Incidental Mutation 'IGL02611:St18'
ID 300482
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol St18
Ensembl Gene ENSMUSG00000033740
Gene Name suppression of tumorigenicity 18
Synonyms Nzf3, Myt3
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02611
Quality Score
Status
Chromosome 1
Chromosomal Location 6487231-6860940 bp(+) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 6768890 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000131417 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043578] [ENSMUST00000131467] [ENSMUST00000131494] [ENSMUST00000139756] [ENSMUST00000139838] [ENSMUST00000140079] [ENSMUST00000150761] [ENSMUST00000151281] [ENSMUST00000163727]
AlphaFold Q80TY4
Predicted Effect probably benign
Transcript: ENSMUST00000043578
SMART Domains Protein: ENSMUSP00000042056
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Pfam:zf-C2HC 365 392 7.8e-15 PFAM
Pfam:zf-C2HC 409 437 4.2e-17 PFAM
Pfam:MYT1 476 713 1.3e-75 PFAM
Pfam:zf-C2HC 721 749 4e-19 PFAM
Pfam:zf-C2HC 765 793 1.7e-19 PFAM
Pfam:zf-C2HC 813 841 1.1e-17 PFAM
Pfam:zf-C2HC 866 893 9.1e-15 PFAM
coiled coil region 918 987 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000131467
Predicted Effect probably benign
Transcript: ENSMUST00000131494
SMART Domains Protein: ENSMUSP00000117789
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Pfam:zf-C2HC 363 393 2.6e-17 PFAM
Pfam:zf-C2HC 407 437 1e-18 PFAM
Pfam:MYT1 476 714 1.5e-116 PFAM
Pfam:zf-C2HC 719 749 1e-19 PFAM
Pfam:zf-C2HC 763 793 1.3e-20 PFAM
Pfam:zf-C2HC 811 841 8.9e-19 PFAM
Pfam:zf-C2HC 864 894 1.3e-16 PFAM
coiled coil region 918 987 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000139756
Predicted Effect probably benign
Transcript: ENSMUST00000139838
SMART Domains Protein: ENSMUSP00000118129
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000140079
SMART Domains Protein: ENSMUSP00000118322
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Pfam:zf-C2HC 363 393 2.6e-17 PFAM
Pfam:zf-C2HC 407 437 1e-18 PFAM
Pfam:MYT1 476 714 1.5e-116 PFAM
Pfam:zf-C2HC 719 749 1e-19 PFAM
Pfam:zf-C2HC 763 793 1.3e-20 PFAM
Pfam:zf-C2HC 811 841 8.9e-19 PFAM
Pfam:zf-C2HC 864 894 1.3e-16 PFAM
coiled coil region 918 987 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000150761
SMART Domains Protein: ENSMUSP00000120298
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Pfam:zf-C2HC 363 393 2.6e-17 PFAM
Pfam:zf-C2HC 407 437 1e-18 PFAM
Pfam:MYT1 476 714 1.5e-116 PFAM
Pfam:zf-C2HC 719 749 1e-19 PFAM
Pfam:zf-C2HC 763 793 1.3e-20 PFAM
Pfam:zf-C2HC 811 841 8.9e-19 PFAM
Pfam:zf-C2HC 864 894 1.3e-16 PFAM
coiled coil region 918 987 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000151281
SMART Domains Protein: ENSMUSP00000122055
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Pfam:zf-C2HC 363 393 2.6e-17 PFAM
Pfam:zf-C2HC 407 437 1e-18 PFAM
Pfam:MYT1 476 714 1.5e-116 PFAM
Pfam:zf-C2HC 719 749 1e-19 PFAM
Pfam:zf-C2HC 763 793 1.3e-20 PFAM
Pfam:zf-C2HC 811 841 8.9e-19 PFAM
Pfam:zf-C2HC 864 894 1.3e-16 PFAM
coiled coil region 918 987 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000163727
SMART Domains Protein: ENSMUSP00000131417
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Pfam:zf-C2HC 365 392 7.8e-15 PFAM
Pfam:zf-C2HC 409 437 4.2e-17 PFAM
Pfam:MYT1 476 713 1.3e-75 PFAM
Pfam:zf-C2HC 721 749 4e-19 PFAM
