Incidental Mutation 'IGL02607:Dnajc15'
| ID |
300318 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Dnajc15
|
| Ensembl Gene |
ENSMUSG00000022013 |
| Gene Name |
DnaJ heat shock protein family (Hsp40) member C15 |
| Synonyms |
Dnajd1, 1110003P16Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02607
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
14 |
| Chromosomal Location |
78063657-78112357 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 78077656 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 110
(I110F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154390
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022590]
[ENSMUST00000226459]
|
| AlphaFold |
Q78YY6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000022590
|
| SMART Domains |
Protein: ENSMUSP00000022590
Gene: ENSMUSG00000022013
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
53 |
N/A |
INTRINSIC |
|
DnaJ
|
93 |
147 |
6.8e-7 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000226459
AA Change: I110F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000227249
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased mitochondrial activity that results in rapid metabolism in fasted mice or mice fed a high fat diet. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca17 |
C |
T |
17: 24,546,679 (GRCm39) |
W307* |
probably null |
Het |
| Cfap298 |
G |
A |
16: 90,726,835 (GRCm39) |
T98M |
probably damaging |
Het |
| Cit |
A |
G |
5: 115,997,268 (GRCm39) |
I84V |
probably benign |
Het |
| Cltc |
T |
C |
11: 86,597,540 (GRCm39) |
D1132G |
probably benign |
Het |
| Cobll1 |
A |
T |
2: 64,981,429 (GRCm39) |
S54T |
probably damaging |
Het |
| Dcstamp |
A |
G |
15: 39,617,980 (GRCm39) |
R130G |
possibly damaging |
Het |
| Dennd4a |
A |
G |
9: 64,769,609 (GRCm39) |
M439V |
probably damaging |
Het |
| Dock1 |
T |
C |
7: 134,453,242 (GRCm39) |
F824L |
probably benign |
Het |
| Eml2 |
A |
G |
7: 18,940,036 (GRCm39) |
H617R |
probably damaging |
Het |
| Fgd6 |
A |
T |
10: 93,880,310 (GRCm39) |
Q388L |
possibly damaging |
Het |
| Fkbp4 |
A |
T |
6: 128,411,433 (GRCm39) |
|
probably benign |
Het |
| Fmnl3 |
A |
T |
15: 99,222,653 (GRCm39) |
L431Q |
probably damaging |
Het |
| Gng8 |
T |
C |
7: 16,628,859 (GRCm39) |
|
probably benign |
Het |
| Hmcn1 |
T |
A |
1: 150,620,746 (GRCm39) |
I1155F |
possibly damaging |
Het |
| Muc4 |
G |
T |
16: 32,596,193 (GRCm39) |
C3135F |
possibly damaging |
Het |
| Mycbp2 |
C |
T |
14: 103,522,709 (GRCm39) |
G685D |
probably damaging |
Het |
| Or2y1d |
T |
C |
11: 49,321,339 (GRCm39) |
F12S |
probably damaging |
Het |
| Pcdhb8 |
A |
T |
18: 37,490,634 (GRCm39) |
I771F |
probably benign |
Het |
| Pkn2 |
A |
G |
3: 142,499,862 (GRCm39) |
|
probably null |
Het |
| Rrn3 |
G |
T |
16: 13,624,427 (GRCm39) |
V420L |
possibly damaging |
Het |
| Samm50 |
A |
T |
15: 84,092,039 (GRCm39) |
Y338F |
probably benign |
Het |
| Slc2a7 |
C |
T |
4: 150,239,162 (GRCm39) |
T129I |
probably benign |
Het |
| Tbc1d8 |
T |
C |
1: 39,418,592 (GRCm39) |
I806V |
probably benign |
Het |
| Tex2 |
T |
C |
11: 106,437,573 (GRCm39) |
E699G |
unknown |
Het |
| Vmn2r85 |
T |
C |
10: 130,262,290 (GRCm39) |
K150E |
possibly damaging |
Het |
|
| Other mutations in Dnajc15 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0321:Dnajc15
|
UTSW |
14 |
78,112,273 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1574:Dnajc15
|
UTSW |
14 |
78,063,854 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1574:Dnajc15
|
UTSW |
14 |
78,063,854 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3774:Dnajc15
|
UTSW |
14 |
78,094,377 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4397:Dnajc15
|
UTSW |
14 |
78,112,234 (GRCm39) |
splice site |
probably null |
|
|
R4747:Dnajc15
|
UTSW |
14 |
78,081,896 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5704:Dnajc15
|
UTSW |
14 |
78,063,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7848:Dnajc15
|
UTSW |
14 |
78,077,643 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8179:Dnajc15
|
UTSW |
14 |
78,090,393 (GRCm39) |
missense |
|
|
|
R8882:Dnajc15
|
UTSW |
14 |
78,094,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9260:Dnajc15
|
UTSW |
14 |
78,081,839 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
| Posted On |
2015-04-16 |
Incidental Mutation