Incidental Mutation 'IGL02605:Tas2r122'
ID300240
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r122
Ensembl Gene ENSMUSG00000078280
Gene Nametaste receptor, type 2, member 122
SynonymsTas2r22, T2R22, mGR22
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.048) question?
Stock #IGL02605
Quality Score
Status
Chromosome6
Chromosomal Location132710999-132711928 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 132711609 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 107 (Y107C)
Ref Sequence ENSEMBL: ENSMUSP00000100699 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105077]
Predicted Effect probably damaging
Transcript: ENSMUST00000105077
AA Change: Y107C

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000100699
Gene: ENSMUSG00000078280
AA Change: Y107C

DomainStartEndE-ValueType
Pfam:TAS2R 1 302 2.3e-73 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb2 A T 2: 103,717,257 Y992F probably benign Het
Adgrg6 T A 10: 14,467,232 N324Y probably damaging Het
Ampd3 T C 7: 110,795,758 F305L probably benign Het
Ankrd35 A G 3: 96,681,072 probably null Het
Api5 A G 2: 94,429,719 I64T possibly damaging Het
Arhgap21 A G 2: 20,855,588 I1165T probably damaging Het
Bdp1 T C 13: 100,078,115 probably null Het
Capn3 T A 2: 120,496,037 I570N probably damaging Het
Catsperg2 T C 7: 29,719,565 H232R possibly damaging Het
Clcn7 T C 17: 25,146,818 L156P possibly damaging Het
Cpa3 C A 3: 20,222,212 V286F probably benign Het
Csrnp3 G A 2: 66,022,809 C527Y probably damaging Het
Dock5 A T 14: 67,828,438 V372E probably benign Het
Elmo1 T C 13: 20,605,202 L696P probably damaging Het
Fam91a1 T C 15: 58,431,196 probably benign Het
Gm12695 T A 4: 96,762,751 D155V probably null Het
Hspa4l A G 3: 40,781,623 I559V probably benign Het
Kdm1a G T 4: 136,551,037 probably benign Het
Lrrc8d A T 5: 105,826,817 noncoding transcript Het
Minpp1 A T 19: 32,498,415 Y316F possibly damaging Het
Neto2 T C 8: 85,663,435 probably benign Het
Nrxn2 T A 19: 6,450,580 D277E probably benign Het
Ola1 A G 2: 73,142,300 probably benign Het
Olfr1298 A G 2: 111,645,505 V164A probably benign Het
Olfr550 T C 7: 102,579,395 I300T probably damaging Het
Olfr893 T A 9: 38,209,236 M61K probably damaging Het
Pam A G 1: 97,840,339 V722A possibly damaging Het
Pfdn6 T C 17: 33,939,103 Y90C probably benign Het
Pkhd1 T A 1: 20,550,902 H844L possibly damaging Het
Plk5 G A 10: 80,363,062 V422M probably damaging Het
Psmc1 G T 12: 100,119,127 R249L probably damaging Het
Ptpro C T 6: 137,380,318 P269L probably benign Het
Ralgapa1 G T 12: 55,712,665 H1480Q possibly damaging Het
Rars G A 11: 35,824,526 probably benign Het
Rbm48 G A 5: 3,590,600 R260C possibly damaging Het
Smarcc1 C T 9: 110,222,000 H963Y possibly damaging Het
Spef2 T C 15: 9,725,152 E230G probably damaging Het
Spg11 A G 2: 122,092,260 S903P probably benign Het
Tpm3 C A 3: 90,088,446 N204K probably benign Het
Wdr36 T C 18: 32,851,991 I450T possibly damaging Het
Other mutations in Tas2r122
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01712:Tas2r122 APN 6 132711762 missense possibly damaging 0.87
IGL02478:Tas2r122 APN 6 132711615 missense possibly damaging 0.81
IGL02646:Tas2r122 APN 6 132711790 missense probably damaging 1.00
IGL02716:Tas2r122 APN 6 132711264 missense probably damaging 1.00
R0318:Tas2r122 UTSW 6 132711832 missense possibly damaging 0.90
R0462:Tas2r122 UTSW 6 132711178 missense probably benign 0.06
R0532:Tas2r122 UTSW 6 132711828 missense possibly damaging 0.94
R0538:Tas2r122 UTSW 6 132711815 missense probably benign 0.06
R0570:Tas2r122 UTSW 6 132711811 missense probably damaging 1.00
R1863:Tas2r122 UTSW 6 132711102 nonsense probably null
R1966:Tas2r122 UTSW 6 132711194 nonsense probably null
R2001:Tas2r122 UTSW 6 132711622 missense possibly damaging 0.91
R3500:Tas2r122 UTSW 6 132711560 missense probably damaging 1.00
R3871:Tas2r122 UTSW 6 132711580 missense probably benign 0.00
R4174:Tas2r122 UTSW 6 132711876 missense probably damaging 0.96
R5533:Tas2r122 UTSW 6 132711430 missense probably damaging 1.00
R5567:Tas2r122 UTSW 6 132711372 missense probably benign 0.28
R6455:Tas2r122 UTSW 6 132711663 nonsense probably null
R6716:Tas2r122 UTSW 6 132711897 missense probably damaging 0.98
Posted On2015-04-16