Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02612:Vmn2r117'

300488

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r117

Ensembl Gene

ENSMUSG00000091407

Gene Name

vomeronasal 2, receptor 117

Synonyms

EG619788

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

IGL02612

Quality Score

Status

Chromosome

Chromosomal Location

23459675-23479597 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 23459784 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 822 (M822K)

Ref Sequence

ENSEMBL: ENSMUSP00000126885 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171996]

AlphaFold

K7N6V1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000171996
AA Change: M822K

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000126885
Gene: ENSMUSG00000091407
AA Change: M822K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.6e-28	PFAM
Pfam:NCD3G	512	565	5e-20	PFAM
Pfam:7tm_3	595	833	8.2e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	A	T	6: 121,678,012	M1432L	probably benign	Het
Alg11	A	G	8: 22,061,983	R48G	probably benign	Het
Armc8	T	C	9: 99,527,069		probably benign	Het
Bmp4	T	A	14: 46,384,481	D202V	probably damaging	Het
Car12	T	G	9: 66,762,424	L300R	probably damaging	Het
Cdc37l1	T	A	19: 29,016,102	*336R	probably null	Het
Cep89	A	G	7: 35,424,655		probably null	Het
Ces3b	T	A	8: 105,085,269	D103E	possibly damaging	Het
Chd5	A	G	4: 152,360,576	D338G	probably damaging	Het
Crot	A	G	5: 8,969,945	C466R	probably damaging	Het
Dach2	T	C	X: 113,750,404	M194T	probably benign	Het
Dmrtc1b	A	G	X: 102,713,267	D100G	probably benign	Het
Epm2a	G	A	10: 11,457,236	R271H	probably damaging	Het
Fem1c	G	T	18: 46,505,714	T407K	probably benign	Het
Fer1l4	T	C	2: 156,047,928	Y273C	probably damaging	Het
Foxc2	C	A	8: 121,117,837	A408E	probably benign	Het
Gbp10	A	T	5: 105,218,502	M512K	possibly damaging	Het
Gm17677	T	C	9: 35,742,164	I88T	possibly damaging	Het
Gm21671	A	C	5: 25,951,616	Y122D	probably benign	Het
Gm5134	T	C	10: 75,992,489	L301P	probably damaging	Het
Grk3	A	T	5: 112,969,234	D100E	probably benign	Het
Gsdma3	T	A	11: 98,635,881	D322E	probably damaging	Het
Gucy1a2	C	A	9: 3,894,556	L680I	possibly damaging	Het
Ighv7-2	T	C	12: 113,912,146	Y79C	probably damaging	Het
Igkv4-50	T	C	6: 69,701,040	T27A	probably benign	Het
Ints2	T	C	11: 86,215,578	D1002G	probably damaging	Het
Map4k5	T	A	12: 69,849,584	I169F	possibly damaging	Het
Mink1	T	C	11: 70,597,226	V39A	probably damaging	Het
Mms22l	T	A	4: 24,508,482	H301Q	probably benign	Het
Myh4	C	T	11: 67,256,479	T1650I	probably benign	Het
Olfr658	A	T	7: 104,644,663	D234E	probably benign	Het
Olfr884	T	A	9: 38,047,366	L48Q	probably damaging	Het
Olfr907	T	C	9: 38,499,473	M268T	probably benign	Het
Pbxip1	C	T	3: 89,443,681	T117M	probably damaging	Het
Pgghg	C	T	7: 140,946,338	T572M	probably damaging	Het
Phactr2	G	A	10: 13,245,423	T511I	probably damaging	Het
Pip5k1a	T	C	3: 95,067,413	I385V	probably benign	Het
Pwp2	A	G	10: 78,182,994	C60R	probably damaging	Het
Rgs11	G	A	17: 26,207,631	V279I	probably benign	Het
Rttn	G	T	18: 88,973,626	D110Y	probably damaging	Het
Setbp1	G	T	18: 78,755,710	H1418Q	probably damaging	Het
Sf3b3	T	C	8: 110,842,976	I37V	probably benign	Het
Slc27a6	A	T	18: 58,556,905	I148F	probably benign	Het
Slmap	A	G	14: 26,459,466		probably benign	Het
Stil	A	G	4: 115,023,696	Q479R	possibly damaging	Het
Svop	A	G	5: 114,028,260	*549Q	probably null	Het
Tnks	C	T	8: 34,849,299	V889I	possibly damaging	Het
Tnrc6c	T	A	11: 117,743,000	V1308E	possibly damaging	Het
Vmn1r208	C	A	13: 22,772,823	C168F	probably damaging	Het
Vwa8	A	G	14: 79,183,112	N1751S	probably benign	Het
Vwde	A	T	6: 13,187,149	F780I	probably damaging	Het
Washc2	T	C	6: 116,220,616	I184T	possibly damaging	Het
Wdr26	A	T	1: 181,177,796		probably benign	Het
Zfp608	G	A	18: 54,898,201	T889M	probably damaging	Het
Zfp955a	G	T	17: 33,244,065	Q31K	probably damaging	Het
Zpbp2	T	C	11: 98,555,517	L145S	probably benign	Het