Pfam:zf-C2HC 765 793 1.7e-19 PFAM
Pfam:zf-C2HC 813 841 1.1e-17 PFAM
Pfam:zf-C2HC 866 893 9.1e-15 PFAM
coiled coil region 918 987 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Chac1 T A 2: 119,353,453 (GRCm38) Y179N probably damaging Het
Cyp2c37 T G 19: 39,993,865 (GRCm38) F103L probably benign Het
Dmp1 A T 5: 104,212,514 (GRCm38) D352V probably damaging Het
Dpp8 T C 9: 65,055,793 (GRCm38) I443T probably benign Het
Furin G A 7: 80,391,778 (GRCm38) A544V probably benign Het
Galntl6 A G 8: 57,958,416 (GRCm38) M260T probably damaging Het
Gm17654 G A 14: 43,579,005 (GRCm38) T47I possibly damaging Het
Hadha A G 5: 30,128,943 (GRCm38) probably benign Het
Itfg2 T A 6: 128,424,725 (GRCm38) N30I probably damaging Het
Kntc1 T A 5: 123,812,065 (GRCm38) L1977H probably damaging Het
Lats1 T C 10: 7,705,787 (GRCm38) F779L possibly damaging Het
Ltbp4 T C 7: 27,310,655 (GRCm38) Y1160C probably damaging Het
Mcm7 C A 5: 138,167,439 (GRCm38) S401I probably damaging Het
Olfr659 A T 7: 104,671,407 (GRCm38) D235V possibly damaging Het
Olfr694 G T 7: 106,688,789 (GRCm38) T314K probably benign Het
Pcdh8 C T 14: 79,767,667 (GRCm38) V876I probably benign Het
Pfpl T C 19: 12,430,283 (GRCm38) S633P probably benign Het
Psg29 G A 7: 17,208,791 (GRCm38) R239Q probably benign Het
Syt2 G A 1: 134,741,882 (GRCm38) C87Y possibly damaging Het
Unc79 A G 12: 103,165,708 (GRCm38) T2300A probably damaging Het
Other mutations in St18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:St18 APN 1 6,802,572 (GRCm38) missense probably benign 0.07
IGL00840:St18 APN 1 6,833,594 (GRCm38) missense probably damaging 1.00
IGL01016:St18 APN 1 6,844,323 (GRCm38) missense probably damaging 0.98
IGL01116:St18 APN 1 6,802,632 (GRCm38) missense probably damaging 0.96
IGL01719:St18 APN 1 6,845,796 (GRCm38) splice site probably benign
IGL01885:St18 APN 1 6,844,372 (GRCm38) critical splice donor site probably null
IGL02486:St18 APN 1 6,820,083 (GRCm38) missense probably damaging 1.00
IGL02742:St18 APN 1 6,802,316 (GRCm38) splice site probably benign
IGL02953:St18 APN 1 6,844,113 (GRCm38) splice site probably benign
IGL02999:St18 APN 1 6,817,605 (GRCm38) missense probably benign 0.01
IGL03092:St18 APN 1 6,768,894 (GRCm38) splice site probably benign
Smallish UTSW 1 6,855,473 (GRCm38) critical splice donor site probably null
IGL03055:St18 UTSW 1 6,802,735 (GRCm38) missense probably damaging 0.99
R0089:St18 UTSW 1 6,848,948 (GRCm38) missense probably benign 0.02
R0257:St18 UTSW 1 6,819,962 (GRCm38) missense probably benign 0.04
R0383:St18 UTSW 1 6,803,024 (GRCm38) missense probably damaging 1.00
R0588:St18 UTSW 1 6,817,738 (GRCm38) missense probably damaging 0.99
R0989:St18 UTSW 1 6,827,881 (GRCm38) missense probably benign 0.04
R1068:St18 UTSW 1 6,795,562 (GRCm38) missense probably benign 0.01
R1311:St18 UTSW 1 6,845,644 (GRCm38) missense probably damaging 1.00
R1530:St18 UTSW 1 6,845,569 (GRCm38) critical splice acceptor site probably null
R1723:St18 UTSW 1 6,810,685 (GRCm38) splice site probably benign
R1926:St18 UTSW 1 6,802,689 (GRCm38) missense probably benign 0.00
R1927:St18 UTSW 1 6,802,712 (GRCm38) missense probably benign 0.00
R2035:St18 UTSW 1 6,802,328 (GRCm38) missense probably benign 0.00
R2091:St18 UTSW 1 6,827,971 (GRCm38) missense probably benign 0.08
