Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02608:Tnfrsf22'

300344

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tnfrsf22

Ensembl Gene

ENSMUSG00000010751

Gene Name

tumor necrosis factor receptor superfamily, member 22

Synonyms

C130035G06Rik, mDcTrailr2, Tnfrh2, 2810028K06Rik, SOBa

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL02608

Quality Score

Status

Chromosome

Chromosomal Location

143188543-143203398 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 143198533 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 61 (K61*)

Ref Sequence

ENSEMBL: ENSMUSP00000119297 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075588] [ENSMUST00000084396] [ENSMUST00000146692]

AlphaFold

Q9ER62

Predicted Effect

probably null
Transcript: ENSMUST00000075588
AA Change: K61*

SMART Domains

Protein: ENSMUSP00000075018
Gene: ENSMUSG00000010751
AA Change: K61*

Domain	Start	End	E-Value	Type
transmembrane domain	15	34	N/A	INTRINSIC
TNFR	48	82	9.53e-2	SMART
TNFR	85	124	3.31e-10	SMART
TNFR	126	165	6.48e-4	SMART
transmembrane domain	177	196	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000084396
AA Change: K61*

SMART Domains

Protein: ENSMUSP00000081432
Gene: ENSMUSG00000010751
AA Change: K61*

Domain	Start	End	E-Value	Type
transmembrane domain	15	34	N/A	INTRINSIC
TNFR	48	82	9.53e-2	SMART
TNFR	85	124	3.31e-10	SMART
TNFR	126	165	6.48e-4	SMART
low complexity region	166	177	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000146692
AA Change: K61*

SMART Domains

Protein: ENSMUSP00000119297
Gene: ENSMUSG00000010751
AA Change: K61*

Domain	Start	End	E-Value	Type
transmembrane domain	15	34	N/A	INTRINSIC
TNFR	48	82	9.53e-2	SMART
TNFR	85	124	3.31e-10	SMART
TNFR	126	165	6.48e-4	SMART
low complexity region	166	177	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207189