Other mutations in Vmn2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r117	APN	17	23477840	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23475429	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23479546	missense	probably benign
IGL01078:Vmn2r117	APN	17	23477804	missense	probably damaging	1.00
IGL01139:Vmn2r117	APN	17	23477804	missense	probably damaging	1.00
IGL01374:Vmn2r117	APN	17	23478382	missense	possibly damaging	0.46
IGL01779:Vmn2r117	APN	17	23477241	missense	probably benign	0.00
IGL02283:Vmn2r117	APN	17	23475382	missense	probably damaging	0.99
IGL02527:Vmn2r117	APN	17	23477225	missense	possibly damaging	0.65
IGL02887:Vmn2r117	APN	17	23475578	splice site	probably benign
IGL03167:Vmn2r117	APN	17	23477707	missense	probably damaging	1.00
R0315:Vmn2r117	UTSW	17	23460165	missense	probably benign	0.11
R0610:Vmn2r117	UTSW	17	23475514	missense	probably benign	0.00
R0747:Vmn2r117	UTSW	17	23475503	nonsense	probably null
R1411:Vmn2r117	UTSW	17	23460553	missense	probably damaging	1.00
R1471:Vmn2r117	UTSW	17	23478473	missense	probably benign	0.00
R1853:Vmn2r117	UTSW	17	23477455	missense	probably damaging	0.99
R1925:Vmn2r117	UTSW	17	23478389	missense	probably benign	0.00
R1940:Vmn2r117	UTSW	17	23477480	missense	probably damaging	1.00
R2005:Vmn2r117	UTSW	17	23477644	missense	probably damaging	1.00
R2082:Vmn2r117	UTSW	17	23460256	missense	possibly damaging	0.55
R2698:Vmn2r117	UTSW	17	23459911	missense	probably damaging	0.98
R2972:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R2973:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R2974:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R3160:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3161:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3162:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3847:Vmn2r117	UTSW	17	23460415	missense	probably damaging	0.97
R3848:Vmn2r117	UTSW	17	23460415	missense	probably damaging	0.97
R4082:Vmn2r117	UTSW	17	23460106	missense	probably benign	0.00
R4320:Vmn2r117	UTSW	17	23479513	frame shift	probably null
R4560:Vmn2r117	UTSW	17	23459877	missense	probably damaging	1.00
R4658:Vmn2r117	UTSW	17	23478416	missense	probably benign	0.01
R4881:Vmn2r117	UTSW	17	23477885	missense	probably damaging	1.00
R4908:Vmn2r117	UTSW	17	23459838	missense	probably damaging	1.00
R4910:Vmn2r117	UTSW	17	23479513	frame shift	probably null
R5078:Vmn2r117	UTSW	17	23460148	missense	probably damaging	1.00
R5327:Vmn2r117	UTSW	17	23477874	nonsense	probably null
R5774:Vmn2r117	UTSW	17	23477202	missense	probably damaging	0.98
R6014:Vmn2r117	UTSW	17	23479561	missense	probably damaging	0.97
R6390:Vmn2r117	UTSW	17	23460114	missense	possibly damaging	0.95
R6520:Vmn2r117	UTSW	17	23460219	missense	probably damaging	0.99
R6674:Vmn2r117	UTSW	17	23460049	nonsense	probably null
R6736:Vmn2r117	UTSW	17	23478308	missense	probably damaging	0.99
R6909:Vmn2r117	UTSW	17	23479505	missense	possibly damaging	0.67
R6913:Vmn2r117	UTSW	17	23479563	missense	probably damaging	0.99
R7220:Vmn2r117	UTSW	17	23477203	missense	probably damaging	1.00
R7260:Vmn2r117	UTSW	17	23475385	missense	probably benign	0.06
R7440:Vmn2r117	UTSW	17	23475565	missense	probably benign	0.26
R7443:Vmn2r117	UTSW	17	23460133	missense	probably benign	0.25
R7443:Vmn2r117	UTSW	17	23460345	missense	probably damaging	1.00
R7449:Vmn2r117	UTSW	17	23459895	missense	probably damaging	1.00
R7644:Vmn2r117	UTSW	17	23477291	missense	probably damaging	0.98
R7914:Vmn2r117	UTSW	17	23460126	missense	possibly damaging	0.95
R8001:Vmn2r117	UTSW	17	23479407	missense	possibly damaging	0.89
R8029:Vmn2r117	UTSW	17	23477770	missense	probably benign	0.00
R8340:Vmn2r117	UTSW	17	23460537	missense	probably benign	0.01
R8519:Vmn2r117	UTSW	17	23479468	missense	probably benign
R8723:Vmn2r117	UTSW	17	23477369	missense	probably damaging	1.00
R8914:Vmn2r117	UTSW	17	23460169	missense	probably benign	0.02
R9010:Vmn2r117	UTSW	17	23460471	missense	probably benign	0.10
R9129:Vmn2r117	UTSW	17	23459944	nonsense	probably null
R9244:Vmn2r117	UTSW	17	23477615	missense	probably damaging	0.98
R9464:Vmn2r117	UTSW	17	23477604	missense	probably benign	0.23
R9620:Vmn2r117	UTSW	17	23478476	missense	probably damaging	0.97
V5622:Vmn2r117	UTSW	17	23477840	missense	probably damaging	1.00
V5622:Vmn2r117	UTSW	17	23479505	missense	possibly damaging	0.67
Z1176:Vmn2r117	UTSW	17	23459766	missense	probably benign	0.00

Posted On

2015-04-16