Incidental Mutation 'IGL02615:Ighv1-64'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ighv1-64
Ensembl Gene ENSMUSG00000094088
Gene Nameimmunoglobulin heavy variable 1-64
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.205) question?
Stock #IGL02615
Quality Score
Chromosomal Location115507587-115507977 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 115507687 bp
Amino Acid Change Isoleucine to Threonine at position 70 (I70T)
Ref Sequence ENSEMBL: ENSMUSP00000100316 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103535]
Predicted Effect possibly damaging
Transcript: ENSMUST00000103535
AA Change: I70T

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000100316
Gene: ENSMUSG00000094088
AA Change: I70T

IGv 36 117 2.29e-30 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430033K04Rik G T 5: 138,646,140 E96* probably null Het
Adck5 C T 15: 76,589,167 S72L possibly damaging Het
Afdn A G 17: 13,825,976 H404R probably benign Het
Aph1c A T 9: 66,819,406 V222E possibly damaging Het
Armc8 T C 9: 99,527,069 probably benign Het
Bcl2l13 A T 6: 120,862,867 D42V probably damaging Het
Bhlhe22 C T 3: 18,054,900 T38I possibly damaging Het
Ccdc51 A T 9: 109,089,435 T31S probably benign Het
Ctbp2 A G 7: 132,995,347 I669T probably benign Het
Dennd4c A G 4: 86,821,467 T998A probably benign Het
Dpp4 T C 2: 62,359,328 Y410C probably damaging Het
Gli2 T A 1: 118,844,398 N526Y probably damaging Het
Gm12394 C T 4: 42,793,027 M368I probably benign Het
Mphosph10 A T 7: 64,381,045 probably benign Het
Mrps34 A G 17: 24,895,793 probably null Het
Myo1f A T 17: 33,604,656 I1053L probably benign Het
Nckap5l G A 15: 99,429,382 P142L possibly damaging Het
Platr26 T A 2: 71,730,426 noncoding transcript Het
Rag2 T A 2: 101,629,568 Y74* probably null Het
Rnf213 A T 11: 119,440,789 M2275L probably damaging Het
Rsbn1 T A 3: 103,953,752 L498Q probably damaging Het
Scp2 A G 4: 108,107,631 V62A probably benign Het
Spag17 A G 3: 100,072,085 I1421V probably benign Het
St6galnac4 A G 2: 32,594,204 H138R probably benign Het
Syne2 T A 12: 76,096,994 M1045K probably damaging Het
Tbxas1 C T 6: 39,027,866 T349M probably damaging Het
U2surp T G 9: 95,493,231 D146A probably benign Het
Usp38 T C 8: 80,985,151 M752V probably benign Het
Other mutations in Ighv1-64
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00841:Ighv1-64 APN 12 115507976 start codon destroyed probably null 1.00
IGL02355:Ighv1-64 APN 12 115507616 missense probably benign 0.01
IGL02362:Ighv1-64 APN 12 115507616 missense probably benign 0.01
IGL03085:Ighv1-64 APN 12 115507841 missense possibly damaging 0.79
R4724:Ighv1-64 UTSW 12 115507846 missense probably benign 0.02
R4829:Ighv1-64 UTSW 12 115507726 missense probably benign
R8080:Ighv1-64 UTSW 12 115507843 missense probably benign 0.00
Z1177:Ighv1-64 UTSW 12 115507666 missense probably benign 0.07
Posted On2015-04-16