Incidental Mutation 'IGL02604:Trmt6'
ID 300189
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trmt6
Ensembl Gene ENSMUSG00000037376
Gene Name tRNA methyltransferase 6
Synonyms 3300001M20Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.945) question?
Stock # IGL02604
Quality Score
Status
Chromosome 2
Chromosomal Location 132646127-132657975 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 132652357 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 147 (Y147*)
Ref Sequence ENSEMBL: ENSMUSP00000044687 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039554]
AlphaFold Q8CE96
Predicted Effect probably null
Transcript: ENSMUST00000039554
AA Change: Y147*
SMART Domains Protein: ENSMUSP00000044687
Gene: ENSMUSG00000037376
AA Change: Y147*

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
Pfam:Gcd10p 20 302 7.2e-74 PFAM
coiled coil region 345 364 N/A INTRINSIC
low complexity region 444 456 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127855
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136897
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145117
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147336
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152836
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300002M23Rik T C 17: 35,878,845 (GRCm39) V61A probably benign Het
Arfgef1 G A 1: 10,251,275 (GRCm39) probably benign Het
Arhgef4 T A 1: 34,850,804 (GRCm39) L594* probably null Het
Cacna2d3 T C 14: 29,015,066 (GRCm39) T375A possibly damaging Het
Calb2 A C 8: 110,875,160 (GRCm39) Y155D probably damaging Het
Camkmt A G 17: 85,404,053 (GRCm39) T92A possibly damaging Het
Cfap91 A G 16: 38,141,921 (GRCm39) probably benign Het
Chsy3 A G 18: 59,542,187 (GRCm39) S442G probably benign Het
Cyp4f13 T C 17: 33,151,395 (GRCm39) I173V probably benign Het
Dapk1 A G 13: 60,896,134 (GRCm39) T741A probably benign Het
Dennd3 T C 15: 73,428,252 (GRCm39) I866T probably damaging Het
Dhrs2 A T 14: 55,474,778 (GRCm39) I138F possibly damaging Het
Dscaml1 C T 9: 45,655,626 (GRCm39) probably benign Het
Fsbp A G 4: 11,584,147 (GRCm39) E282G probably damaging Het
Hpgds A T 6: 65,100,594 (GRCm39) L128Q probably damaging Het
Hspa9 A G 18: 35,087,266 (GRCm39) V13A unknown Het
Itgb3 A G 11: 104,553,269 (GRCm39) E709G probably damaging Het
Jarid2 T C 13: 45,027,877 (GRCm39) S148P probably damaging Het
Kcna6 C T 6: 126,716,167 (GRCm39) G241R probably benign Het
Kdm5a T A 6: 120,408,941 (GRCm39) N1541K probably benign Het
Kel C A 6: 41,664,516 (GRCm39) E640D probably damaging Het
Lcp1 A T 14: 75,461,566 (GRCm39) I520F probably benign Het
Lgr4 A G 2: 109,841,658 (GRCm39) I524V probably damaging Het
Mup20 A C 4: 61,970,141 (GRCm39) Y139D probably damaging Het
Notch4 T C 17: 34,784,362 (GRCm39) probably null Het
Obox7 A G 7: 14,399,293 (GRCm39) E173G probably benign Het
Or10a49 T A 7: 108,467,857 (GRCm39) Y168F probably benign Het
Or2a25 T A 6: 42,888,992 (GRCm39) C178* probably null Het
Or5w22 A T 2: 87,362,949 (GRCm39) T191S probably damaging Het
Or8b40 C T 9: 38,027,148 (GRCm39) Q19* probably null Het
Or9i1 T A 19: 13,839,170 (GRCm39) N4K probably benign Het