R2139:St18 UTSW 1 6,810,615 (GRCm38) missense possibly damaging 0.85
R2261:St18 UTSW 1 6,845,572 (GRCm38) missense probably damaging 0.96
R2300:St18 UTSW 1 6,855,402 (GRCm38) missense probably damaging 1.00
R2322:St18 UTSW 1 6,844,124 (GRCm38) nonsense probably null
R2846:St18 UTSW 1 6,845,587 (GRCm38) missense probably damaging 0.96
R3738:St18 UTSW 1 6,855,473 (GRCm38) critical splice donor site probably null
R3739:St18 UTSW 1 6,855,473 (GRCm38) critical splice donor site probably null
R3772:St18 UTSW 1 6,844,329 (GRCm38) missense probably damaging 1.00
R3805:St18 UTSW 1 6,802,353 (GRCm38) missense probably damaging 1.00
R3953:St18 UTSW 1 6,802,893 (GRCm38) missense probably damaging 0.99
R4034:St18 UTSW 1 6,855,473 (GRCm38) critical splice donor site probably null
R4036:St18 UTSW 1 6,827,786 (GRCm38) missense probably damaging 1.00
R4407:St18 UTSW 1 6,827,837 (GRCm38) missense probably benign 0.29
R4527:St18 UTSW 1 6,855,423 (GRCm38) missense probably damaging 1.00
R4740:St18 UTSW 1 6,817,604 (GRCm38) missense probably benign
R4838:St18 UTSW 1 6,802,905 (GRCm38) missense probably benign 0.01
R5182:St18 UTSW 1 6,817,653 (GRCm38) missense probably benign 0.03
R5186:St18 UTSW 1 6,802,317 (GRCm38) splice site probably null
R5354:St18 UTSW 1 6,844,171 (GRCm38) missense probably damaging 1.00
R5423:St18 UTSW 1 6,802,616 (GRCm38) missense possibly damaging 0.91
R5724:St18 UTSW 1 6,770,950 (GRCm38) missense probably benign 0.13
R6182:St18 UTSW 1 6,844,118 (GRCm38) splice site probably null
R6491:St18 UTSW 1 6,827,985 (GRCm38) nonsense probably null
R6503:St18 UTSW 1 6,795,397 (GRCm38) missense probably damaging 1.00
R7037:St18 UTSW 1 6,803,036 (GRCm38) missense possibly damaging 0.65
R7098:St18 UTSW 1 6,827,842 (GRCm38) missense probably damaging 1.00
R7132:St18 UTSW 1 6,859,127 (GRCm38) missense
R7144:St18 UTSW 1 6,833,594 (GRCm38) missense probably damaging 1.00
R7150:St18 UTSW 1 6,803,019 (GRCm38) missense probably damaging 1.00
R7334:St18 UTSW 1 6,802,559 (GRCm38) missense probably benign 0.00
R7502:St18 UTSW 1 6,827,970 (GRCm38) missense probably benign 0.09
R7729:St18 UTSW 1 6,802,537 (GRCm38) missense probably benign 0.00
R7848:St18 UTSW 1 6,857,445 (GRCm38) critical splice donor site probably null
R8088:St18 UTSW 1 6,828,005 (GRCm38) missense probably benign 0.00
R8299:St18 UTSW 1 6,802,992 (GRCm38) missense probably benign 0.01
R8338:St18 UTSW 1 6,809,292 (GRCm38) missense probably damaging 1.00
R8690:St18 UTSW 1 6,802,564 (GRCm38) missense probably benign
R8753:St18 UTSW 1 6,845,791 (GRCm38) missense probably damaging 1.00
R8808:St18 UTSW 1 6,810,602 (GRCm38) missense probably damaging 1.00
R8880:St18 UTSW 1 6,795,395 (GRCm38) nonsense probably null
R9055:St18 UTSW 1 6,802,982 (GRCm38) nonsense probably null
R9292:St18 UTSW 1 6,827,882 (GRCm38) missense probably benign 0.32
R9322:St18 UTSW 1 6,795,523 (GRCm38) missense probably benign 0.00
R9530:St18 UTSW 1 6,802,773 (GRCm38) missense probably benign 0.00
R9603:St18 UTSW 1 6,845,587 (GRCm38) missense probably damaging 1.00
R9611:St18 UTSW 1 6,802,923 (GRCm38) missense probably benign 0.00
R9639:St18 UTSW 1 6,859,022 (GRCm38) missense
R9644:St18 UTSW 1 6,859,052 (GRCm38) missense
R9740:St18 UTSW 1 6,803,063 (GRCm38) nonsense probably null
R9750:St18 UTSW 1 6,802,992 (GRCm38) missense probably benign 0.01
Posted On 2015-04-16