Incidental Mutation 'IGL02607:Gng8'
ID300329
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gng8
Ensembl Gene ENSMUSG00000063594
Gene Nameguanine nucleotide binding protein (G protein), gamma 8
SynonymsG(y)8
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.293) question?
Stock #IGL02607
Quality Score
Status
Chromosome7
Chromosomal Location16891786-16895436 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 16894934 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000145567 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078182] [ENSMUST00000205459] [ENSMUST00000205716]
Predicted Effect probably benign
Transcript: ENSMUST00000078182
SMART Domains Protein: ENSMUSP00000077314
Gene: ENSMUSG00000063594

DomainStartEndE-ValueType
G_gamma 4 70 1.55e-22 SMART
GGL 8 70 8.6e-29 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205314
Predicted Effect probably benign
Transcript: ENSMUST00000205459
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205598
Predicted Effect probably benign
Transcript: ENSMUST00000205716
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205838
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206998
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous inactivation of this gene results in a slow but progressive loss of vomeronasal neurons, impairment of specific vomeronasal-mediated behaviors such as maternal and intermale aggression, and reduced physiological responses to pheromonal stimulation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110004E09Rik G A 16: 90,929,947 T98M probably damaging Het
Abca17 C T 17: 24,327,705 W307* probably null Het
Cit A G 5: 115,859,209 I84V probably benign Het
Cltc T C 11: 86,706,714 D1132G probably benign Het
Cobll1 A T 2: 65,151,085 S54T probably damaging Het
Dcstamp A G 15: 39,754,584 R130G possibly damaging Het
Dennd4a A G 9: 64,862,327 M439V probably damaging Het
Dnajc15 T A 14: 77,840,216 I110F probably damaging Het
Dock1 T C 7: 134,851,513 F824L probably benign Het
Eml2 A G 7: 19,206,111 H617R probably damaging Het
Fgd6 A T 10: 94,044,448 Q388L possibly damaging Het
Fkbp4 A T 6: 128,434,470 probably benign Het
Fmnl3 A T 15: 99,324,772 L431Q probably damaging Het
Hmcn1 T A 1: 150,744,995 I1155F possibly damaging Het
Muc4 G T 16: 32,775,819 C3135F possibly damaging Het
Mycbp2 C T 14: 103,285,273 G685D probably damaging Het
Olfr1389 T C 11: 49,430,512 F12S probably damaging Het
Pcdhb8 A T 18: 37,357,581 I771F probably benign Het
Pkn2 A G 3: 142,794,101 probably null Het
Rrn3 G T 16: 13,806,563 V420L possibly damaging Het
Samm50 A T 15: 84,207,838 Y338F probably benign Het
Slc2a7 C T 4: 150,154,705 T129I probably benign Het
Tbc1d8 T C 1: 39,379,511 I806V probably benign Het
Tex2 T C 11: 106,546,747 E699G unknown Het
Vmn2r85 T C 10: 130,426,421 K150E possibly damaging Het
Other mutations in Gng8
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0490:Gng8 UTSW 7 16894983 missense probably benign
R0494:Gng8 UTSW 7 16895288 missense probably benign
R1318:Gng8 UTSW 7 16895236 missense probably damaging 0.99
Posted On2015-04-16