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aaas	T	A	15: 102,247,627 (GRCm39)	M415L	probably benign	Het
Akap6	T	C	12: 53,057,389 (GRCm39)	S952P	probably benign	Het
Aldh3a1	A	G	11: 61,107,147 (GRCm39)	R284G	probably damaging	Het
Aldh3b1	G	T	19: 3,964,061 (GRCm39)	H414N	probably damaging	Het
Chd5	G	A	4: 152,440,564 (GRCm39)	M141I	possibly damaging	Het
Cntn2	C	T	1: 132,453,654 (GRCm39)	A340T	possibly damaging	Het
Daw1	T	A	1: 83,187,055 (GRCm39)	C288*	probably null	Het
Dcn	A	G	10: 97,319,319 (GRCm39)	E32G	probably damaging	Het
Dock5	C	T	14: 68,065,888 (GRCm39)	V372M	probably benign	Het
Etf1	T	C	18: 35,064,670 (GRCm39)	E13G	probably damaging	Het
Filip1l	A	G	16: 57,392,469 (GRCm39)	E781G	probably benign	Het
Gucy1a2	A	G	9: 3,635,113 (GRCm39)	I386V	probably damaging	Het
Gvin-ps5	T	A	7: 105,928,876 (GRCm39)		noncoding transcript	Het
Hoxb5	T	A	11: 96,195,969 (GRCm39)		probably benign	Het
Iqch	T	A	9: 63,329,110 (GRCm39)		probably benign	Het
Itgal	C	T	7: 126,909,416 (GRCm39)	P423S	probably damaging	Het
Kti12	T	G	4: 108,705,359 (GRCm39)	L91R	probably damaging	Het
Lgals3	T	C	14: 47,623,058 (GRCm39)	M239T	probably benign	Het
Lrrc8a	T	C	2: 30,146,311 (GRCm39)	M375T	possibly damaging	Het
Ly75	T	C	2: 60,152,244 (GRCm39)	E1103G	probably benign	Het
Lyst	A	T	13: 13,887,339 (GRCm39)	E3056V	probably damaging	Het
Map3k7	T	C	4: 31,981,452 (GRCm39)		probably benign	Het
Ncor1	G	A	11: 62,264,040 (GRCm39)	T180I	probably benign	Het
Nectin4	T	C	1: 171,212,341 (GRCm39)	V313A	probably benign	Het
Nol4l	A	G	2: 153,278,213 (GRCm39)	S8P	possibly damaging	Het
Npas2	T	A	1: 39,384,527 (GRCm39)	S607T	probably benign	Het
Nup155	T	A	15: 8,138,955 (GRCm39)	M9K	probably benign	Het
Nwd1	T	C	8: 73,394,003 (GRCm39)	L422P	probably damaging	Het
Or14j3	T	A	17: 37,901,110 (GRCm39)	I45F	probably damaging	Het
Papola	G	T	12: 105,775,818 (GRCm39)	G245C	probably damaging	Het
Pcdhb6	T	C	18: 37,467,747 (GRCm39)	S223P	probably damaging	Het
Pdcd4	T	C	19: 53,915,638 (GRCm39)		probably null	Het
Pigg	T	C	5: 108,460,869 (GRCm39)	F27L	probably damaging	Het
Prpf40a	A	T	2: 53,036,165 (GRCm39)	M588K	probably damaging	Het
Psme4	A	G	11: 30,770,944 (GRCm39)	N764S	probably benign	Het
Ptar1	A	C	19: 23,683,076 (GRCm39)	E110A	possibly damaging	Het
Rbm12	A	T	2: 155,937,818 (GRCm39)		probably benign	Het
Rfx7	A	G	9: 72,524,576 (GRCm39)	T589A	probably benign	Het
Rpl21-ps4	G	T	14: 11,227,831 (GRCm38)		noncoding transcript	Het
Rpp38	T	C	2: 3,330,198 (GRCm39)	T235A	probably benign	Het
Sbno2	A	T	10: 79,903,236 (GRCm39)		probably null	Het
Scn3a	A	T	2: 65,354,510 (GRCm39)	C337*	probably null	Het
Sec61a2	T	C	2: 5,879,073 (GRCm39)	T312A	probably benign	Het
Snrpg	C	A	6: 86,353,550 (GRCm39)	D43E	probably damaging	Het
Stag1	A	T	9: 100,639,822 (GRCm39)	Q126L	probably null	Het
Taar6	A	G	10: 23,861,081 (GRCm39)	V155A	probably benign	Het
Tet1	G	A	10: 62,715,388 (GRCm39)	H136Y	possibly damaging	Het
Tet1	C	A	10: 62,674,866 (GRCm39)	S1070I	probably damaging	Het
Tfcp2	T	C	15: 100,411,991 (GRCm39)	T327A	possibly damaging	Het
Tnfrsf13c	C	T	15: 82,107,364 (GRCm39)	V144M	probably damaging	Het
Trhr	T	C	15: 44,061,074 (GRCm39)	V198A	probably benign	Het
Trp53inp2	A	G	2: 155,228,569 (GRCm39)	R175G	probably damaging	Het
Try10	G	A	6: 41,332,421 (GRCm39)	G26R	probably damaging	Het
Vmn1r205	A	G	13: 22,776,370 (GRCm39)	V244A	probably damaging	Het
Wrnip1	T	A	13: 32,990,857 (GRCm39)	L372H	probably damaging	Het
Zfp280d	T	A	9: 72,215,261 (GRCm39)	L149Q	probably damaging	Het
Zfp445	A	G	9: 122,690,940 (GRCm39)	V85A	probably damaging	Het

Other mutations in Tnfrsf22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01323:Tnfrsf22	APN	7	143,197,111 (GRCm39)	missense	probably damaging	1.00
IGL01959:Tnfrsf22	APN	7	143,197,012 (GRCm39)	critical splice donor site	probably null
IGL02395:Tnfrsf22	APN	7	143,197,053 (GRCm39)	missense	probably damaging	1.00
IGL03054:Tnfrsf22	UTSW	7	143,194,532 (GRCm39)	missense	probably damaging	1.00
R1987:Tnfrsf22	UTSW	7	143,192,126 (GRCm39)	unclassified	probably benign
R2228:Tnfrsf22	UTSW	7	143,198,513 (GRCm39)	splice site	probably null
R2229:Tnfrsf22	UTSW	7	143,198,513 (GRCm39)	splice site	probably null
R4562:Tnfrsf22	UTSW	7	143,203,313 (GRCm39)	missense	unknown
R4829:Tnfrsf22	UTSW	7	143,197,067 (GRCm39)	missense	possibly damaging	0.91
R6486:Tnfrsf22	UTSW	7	143,194,493 (GRCm39)	missense	possibly damaging	0.93
R6903:Tnfrsf22	UTSW	7	143,193,641 (GRCm39)	unclassified	probably benign
R7146:Tnfrsf22	UTSW	7	143,194,556 (GRCm39)	missense	probably damaging	1.00
R7406:Tnfrsf22	UTSW	7	143,194,564 (GRCm39)	missense	probably damaging	1.00
R8108:Tnfrsf22	UTSW	7	143,192,110 (GRCm39)	missense	unknown
R8969:Tnfrsf22	UTSW	7	143,192,173 (GRCm39)	missense	unknown
R9613:Tnfrsf22	UTSW	7	143,198,583 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16