Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02615:Armc8'

300641

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Armc8

Ensembl Gene

ENSMUSG00000032468

Gene Name

armadillo repeat containing 8

Synonyms

1200015K23Rik, Gid5, HSPC056

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.683) question?

Stock #

IGL02615

Quality Score

Status

Chromosome

Chromosomal Location

99360425-99450952 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 99409122 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000140426 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035043] [ENSMUST00000185524] [ENSMUST00000186049]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000035043

SMART Domains

Protein: ENSMUSP00000035043
Gene: ENSMUSG00000032468

Domain	Start	End	E-Value	Type
ARM	50	92	1.75e0	SMART
ARM	94	134	5.34e0	SMART
ARM	177	217	2.04e1	SMART
ARM	372	413	3.58e1	SMART
Blast:ARM	414	455	7e-17	BLAST
ARM	457	497	3.81e-1	SMART
ARM	500	540	5.43e1	SMART
Blast:ARM	542	585	1e-20	BLAST
Blast:ARM	633	673	1e-16	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000185524

SMART Domains

Protein: ENSMUSP00000139973
Gene: ENSMUSG00000032468

Domain	Start	End	E-Value	Type
ARM	50	92	1.75e0	SMART
ARM	94	134	5.34e0	SMART
Blast:ARM	138	176	1e-5	BLAST
ARM	177	217	2.04e1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000186049

SMART Domains

Protein: ENSMUSP00000140426
Gene: ENSMUSG00000032468

Domain	Start	End	E-Value	Type
ARM	8	50	8.5e-3	SMART
ARM	52	92	2.6e-2	SMART
Blast:ARM	96	134	7e-6	BLAST
ARM	135	175	9.8e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(6) : Targeted, other(2) Gene trapped(4)

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A430033K04Rik	G	T	5: 138,644,402 (GRCm39)	E96*	probably null	Het
Adck5	C	T	15: 76,473,367 (GRCm39)	S72L	possibly damaging	Het
Afdn	A	G	17: 14,046,238 (GRCm39)	H404R	probably benign	Het
Aph1c	A	T	9: 66,726,688 (GRCm39)	V222E	possibly damaging	Het
Bcl2l13	A	T	6: 120,839,828 (GRCm39)	D42V	probably damaging	Het
Bhlhe22	C	T	3: 18,109,064 (GRCm39)	T38I	possibly damaging	Het
Ccdc51	A	T	9: 108,918,503 (GRCm39)	T31S	probably benign	Het
Ctbp2	A	G	7: 132,597,076 (GRCm39)	I669T	probably benign	Het
Dennd4c	A	G	4: 86,739,704 (GRCm39)	T998A	probably benign	Het
Dpp4	T	C	2: 62,189,672 (GRCm39)	Y410C	probably damaging	Het
Gli2	T	A	1: 118,772,128 (GRCm39)	N526Y	probably damaging	Het
Ighv1-64	A	G	12: 115,471,307 (GRCm39)	I70T	possibly damaging	Het
Mphosph10	A	T	7: 64,030,793 (GRCm39)		probably benign	Het
Mrps34	A	G	17: 25,114,767 (GRCm39)		probably null	Het
Myo1f	A	T	17: 33,823,630 (GRCm39)	I1053L	probably benign	Het
Nckap5l	G	A	15: 99,327,263 (GRCm39)	P142L	possibly damaging	Het
Platr26	T	A	2: 71,560,770 (GRCm39)		noncoding transcript	Het
Rag2	T	A	2: 101,459,913 (GRCm39)	Y74*	probably null	Het
Rnf213	A	T	11: 119,331,615 (GRCm39)	M2275L	probably damaging	Het
Rsbn1	T	A	3: 103,861,068 (GRCm39)	L498Q	probably damaging	Het
Scp2	A	G	4: 107,964,828 (GRCm39)	V62A	probably benign	Het
Spag17	A	G	3: 99,979,401 (GRCm39)	I1421V	probably benign	Het
Spata31f1e	C	T	4: 42,793,027 (GRCm39)	M368I	probably benign	Het
St6galnac4	A	G	2: 32,484,216 (GRCm39)	H138R	probably benign	Het
Syne2	T	A	12: 76,143,768 (GRCm39)	M1045K	probably damaging	Het
Tbxas1	C	T	6: 39,004,800 (GRCm39)	T349M	probably damaging	Het
U2surp	T	G	9: 95,375,284 (GRCm39)	D146A	probably benign	Het
Usp38	T	C	8: 81,711,780 (GRCm39)	M752V	probably benign	Het

