Incidental Mutation 'IGL02607:Dnajc15'
ID300318
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dnajc15
Ensembl Gene ENSMUSG00000022013
Gene NameDnaJ heat shock protein family (Hsp40) member C15
SynonymsDnajd1, 1110003P16Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02607
Quality Score
Status
Chromosome14
Chromosomal Location77820681-77875125 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 77840216 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 110 (I110F)
Ref Sequence ENSEMBL: ENSMUSP00000154390 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022590] [ENSMUST00000226459]
Predicted Effect probably benign
Transcript: ENSMUST00000022590
SMART Domains Protein: ENSMUSP00000022590
Gene: ENSMUSG00000022013

DomainStartEndE-ValueType
low complexity region 34 53 N/A INTRINSIC
DnaJ 93 147 6.8e-7 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000226459
AA Change: I110F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227249
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased mitochondrial activity that results in rapid metabolism in fasted mice or mice fed a high fat diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110004E09Rik G A 16: 90,929,947 T98M probably damaging Het
Abca17 C T 17: 24,327,705 W307* probably null Het
Cit A G 5: 115,859,209 I84V probably benign Het
Cltc T C 11: 86,706,714 D1132G probably benign Het
Cobll1 A T 2: 65,151,085 S54T probably damaging Het
Dcstamp A G 15: 39,754,584 R130G possibly damaging Het
Dennd4a A G 9: 64,862,327 M439V probably damaging Het
Dock1 T C 7: 134,851,513 F824L probably benign Het
Eml2 A G 7: 19,206,111 H617R probably damaging Het
Fgd6 A T 10: 94,044,448 Q388L possibly damaging Het
Fkbp4 A T 6: 128,434,470 probably benign Het
Fmnl3 A T 15: 99,324,772 L431Q probably damaging Het
Gng8 T C 7: 16,894,934 probably benign Het
Hmcn1 T A 1: 150,744,995 I1155F possibly damaging Het
Muc4 G T 16: 32,775,819 C3135F possibly damaging Het
Mycbp2 C T 14: 103,285,273 G685D probably damaging Het
Olfr1389 T C 11: 49,430,512 F12S probably damaging Het
Pcdhb8 A T 18: 37,357,581 I771F probably benign Het
Pkn2 A G 3: 142,794,101 probably null Het
Rrn3 G T 16: 13,806,563 V420L possibly damaging Het
Samm50 A T 15: 84,207,838 Y338F probably benign Het
Slc2a7 C T 4: 150,154,705 T129I probably benign Het
Tbc1d8 T C 1: 39,379,511 I806V probably benign Het
Tex2 T C 11: 106,546,747 E699G unknown Het
Vmn2r85 T C 10: 130,426,421 K150E possibly damaging Het
Other mutations in Dnajc15
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0321:Dnajc15 UTSW 14 77874833 missense possibly damaging 0.90
R1574:Dnajc15 UTSW 14 77826414 missense probably benign 0.00
R1574:Dnajc15 UTSW 14 77826414 missense probably benign 0.00
R3774:Dnajc15 UTSW 14 77856937 critical splice donor site probably null
R4397:Dnajc15 UTSW 14 77874794 splice site probably null
R4747:Dnajc15 UTSW 14 77844456 missense probably benign 0.13
R5704:Dnajc15 UTSW 14 77826458 missense probably damaging 1.00
R7848:Dnajc15 UTSW 14 77840203 missense probably damaging 0.99
R8179:Dnajc15 UTSW 14 77852953 missense
Posted On2015-04-16