Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02612:Or8b37'

300484

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or8b37

Ensembl Gene

ENSMUSG00000095893

Gene Name

olfactory receptor family 8 subfamily B member 37

Synonyms

GA_x6K02T2PVTD-31726544-31727473, MOR162-9P, MOR162-11P, Olfr1550-ps1, MOR162-13, Olfr884, MOR162-11P

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.078) question?

Stock #

IGL02612

Quality Score

Status

Chromosome

Chromosomal Location

37957851-37961433 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 37958662 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 48 (L48Q)

Ref Sequence

ENSEMBL: ENSMUSP00000138035 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077732] [ENSMUST00000181088]

AlphaFold

Q7TRE1

Predicted Effect

probably damaging
Transcript: ENSMUST00000077732
AA Change: L48Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000076912
Gene: ENSMUSG00000095893
AA Change: L48Q

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	306	8e-51	PFAM
Pfam:7TM_GPCR_Srsx	35	300	1.5e-6	PFAM
Pfam:7tm_1	41	288	5.1e-24	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000181088
AA Change: L48Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000138035
Gene: ENSMUSG00000095893
AA Change: L48Q

Domain	Start	End	E-Value	Type
low complexity region	14	33	N/A	INTRINSIC
Pfam:7TM_GPCR_Srsx	35	300	1.5e-6	PFAM
Pfam:7tm_1	41	288	4.6e-30	PFAM
Pfam:7tm_4	138	281	3.9e-45	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	A	T	6: 121,654,971 (GRCm39)	M1432L	probably benign	Het
Alg11	A	G	8: 22,551,999 (GRCm39)	R48G	probably benign	Het
Armc8	T	C	9: 99,409,122 (GRCm39)		probably benign	Het
Bmp4	T	A	14: 46,621,938 (GRCm39)	D202V	probably damaging	Het
Car12	T	G	9: 66,669,706 (GRCm39)	L300R	probably damaging	Het
Cdc37l1	T	A	19: 28,993,502 (GRCm39)	*336R	probably null	Het
Cep89	A	G	7: 35,124,080 (GRCm39)		probably null	Het
Ces3b	T	A	8: 105,811,901 (GRCm39)	D103E	possibly damaging	Het
Chd5	A	G	4: 152,445,033 (GRCm39)	D338G	probably damaging	Het
Crot	A	G	5: 9,019,945 (GRCm39)	C466R	probably damaging	Het
Dach2	T	C	X: 112,660,101 (GRCm39)	M194T	probably benign	Het
Dmrtc1b	A	G	X: 101,756,873 (GRCm39)	D100G	probably benign	Het
Epm2a	G	A	10: 11,332,980 (GRCm39)	R271H	probably damaging	Het
Fem1c	G	T	18: 46,638,781 (GRCm39)	T407K	probably benign	Het
Fer1l4	T	C	2: 155,889,848 (GRCm39)	Y273C	probably damaging	Het
Foxc2	C	A	8: 121,844,576 (GRCm39)	A408E	probably benign	Het
Gbp10	A	T	5: 105,366,368 (GRCm39)	M512K	possibly damaging	Het
Gm5134	T	C	10: 75,828,323 (GRCm39)	L301P	probably damaging	Het
Grk3	A	T	5: 113,117,100 (GRCm39)	D100E	probably benign	Het
Gsdma3	T	A	11: 98,526,707 (GRCm39)	D322E	probably damaging	Het
Gucy1a2	C	A	9: 3,894,556 (GRCm39)	L680I	possibly damaging	Het
Ighv7-2	T	C	12: 113,875,766 (GRCm39)	Y79C	probably damaging	Het
Igkv4-50	T	C	6: 69,678,024 (GRCm39)	T27A	probably benign	Het
Ints2	T	C	11: 86,106,404 (GRCm39)	D1002G	probably damaging	Het
Map4k5	T	A	12: 69,896,358 (GRCm39)	I169F	possibly damaging	Het
Mink1	T	C	11: 70,488,052 (GRCm39)	V39A	probably damaging	Het
Mms22l	T	A	4: 24,508,482 (GRCm39)	H301Q	probably benign	Het
Myh4	C	T	11: 67,147,305 (GRCm39)	T1650I	probably benign	Het
Or52n4	A	T	7: 104,293,870 (GRCm39)	D234E	probably benign	Het
Or8b44	T	C	9: 38,410,769 (GRCm39)	M268T	probably benign	Het
Pate10	T	C	9: 35,653,460 (GRCm39)	I88T	possibly damaging	Het
Pbxip1	C	T	3: 89,350,988 (GRCm39)	T117M	probably damaging	Het
Pgghg	C	T	7: 140,526,251 (GRCm39)	T572M	probably damaging	Het
Phactr2	G	A	10: 13,121,167 (GRCm39)	T511I	probably damaging	Het
Pip5k1a	T	C	3: 94,974,724 (GRCm39)	I385V	probably benign	Het
Pwp2	A	G	10: 78,018,828 (GRCm39)	C60R	probably damaging	Het
Rgs11	G	A	17: 26,426,605 (GRCm39)	V279I	probably benign	Het
Rttn	G	T	18: 88,991,750 (GRCm39)	D110Y	probably damaging	Het
Setbp1	G	T	18: 78,798,925 (GRCm39)	H1418Q	probably damaging	Het
Sf3b3	T	C	8: 111,569,608 (GRCm39)	I37V	probably benign	Het
Slc27a6	A	T	18: 58,689,977 (GRCm39)	I148F	probably benign	Het
Slmap	A	G	14: 26,180,621 (GRCm39)		probably benign	Het
Speer4a3	A	C	5: 26,156,614 (GRCm39)	Y122D	probably benign	Het
Stil	A	G	4: 114,880,893 (GRCm39)	Q479R	possibly damaging	Het
Svop	A	G	5: 114,166,321 (GRCm39)	*549Q	probably null	Het
Tnks	C	T	8: 35,316,453 (GRCm39)	V889I	possibly damaging	Het
Tnrc6c	T	A	11: 117,633,826 (GRCm39)	V1308E	possibly damaging	Het
Vmn1r208	C	A	13: 22,956,993 (GRCm39)	C168F	probably damaging	Het
Vmn2r117	A	T	17: 23,678,758 (GRCm39)	M822K	possibly damaging	Het
Vwa8	A	G	14: 79,420,552 (GRCm39)	N1751S	probably benign	Het
Vwde	A	T	6: 13,187,148 (GRCm39)	F780I	probably damaging	Het
Washc2	T	C	6: 116,197,577 (GRCm39)	I184T	possibly damaging	Het
Wdr26	A	T	1: 181,005,361 (GRCm39)		probably benign	Het
Zfp608	G	A	18: 55,031,273 (GRCm39)	T889M	probably damaging	Het
Zfp955a	G	T	17: 33,463,039 (GRCm39)	Q31K	probably damaging	Het
Zpbp2	T	C	11: 98,446,343 (GRCm39)	L145S	probably benign	Het