Other mutations in Armc8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00232:Armc8	APN	9	99,387,787 (GRCm39)	critical splice acceptor site	probably null
IGL00951:Armc8	APN	9	99,387,757 (GRCm39)	missense	probably benign	0.00
IGL01776:Armc8	APN	9	99,408,936 (GRCm39)	splice site	probably benign
IGL02215:Armc8	APN	9	99,366,031 (GRCm39)	missense	possibly damaging	0.92
IGL02244:Armc8	APN	9	99,365,227 (GRCm39)	missense	probably benign	0.10
IGL02610:Armc8	APN	9	99,409,122 (GRCm39)	splice site	probably benign
IGL02612:Armc8	APN	9	99,409,122 (GRCm39)	splice site	probably benign
IGL02619:Armc8	APN	9	99,409,122 (GRCm39)	splice site	probably benign
IGL02621:Armc8	APN	9	99,409,122 (GRCm39)	splice site	probably benign
IGL02622:Armc8	APN	9	99,409,122 (GRCm39)	splice site	probably benign
IGL02623:Armc8	APN	9	99,409,122 (GRCm39)	splice site	probably benign
IGL02624:Armc8	APN	9	99,409,122 (GRCm39)	splice site	probably benign
Scrambler	UTSW	9	99,378,202 (GRCm39)	critical splice donor site	probably null
warthog	UTSW	9	99,402,538 (GRCm39)	missense	probably benign	0.02
D4043:Armc8	UTSW	9	99,366,029 (GRCm39)	missense	probably benign	0.13
R0321:Armc8	UTSW	9	99,415,230 (GRCm39)	missense	probably damaging	0.99
R0498:Armc8	UTSW	9	99,379,345 (GRCm39)	missense	probably damaging	1.00
R0646:Armc8	UTSW	9	99,387,741 (GRCm39)	missense	probably damaging	1.00
R0658:Armc8	UTSW	9	99,418,211 (GRCm39)	splice site	probably benign
R1061:Armc8	UTSW	9	99,419,784 (GRCm39)	missense	probably damaging	1.00
R1406:Armc8	UTSW	9	99,405,301 (GRCm39)	missense	probably benign	0.37
R1406:Armc8	UTSW	9	99,405,301 (GRCm39)	missense	probably benign	0.37
R1429:Armc8	UTSW	9	99,418,260 (GRCm39)	missense	possibly damaging	0.67
R1432:Armc8	UTSW	9	99,405,185 (GRCm39)	splice site	probably benign
R1538:Armc8	UTSW	9	99,387,343 (GRCm39)	missense	probably damaging	0.96
R1606:Armc8	UTSW	9	99,419,782 (GRCm39)	missense	probably damaging	0.98
R1817:Armc8	UTSW	9	99,418,312 (GRCm39)	missense	possibly damaging	0.67
R1866:Armc8	UTSW	9	99,418,333 (GRCm39)	missense	probably benign
R2015:Armc8	UTSW	9	99,365,158 (GRCm39)	nonsense	probably null
R2143:Armc8	UTSW	9	99,387,361 (GRCm39)	missense	probably damaging	0.99
R2251:Armc8	UTSW	9	99,384,653 (GRCm39)	critical splice acceptor site	probably null
R2842:Armc8	UTSW	9	99,387,734 (GRCm39)	missense	probably benign
R3010:Armc8	UTSW	9	99,369,966 (GRCm39)	missense	probably benign	0.06
R3709:Armc8	UTSW	9	99,402,550 (GRCm39)	missense	probably damaging	1.00
R4440:Armc8	UTSW	9	99,366,087 (GRCm39)	missense	probably benign	0.37
R4865:Armc8	UTSW	9	99,408,942 (GRCm39)	critical splice donor site	probably null
R5492:Armc8	UTSW	9	99,409,184 (GRCm39)	nonsense	probably null
R5606:Armc8	UTSW	9	99,418,315 (GRCm39)	missense	probably benign	0.23
R5639:Armc8	UTSW	9	99,378,202 (GRCm39)	critical splice donor site	probably null
R5693:Armc8	UTSW	9	99,378,202 (GRCm39)	critical splice donor site	probably null
R5694:Armc8	UTSW	9	99,378,202 (GRCm39)	critical splice donor site	probably null
R5698:Armc8	UTSW	9	99,417,873 (GRCm39)	missense	probably benign	0.12
R5700:Armc8	UTSW	9	99,378,202 (GRCm39)	critical splice donor site	probably null
R5701:Armc8	UTSW	9	99,378,202 (GRCm39)	critical splice donor site	probably null
R5735:Armc8	UTSW	9	99,379,447 (GRCm39)	critical splice acceptor site	probably null
R6314:Armc8	UTSW	9	99,417,937 (GRCm39)	missense	probably benign	0.28
R7034:Armc8	UTSW	9	99,366,018 (GRCm39)	critical splice donor site	probably null
R7036:Armc8	UTSW	9	99,366,018 (GRCm39)	critical splice donor site	probably null
R7393:Armc8	UTSW	9	99,366,052 (GRCm39)	missense	possibly damaging	0.47
R7395:Armc8	UTSW	9	99,415,185 (GRCm39)	missense	probably damaging	0.99
R7937:Armc8	UTSW	9	99,418,272 (GRCm39)	missense	probably damaging	0.98
R8130:Armc8	UTSW	9	99,433,600 (GRCm39)	missense	probably benign	0.02
R8373:Armc8	UTSW	9	99,409,152 (GRCm39)	missense	probably benign	0.02
R8734:Armc8	UTSW	9	99,402,538 (GRCm39)	missense	probably benign	0.02
R9098:Armc8	UTSW	9	99,387,362 (GRCm39)	nonsense	probably null
R9255:Armc8	UTSW	9	99,379,441 (GRCm39)	missense	possibly damaging	0.95
R9358:Armc8	UTSW	9	99,450,653 (GRCm39)	critical splice donor site	probably null
R9463:Armc8	UTSW	9	99,378,203 (GRCm39)	critical splice donor site	probably null
Z1177:Armc8	UTSW	9	99,379,439 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16