Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02605:Ola1'

300248

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ola1

Ensembl Gene

ENSMUSG00000027108

Gene Name

Obg-like ATPase 1

Synonyms

2510025G09Rik, 2810409H07Rik, 2810405J23Rik, Gtpbp9

Accession Numbers

Is this an essential gene?

Possibly essential (E-score: 0.650) question?

Stock #

IGL02605

Quality Score

Status

Chromosome

Chromosomal Location

73092801-73218924 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 73142300 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000107686 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028517] [ENSMUST00000100015] [ENSMUST00000112055]

Predicted Effect

probably benign
Transcript: ENSMUST00000028517

SMART Domains

Protein: ENSMUSP00000028517
Gene: ENSMUSG00000027108

Domain	Start	End	E-Value	Type
low complexity region	2	17	N/A	INTRINSIC
Pfam:FeoB_N	23	74	2.2e-8	PFAM
Pfam:MMR_HSR1	24	164	1.2e-22	PFAM
Pfam:YchF-GTPase_C	305	388	9e-45	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000100015

SMART Domains

Protein: ENSMUSP00000097592
Gene: ENSMUSG00000027108

Domain	Start	End	E-Value	Type
low complexity region	2	17	N/A	INTRINSIC
Pfam:FeoB_N	23	74	1.4e-8	PFAM
Pfam:MMR_HSR1	24	231	5.6e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000112055

SMART Domains

Protein: ENSMUSP00000107686
Gene: ENSMUSG00000027108

Domain	Start	End	E-Value	Type
low complexity region	2	17	N/A	INTRINSIC
Pfam:FeoB_N	23	74	1.5e-7	PFAM
Pfam:MMR_HSR1	24	259	3.2e-18	PFAM
low complexity region	261	272	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152608

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]
PHENOTYPE: Mice homozygous for a null allele display partial neonatal lethality, embryonic developmental delay, delayed development of lung and liver, and reduced body size. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abtb2	A	T	2: 103,717,257	Y992F	probably benign	Het
Adgrg6	T	A	10: 14,467,232	N324Y	probably damaging	Het
Ampd3	T	C	7: 110,795,758	F305L	probably benign	Het
Ankrd35	A	G	3: 96,681,072		probably null	Het
Api5	A	G	2: 94,429,719	I64T	possibly damaging	Het
Arhgap21	A	G	2: 20,855,588	I1165T	probably damaging	Het
Bdp1	T	C	13: 100,078,115		probably null	Het
Capn3	T	A	2: 120,496,037	I570N	probably damaging	Het
Catsperg2	T	C	7: 29,719,565	H232R	possibly damaging	Het
Clcn7	T	C	17: 25,146,818	L156P	possibly damaging	Het
Cpa3	C	A	3: 20,222,212	V286F	probably benign	Het
Csrnp3	G	A	2: 66,022,809	C527Y	probably damaging	Het
Dock5	A	T	14: 67,828,438	V372E	probably benign	Het
Elmo1	T	C	13: 20,605,202	L696P	probably damaging	Het
Fam91a1	T	C	15: 58,431,196		probably benign	Het
Gm12695	T	A	4: 96,762,751	D155V	probably null	Het
Hspa4l	A	G	3: 40,781,623	I559V	probably benign	Het
Kdm1a	G	T	4: 136,551,037		probably benign	Het
Lrrc8d	A	T	5: 105,826,817		noncoding transcript	Het
Minpp1	A	T	19: 32,498,415	Y316F	possibly damaging	Het
Neto2	T	C	8: 85,663,435		probably benign	Het
Nrxn2	T	A	19: 6,450,580	D277E	probably benign	Het
Olfr1298	A	G	2: 111,645,505	V164A	probably benign	Het
Olfr550	T	C	7: 102,579,395	I300T	probably damaging	Het
Olfr893	T	A	9: 38,209,236	M61K	probably damaging	Het
Pam	A	G	1: 97,840,339	V722A	possibly damaging	Het
Pfdn6	T	C	17: 33,939,103	Y90C	probably benign	Het
Pkhd1	T	A	1: 20,550,902	H844L	possibly damaging	Het
Plk5	G	A	10: 80,363,062	V422M	probably damaging	Het
Psmc1	G	T	12: 100,119,127	R249L	probably damaging	Het
Ptpro	C	T	6: 137,380,318	P269L	probably benign	Het
Ralgapa1	G	T	12: 55,712,665	H1480Q	possibly damaging	Het
Rars	G	A	11: 35,824,526		probably benign	Het
Rbm48	G	A	5: 3,590,600	R260C	possibly damaging	Het
Smarcc1	C	T	9: 110,222,000	H963Y	possibly damaging	Het
Spef2	T	C	15: 9,725,152	E230G	probably damaging	Het
Spg11	A	G	2: 122,092,260	S903P	probably benign	Het
Tas2r122	T	C	6: 132,711,609	Y107C	probably damaging	Het
Tpm3	C	A	3: 90,088,446	N204K	probably benign	Het
Wdr36	T	C	18: 32,851,991	I450T	possibly damaging	Het

Other mutations in Ola1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00864:Ola1	APN	2	73156897	missense	probably benign	0.00
IGL01969:Ola1	APN	2	73100146	missense	probably benign	0.01
IGL02987:Ola1	APN	2	73156898	missense	probably benign	0.03
IGL03171:Ola1	APN	2	73156853	missense	probably benign	0.24
R0602:Ola1	UTSW	2	73093712	missense	probably damaging	1.00
R1167:Ola1	UTSW	2	73097194	missense	probably damaging	0.99
R1474:Ola1	UTSW	2	73156844	missense	probably damaging	1.00
R1650:Ola1	UTSW	2	73156894	missense	possibly damaging	0.65
R1781:Ola1	UTSW	2	73156755	missense	possibly damaging	0.92
R3732:Ola1	UTSW	2	73156860	missense	probably damaging	1.00
R3732:Ola1	UTSW	2	73156860	missense	probably damaging	1.00
R3733:Ola1	UTSW	2	73156860	missense	probably damaging	1.00
R3918:Ola1	UTSW	2	73142339	missense	probably benign	0.33
R4650:Ola1	UTSW	2	73141965	missense	probably damaging	1.00
R5304:Ola1	UTSW	2	73199434	missense	probably damaging	0.99
R5352:Ola1	UTSW	2	73099330	missense	probably damaging	0.99
R5918:Ola1	UTSW	2	73156784	missense	probably benign	0.18
R6062:Ola1	UTSW	2	73199498	missense	probably damaging	1.00
R6858:Ola1	UTSW	2	73097230	missense	probably damaging	0.97
R7077:Ola1	UTSW	2	73141964	missense	probably damaging	1.00
R8223:Ola1	UTSW	2	73099350	missense	probably damaging	1.00
R8343:Ola1	UTSW	2	73199401	missense	probably damaging	0.99

Posted On

2015-04-16