Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02605:Tas2r122'

300240

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r122

Ensembl Gene

ENSMUSG00000078280

Gene Name

taste receptor, type 2, member 122

Synonyms

Tas2r22, T2R22, mGR22

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.048) question?

Stock #

IGL02605

Quality Score

Status

Chromosome

Chromosomal Location

132710999-132711928 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 132711609 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 107 (Y107C)

Ref Sequence

ENSEMBL: ENSMUSP00000100699 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105077]

Predicted Effect

probably damaging
Transcript: ENSMUST00000105077
AA Change: Y107C

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000100699
Gene: ENSMUSG00000078280
AA Change: Y107C

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	302	2.3e-73	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abtb2	A	T	2: 103,717,257	Y992F	probably benign	Het
Adgrg6	T	A	10: 14,467,232	N324Y	probably damaging	Het
Ampd3	T	C	7: 110,795,758	F305L	probably benign	Het
Ankrd35	A	G	3: 96,681,072		probably null	Het
Api5	A	G	2: 94,429,719	I64T	possibly damaging	Het
Arhgap21	A	G	2: 20,855,588	I1165T	probably damaging	Het
Bdp1	T	C	13: 100,078,115		probably null	Het
Capn3	T	A	2: 120,496,037	I570N	probably damaging	Het
Catsperg2	T	C	7: 29,719,565	H232R	possibly damaging	Het
Clcn7	T	C	17: 25,146,818	L156P	possibly damaging	Het
Cpa3	C	A	3: 20,222,212	V286F	probably benign	Het
Csrnp3	G	A	2: 66,022,809	C527Y	probably damaging	Het
Dock5	A	T	14: 67,828,438	V372E	probably benign	Het
Elmo1	T	C	13: 20,605,202	L696P	probably damaging	Het
Fam91a1	T	C	15: 58,431,196		probably benign	Het
Gm12695	T	A	4: 96,762,751	D155V	probably null	Het
Hspa4l	A	G	3: 40,781,623	I559V	probably benign	Het
Kdm1a	G	T	4: 136,551,037		probably benign	Het
Lrrc8d	A	T	5: 105,826,817		noncoding transcript	Het
Minpp1	A	T	19: 32,498,415	Y316F	possibly damaging	Het
Neto2	T	C	8: 85,663,435		probably benign	Het
Nrxn2	T	A	19: 6,450,580	D277E	probably benign	Het
Ola1	A	G	2: 73,142,300		probably benign	Het
Olfr1298	A	G	2: 111,645,505	V164A	probably benign	Het
Olfr550	T	C	7: 102,579,395	I300T	probably damaging	Het
Olfr893	T	A	9: 38,209,236	M61K	probably damaging	Het
Pam	A	G	1: 97,840,339	V722A	possibly damaging	Het
Pfdn6	T	C	17: 33,939,103	Y90C	probably benign	Het
Pkhd1	T	A	1: 20,550,902	H844L	possibly damaging	Het
Plk5	G	A	10: 80,363,062	V422M	probably damaging	Het
Psmc1	G	T	12: 100,119,127	R249L	probably damaging	Het
Ptpro	C	T	6: 137,380,318	P269L	probably benign	Het
Ralgapa1	G	T	12: 55,712,665	H1480Q	possibly damaging	Het
Rars	G	A	11: 35,824,526		probably benign	Het
Rbm48	G	A	5: 3,590,600	R260C	possibly damaging	Het
Smarcc1	C	T	9: 110,222,000	H963Y	possibly damaging	Het
Spef2	T	C	15: 9,725,152	E230G	probably damaging	Het
Spg11	A	G	2: 122,092,260	S903P	probably benign	Het
Tpm3	C	A	3: 90,088,446	N204K	probably benign	Het
Wdr36	T	C	18: 32,851,991	I450T	possibly damaging	Het

Other mutations in Tas2r122

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01712:Tas2r122	APN	6	132711762	missense	possibly damaging	0.87
IGL02478:Tas2r122	APN	6	132711615	missense	possibly damaging	0.81
IGL02646:Tas2r122	APN	6	132711790	missense	probably damaging	1.00
IGL02716:Tas2r122	APN	6	132711264	missense	probably damaging	1.00
R0318:Tas2r122	UTSW	6	132711832	missense	possibly damaging	0.90
R0462:Tas2r122	UTSW	6	132711178	missense	probably benign	0.06
R0532:Tas2r122	UTSW	6	132711828	missense	possibly damaging	0.94
R0538:Tas2r122	UTSW	6	132711815	missense	probably benign	0.06
R0570:Tas2r122	UTSW	6	132711811	missense	probably damaging	1.00
R1863:Tas2r122	UTSW	6	132711102	nonsense	probably null
R1966:Tas2r122	UTSW	6	132711194	nonsense	probably null
R2001:Tas2r122	UTSW	6	132711622	missense	possibly damaging	0.91
R3500:Tas2r122	UTSW	6	132711560	missense	probably damaging	1.00
R3871:Tas2r122	UTSW	6	132711580	missense	probably benign	0.00
R4174:Tas2r122	UTSW	6	132711876	missense	probably damaging	0.96
R5533:Tas2r122	UTSW	6	132711430	missense	probably damaging	1.00
R5567:Tas2r122	UTSW	6	132711372	missense	probably benign	0.28
R6455:Tas2r122	UTSW	6	132711663	nonsense	probably null
R6716:Tas2r122	UTSW	6	132711897	missense	probably damaging	0.98

Posted On

2015-04-16