaging |
Het |
| Jarid2 |
T |
C |
13: 44,874,401 (GRCm38) |
S148P |
probably damaging |
Het |
| Kcna6 |
C |
T |
6: 126,739,204 (GRCm38) |
G241R |
probably benign |
Het |
| Kdm5a |
T |
A |
6: 120,431,980 (GRCm38) |
N1541K |
probably benign |
Het |
| Kel |
C |
A |
6: 41,687,582 (GRCm38) |
E640D |
probably damaging |
Het |
| Lcp1 |
A |
T |
14: 75,224,126 (GRCm38) |
I520F |
probably benign |
Het |
| Lgr4 |
A |
G |
2: 110,011,313 (GRCm38) |
I524V |
probably damaging |
Het |
| Maats1 |
A |
G |
16: 38,321,559 (GRCm38) |
|
probably benign |
Het |
| Mup20 |
A |
C |
4: 62,051,904 (GRCm38) |
Y139D |
probably damaging |
Het |
| Notch4 |
T |
C |
17: 34,565,388 (GRCm38) |
|
probably null |
Het |
| Obox7 |
A |
G |
7: 14,665,368 (GRCm38) |
E173G |
probably benign |
Het |
| Olfr1502 |
T |
A |
19: 13,861,806 (GRCm38) |
N4K |
probably benign |
Het |
| Olfr153 |
A |
T |
2: 87,532,605 (GRCm38) |
T191S |
probably damaging |
Het |
| Olfr447 |
T |
A |
6: 42,912,058 (GRCm38) |
C178* |
probably null |
Het |
| Olfr517 |
T |
A |
7: 108,868,650 (GRCm38) |
Y168F |
probably benign |
Het |
| Olfr889 |
C |
T |
9: 38,115,852 (GRCm38) |
Q19* |
probably null |
Het |
| Patl2 |
T |
G |
2: 122,125,333 (GRCm38) |
T241P |
possibly damaging |
Het |
| Pip5k1c |
C |
A |
10: 81,317,321 (GRCm38) |
|
probably null |
Het |
| Plekhg6 |
T |
C |
6: 125,377,379 (GRCm38) |
|
probably benign |
Het |
| Pon1 |
C |
A |
6: 5,168,375 (GRCm38) |
G344V |
probably damaging |
Het |
| Ppp1r21 |
G |
T |
17: 88,572,743 (GRCm38) |
K529N |
probably benign |
Het |
| Prdm15 |
A |
G |
16: 97,821,942 (GRCm38) |
S203P |
probably benign |
Het |
| Psmc2 |
T |
A |
5: 21,795,100 (GRCm38) |
|
probably null |
Het |
| Ptn |
T |
C |
6: 36,715,718 (GRCm38) |
M166V |
unknown |
Het |
| Ptpn13 |
A |
G |
5: 103,501,903 (GRCm38) |
N391D |
probably benign |
Het |
| Rnf214 |
A |
G |
9: 45,869,543 (GRCm38) |
S383P |
probably damaging |
Het |
| Rufy4 |
T |
A |
1: 74,134,189 (GRCm38) |
L438H |
probably damaging |
Het |
| Scarf2 |
A |
G |
16: 17,803,744 (GRCm38) |
T353A |
probably damaging |
Het |
| Serpinb9e |
A |
C |
13: 33,257,759 (GRCm38) |
I225L |
probably benign |
Het |
| Slc25a40 |
T |
C |
5: 8,453,219 (GRCm38) |
V312A |
probably benign |
Het |
| Tmc3 |
A |
G |
7: 83,622,619 (GRCm38) |
Y993C |
possibly damaging |
Het |
| Trim56 |
A |
C |
5: 137,113,076 (GRCm38) |
C529G |
probably damaging |
Het |
| Trim8 |
T |
C |
19: 46,515,478 (GRCm38) |
S490P |
probably damaging |
Het |
| Trmt6 |
A |
T |
2: 132,810,437 (GRCm38) |
Y147* |
probably null |
Het |
| Vps35 |
A |
G |
8: 85,286,389 (GRCm38) |
L153P |
probably damaging |
Het |
| Wdr82 |
T |
C |
9: 106,183,681 (GRCm38) |
I131T |
probably damaging |
Het |
| Zfp69 |
A |
T |
4: 120,931,463 (GRCm38) |
D218E |
probably benign |
Het |
|
| Other mutations in Vmn2r109 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01313:Vmn2r109
|
APN |
17 |
20,550,157 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01383:Vmn2r109
|
APN |
17 |
20,541,121 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
IGL01469:Vmn2r109
|
APN |
17 |
20,541,409 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01762:Vmn2r109
|
APN |
17 |
20,554,392 (GRCm38) |
missense |
probably benign |
|
|
IGL01864:Vmn2r109
|
APN |
17 |
20,541,134 (GRCm38) |
missense |
probably benign |
0.28 |
|
IGL02028:Vmn2r109
|
APN |
17 |
20,541,080 (GRCm38) |
missense |
probably benign |
0.28 |
|
IGL02074:Vmn2r109
|
APN |
17 |
20,554,341 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL02162:Vmn2r109
|
APN |
17 |
20,554,160 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02474:Vmn2r109
|
APN |
17 |
20,540,888 (GRCm38) |
missense |
probably benign |
|
|
IGL02490:Vmn2r109
|
APN |
17 |
20,540,984 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL02669:Vmn2r109
|
APN |
17 |
20,554,256 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
IGL02705:Vmn2r109
|
APN |
17 |
20,553,800 (GRCm38) |
missense |
probably benign |
|
|
IGL02745:Vmn2r109
|
APN |
17 |
20,541,250 (GRCm38) |
missense |
probably damaging |
0.99 |
|
PIT4142001:Vmn2r109
|
UTSW |
17 |
20,554,577 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R0389:Vmn2r109
|
UTSW |
17 |
20,541,074 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0470:Vmn2r109
|
UTSW |
17 |
20,552,886 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0570:Vmn2r109
|
UTSW |
17 |
20,540,675 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0855:Vmn2r109
|
UTSW |
17 |
20,541,408 (GRCm38) |
nonsense |
probably null |
|
|
R0882:Vmn2r109
|
UTSW |
17 |
20,554,580 (GRCm38) |
splice site |