Patl2 T G 2: 121,955,814 (GRCm39) T241P possibly damaging Het
Pip5k1c C A 10: 81,153,155 (GRCm39) probably null Het
Plekhg6 T C 6: 125,354,342 (GRCm39) probably benign Het
Pon1 C A 6: 5,168,375 (GRCm39) G344V probably damaging Het
Ppp1r21 G T 17: 88,880,171 (GRCm39) K529N probably benign Het
Prdm15 A G 16: 97,623,142 (GRCm39) S203P probably benign Het
Psmc2 T A 5: 22,000,098 (GRCm39) probably null Het
Ptn T C 6: 36,692,653 (GRCm39) M166V unknown Het
Ptpn13 A G 5: 103,649,769 (GRCm39) N391D probably benign Het
Rnf214 A G 9: 45,780,841 (GRCm39) S383P probably damaging Het
Rufy4 T A 1: 74,173,348 (GRCm39) L438H probably damaging Het
Scarf2 A G 16: 17,621,608 (GRCm39) T353A probably damaging Het
Serpinb9e A C 13: 33,441,742 (GRCm39) I225L probably benign Het
Slc25a40 T C 5: 8,503,219 (GRCm39) V312A probably benign Het
Tmc3 A G 7: 83,271,827 (GRCm39) Y993C possibly damaging Het
Trim56 A C 5: 137,141,930 (GRCm39) C529G probably damaging Het
Trim8 T C 19: 46,503,917 (GRCm39) S490P probably damaging Het
Vmn2r109 T A 17: 20,760,963 (GRCm39) H798L probably damaging Het
Vps35 A G 8: 86,013,018 (GRCm39) L153P probably damaging Het
Wdr82 T C 9: 106,060,880 (GRCm39) I131T probably damaging Het
Zfp69 A T 4: 120,788,660 (GRCm39) D218E probably benign Het
Other mutations in Trmt6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02314:Trmt6 APN 2 132,647,378 (GRCm39) missense probably benign 0.01
IGL03216:Trmt6 APN 2 132,650,618 (GRCm39) missense probably null
IGL03231:Trmt6 APN 2 132,657,756 (GRCm39) missense probably benign 0.01
R0060:Trmt6 UTSW 2 132,648,689 (GRCm39) missense possibly damaging 0.84
R0060:Trmt6 UTSW 2 132,648,689 (GRCm39) missense possibly damaging 0.84
R0086:Trmt6 UTSW 2 132,650,937 (GRCm39) critical splice acceptor site probably benign
R0485:Trmt6 UTSW 2 132,650,950 (GRCm39) splice site probably benign
R0827:Trmt6 UTSW 2 132,657,754 (GRCm39) missense probably damaging 1.00
R1654:Trmt6 UTSW 2 132,657,755 (GRCm39) missense possibly damaging 0.92
R1757:Trmt6 UTSW 2 132,652,157 (GRCm39) missense probably damaging 0.96
R1974:Trmt6 UTSW 2 132,652,968 (GRCm39) missense probably damaging 1.00
R2008:Trmt6 UTSW 2 132,648,829 (GRCm39) nonsense probably null
R2310:Trmt6 UTSW 2 132,650,832 (GRCm39) missense probably damaging 1.00
R4989:Trmt6 UTSW 2 132,650,191 (GRCm39) missense possibly damaging 0.58
R5288:Trmt6 UTSW 2 132,650,703 (GRCm39) missense probably benign 0.03
R5385:Trmt6 UTSW 2 132,650,703 (GRCm39) missense probably benign 0.03
R5386:Trmt6 UTSW 2 132,650,703 (GRCm39) missense probably benign 0.03
R6546:Trmt6 UTSW 2 132,654,073 (GRCm39) missense probably benign 0.16
R6815:Trmt6 UTSW 2 132,651,778 (GRCm39) missense probably damaging 1.00
R7992:Trmt6 UTSW 2 132,652,959 (GRCm39) missense probably damaging 1.00
R8016:Trmt6 UTSW 2 132,651,826 (GRCm39) missense probably damaging 1.00
R9445:Trmt6 UTSW 2 132,650,774 (GRCm39) missense probably benign 0.23
R9446:Trmt6 UTSW 2 132,650,774 (GRCm39) missense probably benign 0.23
R9482:Trmt6 UTSW 2 132,648,699 (GRCm39) missense probably benign 0.04
R9639:Trmt6 UTSW 2 132,650,862 (GRCm39) nonsense probably null
Posted On 2015-04-16