Other mutations in Or8b37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00870:Or8b37	APN	9	37,959,036 (GRCm39)	missense	probably damaging	1.00
IGL02802:Or8b37	UTSW	9	37,959,345 (GRCm39)	missense	probably damaging	0.99
R0015:Or8b37	UTSW	9	37,958,963 (GRCm39)	nonsense	probably null
R0142:Or8b37	UTSW	9	37,959,406 (GRCm39)	missense	probably benign	0.37
R0559:Or8b37	UTSW	9	37,959,123 (GRCm39)	missense	probably benign	0.16
R0561:Or8b37	UTSW	9	37,959,123 (GRCm39)	missense	probably benign	0.16
R0715:Or8b37	UTSW	9	37,959,123 (GRCm39)	missense	probably benign	0.16
R0723:Or8b37	UTSW	9	37,959,123 (GRCm39)	missense	probably benign	0.16
R0729:Or8b37	UTSW	9	37,959,123 (GRCm39)	missense	probably benign	0.16
R1350:Or8b37	UTSW	9	37,959,111 (GRCm39)	missense	probably benign	0.02
R1869:Or8b37	UTSW	9	37,959,498 (GRCm39)	splice site	probably null
R3917:Or8b37	UTSW	9	37,958,841 (GRCm39)	missense	probably damaging	1.00
R4131:Or8b37	UTSW	9	37,959,170 (GRCm39)	nonsense	probably null
R4764:Or8b37	UTSW	9	37,959,436 (GRCm39)	missense	probably benign
R5857:Or8b37	UTSW	9	37,959,049 (GRCm39)	missense	probably benign	0.18
R5976:Or8b37	UTSW	9	37,958,997 (GRCm39)	missense	possibly damaging	0.80
R6329:Or8b37	UTSW	9	37,959,121 (GRCm39)	missense	probably benign	0.02
R7344:Or8b37	UTSW	9	37,959,253 (GRCm39)	missense	probably benign
R8289:Or8b37	UTSW	9	37,959,000 (GRCm39)	missense	probably benign	0.02
R8485:Or8b37	UTSW	9	37,959,253 (GRCm39)	missense	probably benign	0.00
R8973:Or8b37	UTSW	9	37,958,839 (GRCm39)	missense	possibly damaging	0.95
R9026:Or8b37	UTSW	9	37,958,885 (GRCm39)	nonsense	probably null
R9378:Or8b37	UTSW	9	37,958,775 (GRCm39)	missense	possibly damaging	0.67
R9395:Or8b37	UTSW	9	37,959,136 (GRCm39)	missense	probably damaging	0.99
R9655:Or8b37	UTSW	9	37,959,387 (GRCm39)	missense	probably benign	0.00
R9731:Or8b37	UTSW	9	37,958,892 (GRCm39)	missense	probably damaging	1.00
RF009:Or8b37	UTSW	9	37,959,043 (GRCm39)	missense	probably damaging	1.00
X0052:Or8b37	UTSW	9	37,958,995 (GRCm39)	missense	possibly damaging	0.53
Z1177:Or8b37	UTSW	9	37,959,111 (GRCm39)	missense	possibly damaging	0.95

Posted On

2015-04-16