probably benign |
|
|
R1241:Vmn2r109
|
UTSW |
17 |
20,555,241 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R1587:Vmn2r109
|
UTSW |
17 |
20,540,740 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1931:Vmn2r109
|
UTSW |
17 |
20,553,810 (GRCm38) |
nonsense |
probably null |
|
|
R1957:Vmn2r109
|
UTSW |
17 |
20,564,707 (GRCm38) |
missense |
probably benign |
0.11 |
|
R1962:Vmn2r109
|
UTSW |
17 |
20,553,923 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2020:Vmn2r109
|
UTSW |
17 |
20,541,186 (GRCm38) |
nonsense |
probably null |
|
|
R2073:Vmn2r109
|
UTSW |
17 |
20,564,712 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2436:Vmn2r109
|
UTSW |
17 |
20,554,536 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3123:Vmn2r109
|
UTSW |
17 |
20,540,986 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3839:Vmn2r109
|
UTSW |
17 |
20,554,442 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4019:Vmn2r109
|
UTSW |
17 |
20,553,812 (GRCm38) |
missense |
probably benign |
|
|
R4428:Vmn2r109
|
UTSW |
17 |
20,553,024 (GRCm38) |
missense |
probably benign |
|
|
R4584:Vmn2r109
|
UTSW |
17 |
20,554,558 (GRCm38) |
nonsense |
probably null |
|
|
R4652:Vmn2r109
|
UTSW |
17 |
20,541,394 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r109
|
UTSW |
17 |
20,541,343 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4823:Vmn2r109
|
UTSW |
17 |
20,553,891 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4831:Vmn2r109
|
UTSW |
17 |
20,541,232 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4907:Vmn2r109
|
UTSW |
17 |
20,550,086 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5011:Vmn2r109
|
UTSW |
17 |
20,555,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5296:Vmn2r109
|
UTSW |
17 |
20,554,341 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R5600:Vmn2r109
|
UTSW |
17 |
20,540,927 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5602:Vmn2r109
|
UTSW |
17 |
20,540,671 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5652:Vmn2r109
|
UTSW |
17 |
20,540,519 (GRCm38) |
makesense |
probably null |
|
|
R5702:Vmn2r109
|
UTSW |
17 |
20,554,145 (GRCm38) |
missense |
probably benign |
0.42 |
|
R5706:Vmn2r109
|
UTSW |
17 |
20,554,305 (GRCm38) |
missense |
probably benign |
0.16 |
|
R5714:Vmn2r109
|
UTSW |
17 |
20,552,859 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5832:Vmn2r109
|
UTSW |
17 |
20,541,056 (GRCm38) |
missense |
probably benign |
0.10 |
|
R6008:Vmn2r109
|
UTSW |
17 |
20,540,719 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6334:Vmn2r109
|
UTSW |
17 |
20,541,178 (GRCm38) |
missense |
probably benign |
0.18 |
|
R6377:Vmn2r109
|
UTSW |
17 |
20,564,534 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6738:Vmn2r109
|
UTSW |
17 |
20,554,523 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R6857:Vmn2r109
|
UTSW |
17 |
20,540,670 (GRCm38) |
missense |
probably benign |
0.45 |
|
R6953:Vmn2r109
|
UTSW |
17 |
20,540,711 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R7108:Vmn2r109
|
UTSW |
17 |
20,564,744 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7229:Vmn2r109
|
UTSW |
17 |
20,540,963 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R7238:Vmn2r109
|
UTSW |
17 |
20,541,074 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7244:Vmn2r109
|
UTSW |
17 |
20,540,683 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R7292:Vmn2r109
|
UTSW |
17 |
20,541,438 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7354:Vmn2r109
|
UTSW |
17 |
20,540,781 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7357:Vmn2r109
|
UTSW |
17 |
20,541,274 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7522:Vmn2r109
|
UTSW |
17 |
20,554,403 (GRCm38) |
missense |
probably benign |
0.11 |
|
R7596:Vmn2r109
|
UTSW |
17 |
20,540,680 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7728:Vmn2r109
|
UTSW |
17 |
20,552,855 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7859:Vmn2r109
|
UTSW |
17 |
20,541,174 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7871:Vmn2r109
|
UTSW |
17 |
20,540,520 (GRCm38) |
missense |
probably benign |
0.08 |
|
R8113:Vmn2r109
|
UTSW |
17 |
20,554,467 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8153:Vmn2r109
|
UTSW |
17 |
20,564,707 (GRCm38) |
missense |
probably benign |
0.11 |
|
R8977:Vmn2r109
|
UTSW |
17 |
20,554,269 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R9687:Vmn2r109
|
UTSW |
17 |
20,555,070 (GRCm38) |
missense |
|
|
|
Z1176:Vmn2r109
|
UTSW |
17 |
20,552,994 (GRCm38) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation