Incidental Mutation 'IGL02607:Vmn2r85'
ID300311
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r85
Ensembl Gene ENSMUSG00000092048
Gene Namevomeronasal 2, receptor 85
SynonymsEG623734
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.071) question?
Stock #IGL02607
Quality Score
Status
Chromosome10
Chromosomal Location130417772-130429612 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 130426421 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamic Acid at position 150 (K150E)
Ref Sequence ENSEMBL: ENSMUSP00000128792 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171811]
Predicted Effect possibly damaging
Transcript: ENSMUST00000171811
AA Change: K150E

PolyPhen 2 Score 0.895 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000128792
Gene: ENSMUSG00000092048
AA Change: K150E

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 77 425 9e-26 PFAM
Pfam:NCD3G 508 562 1.1e-18 PFAM
Pfam:7tm_3 595 831 3.7e-54 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110004E09Rik G A 16: 90,929,947 T98M probably damaging Het
Abca17 C T 17: 24,327,705 W307* probably null Het
Cit A G 5: 115,859,209 I84V probably benign Het
Cltc T C 11: 86,706,714 D1132G probably benign Het
Cobll1 A T 2: 65,151,085 S54T probably damaging Het
Dcstamp A G 15: 39,754,584 R130G possibly damaging Het
Dennd4a A G 9: 64,862,327 M439V probably damaging Het
Dnajc15 T A 14: 77,840,216 I110F probably damaging Het
Dock1 T C 7: 134,851,513 F824L probably benign Het
Eml2 A G 7: 19,206,111 H617R probably damaging Het
Fgd6 A T 10: 94,044,448 Q388L possibly damaging Het
Fkbp4 A T 6: 128,434,470 probably benign Het
Fmnl3 A T 15: 99,324,772 L431Q probably damaging Het
Gng8 T C 7: 16,894,934 probably benign Het
Hmcn1 T A 1: 150,744,995 I1155F possibly damaging Het
Muc4 G T 16: 32,775,819 C3135F possibly damaging Het
Mycbp2 C T 14: 103,285,273 G685D probably damaging Het
Olfr1389 T C 11: 49,430,512 F12S probably damaging Het
Pcdhb8 A T 18: 37,357,581 I771F probably benign Het
Pkn2 A G 3: 142,794,101 probably null Het
Rrn3 G T 16: 13,806,563 V420L possibly damaging Het
Samm50 A T 15: 84,207,838 Y338F probably benign Het
Slc2a7 C T 4: 150,154,705 T129I probably benign Het
Tbc1d8 T C 1: 39,379,511 I806V probably benign Het
Tex2 T C 11: 106,546,747 E699G unknown Het
Other mutations in Vmn2r85
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01160:Vmn2r85 APN 10 130418821 missense probably benign 0.22
IGL01298:Vmn2r85 APN 10 130418821 missense probably benign 0.22
IGL01361:Vmn2r85 APN 10 130418821 missense probably benign 0.22
IGL02185:Vmn2r85 APN 10 130418692 missense probably benign 0.13
IGL02505:Vmn2r85 APN 10 130425580 missense probably damaging 1.00
IGL02755:Vmn2r85 APN 10 130425512 missense probably damaging 0.98
IGL03188:Vmn2r85 APN 10 130418743 missense probably benign 0.16
IGL03366:Vmn2r85 APN 10 130426459 missense probably benign 0.00
IGL03397:Vmn2r85 APN 10 130425394 missense probably damaging 1.00
PIT4445001:Vmn2r85 UTSW 10 130425703 missense probably benign 0.00
R0066:Vmn2r85 UTSW 10 130425901 missense probably damaging 1.00
R0128:Vmn2r85 UTSW 10 130419185 splice site probably benign
R0130:Vmn2r85 UTSW 10 130419185 splice site probably benign
R0503:Vmn2r85 UTSW 10 130422740 missense probably damaging 1.00
R0827:Vmn2r85 UTSW 10 130429518 missense possibly damaging 0.89
R1432:Vmn2r85 UTSW 10 130425286 missense possibly damaging 0.74
R1521:Vmn2r85 UTSW 10 130425919 missense probably damaging 0.99
R2029:Vmn2r85 UTSW 10 130425574 nonsense probably null
R2034:Vmn2r85 UTSW 10 130426373 splice site probably benign
R2852:Vmn2r85 UTSW 10 130419166 missense probably benign 0.03
R2853:Vmn2r85 UTSW 10 130419166 missense probably benign 0.03
R3084:Vmn2r85 UTSW 10 130425212 missense probably benign 0.00
R3085:Vmn2r85 UTSW 10 130425212 missense probably benign 0.00
R3430:Vmn2r85 UTSW 10 130418889 missense probably damaging 0.97
R3694:Vmn2r85 UTSW 10 130418302 missense probably damaging 0.99
R3932:Vmn2r85 UTSW 10 130418467 missense probably damaging 1.00
R4207:Vmn2r85 UTSW 10 130418705 missense probably damaging 1.00
R4628:Vmn2r85 UTSW 10 130425366 missense probably benign 0.00
R4814:Vmn2r85 UTSW 10 130418698 missense probably benign 0.12
R4948:Vmn2r85 UTSW 10 130419121 missense probably damaging 1.00
R4951:Vmn2r85 UTSW 10 130425244 missense probably damaging 1.00
R4959:Vmn2r85 UTSW 10 130421433 missense probably damaging 1.00
R5336:Vmn2r85 UTSW 10 130422705 missense possibly damaging 0.63
R5643:Vmn2r85 UTSW 10 130426474 missense probably damaging 1.00
R6061:Vmn2r85 UTSW 10 130425662 missense probably benign 0.09
R6115:Vmn2r85 UTSW 10 130422803 missense probably damaging 1.00
R6190:Vmn2r85 UTSW 10 130425461 missense possibly damaging 0.88
R6518:Vmn2r85 UTSW 10 130429412 missense probably benign 0.00
R6533:Vmn2r85 UTSW 10 130426660 missense probably benign 0.00
R6610:Vmn2r85 UTSW 10 130425969 missense probably damaging 0.97
R6809:Vmn2r85 UTSW 10 130425926 missense probably benign
R6962:Vmn2r85 UTSW 10 130425583 missense probably damaging 0.99
R7075:Vmn2r85 UTSW 10 130422688 missense probably benign 0.06
R7104:Vmn2r85 UTSW 10 130426507 missense probably benign
R7424:Vmn2r85 UTSW 10 130418980 missense probably damaging 1.00
R7516:Vmn2r85 UTSW 10 130418983 missense probably damaging 1.00
R7537:Vmn2r85 UTSW 10 130422866 missense probably benign 0.01
R7768:Vmn2r85 UTSW 10 130418693 missense probably damaging 1.00
R7810:Vmn2r85 UTSW 10 130425212 missense probably benign 0.00
R8078:Vmn2r85 UTSW 10 130429495 nonsense probably null
R8115:Vmn2r85 UTSW 10 130425951 missense probably benign 0.06
R8262:Vmn2r85 UTSW 10 130418869 missense probably damaging 0.98
R8395:Vmn2r85 UTSW 10 130425928 missense probably damaging 0.99
R8409:Vmn2r85 UTSW 10 130425388 missense probably benign 0.16
R8547:Vmn2r85 UTSW 10 130425442 missense probably damaging 1.00
Z1176:Vmn2r85 UTSW 10 130425844 missense probably damaging 0.99
Z1177:Vmn2r85 UTSW 10 130418907 missense probably damaging 1.00
Posted On2015-04-16