Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02616:Zc3h10'

300651

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zc3h10

Ensembl Gene

ENSMUSG00000039810

Gene Name

zinc finger CCCH type containing 10

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.893) question?

Stock #

IGL02616

Quality Score

Status

Chromosome

Chromosomal Location

128379429-128383877 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 128380751 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 202 (E202G)

Ref Sequence

ENSEMBL: ENSMUSP00000042727 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000040572] [ENSMUST00000133458] [ENSMUST00000152539] [ENSMUST00000176010] [ENSMUST00000176683] [ENSMUST00000176906] [ENSMUST00000177163]

AlphaFold

Q8R205

Predicted Effect

probably benign
Transcript: ENSMUST00000040572
AA Change: E202G

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000042727
Gene: ENSMUSG00000039810
AA Change: E202G

Domain	Start	End	E-Value	Type
ZnF_C3H1	36	62	3.44e-4	SMART
ZnF_C3H1	75	98	7.41e0	SMART
ZnF_C3H1	134	160	5.67e-5	SMART
low complexity region	167	186	N/A	INTRINSIC
SCOP:d1fxkc_	241	272	2e-3	SMART
low complexity region	334	357	N/A	INTRINSIC
low complexity region	378	403	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000133458

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135226

Predicted Effect

probably benign
Transcript: ENSMUST00000152539

Predicted Effect

probably benign
Transcript: ENSMUST00000176010

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176184

Predicted Effect

probably benign
Transcript: ENSMUST00000176683

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176966

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177513

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188089

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219955

Predicted Effect

probably benign
Transcript: ENSMUST00000176906

Predicted Effect

probably benign
Transcript: ENSMUST00000177163

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700003E16Rik	A	G	6: 83,138,644 (GRCm39)	R190G	probably benign	Het
4931406B18Rik	T	C	7: 43,150,437 (GRCm39)		probably null	Het
Adcy4	T	C	14: 56,020,971 (GRCm39)		probably null	Het
Ahnak	C	A	19: 8,982,991 (GRCm39)	P1425Q	probably benign	Het
Arih1	A	G	9: 59,319,759 (GRCm39)	V285A	probably benign	Het
Atp13a1	T	C	8: 70,257,963 (GRCm39)	V906A	probably benign	Het
Atp2a2	A	T	5: 122,599,747 (GRCm39)	I548N	probably benign	Het
C2cd5	A	T	6: 142,980,837 (GRCm39)	S643T	probably benign	Het
Calcoco1	T	C	15: 102,624,285 (GRCm39)	D210G	probably damaging	Het
Cep128	A	G	12: 91,263,032 (GRCm39)	I289T	probably benign	Het
Ces1c	C	T	8: 93,833,243 (GRCm39)	M407I	probably benign	Het
Cntln	T	G	4: 85,033,689 (GRCm39)		probably null	Het
Cypt12	T	A	3: 18,002,892 (GRCm39)	H88Q	possibly damaging	Het
Ddc	T	A	11: 11,830,645 (GRCm39)		probably benign	Het
Dnajb12	T	C	10: 59,728,685 (GRCm39)		probably null	Het
Gata2	A	G	6: 88,182,462 (GRCm39)	T477A	possibly damaging	Het
Gckr	A	G	5: 31,484,419 (GRCm39)	D619G	probably benign	Het
Gm5699	A	T	1: 31,037,432 (GRCm39)		noncoding transcript	Het
Gm8257	T	A	14: 44,892,683 (GRCm39)	S106C	probably damaging	Het
Gpr15	A	C	16: 58,538,567 (GRCm39)	L174R	probably damaging	Het
Hnrnph3	T	A	10: 62,855,264 (GRCm39)	H7L	possibly damaging	Het
Ide	A	T	19: 37,275,455 (GRCm39)	I518N	unknown	Het
Igdcc4	G	A	9: 65,040,360 (GRCm39)	G957D	probably damaging	Het
Igsf10	G	A	3: 59,226,027 (GRCm39)	P2549S	probably benign	Het
Kcnj9	A	G	1: 172,153,531 (GRCm39)	S198P	probably damaging	Het
Lclat1	T	C	17: 73,476,528 (GRCm39)	I45T	probably benign	Het
Met	T	C	6: 17,553,346 (GRCm39)	L1044S	probably damaging	Het
Msh4	T	C	3: 153,563,160 (GRCm39)	T739A	probably benign	Het
Ncam1	T	C	9: 49,419,988 (GRCm39)	E776G	probably benign	Het
Ndufv3	G	A	17: 31,746,643 (GRCm39)	V178M	probably damaging	Het
Nlgn1	T	C	3: 25,488,409 (GRCm39)	Y613C	probably damaging	Het
Nmbr	T	C	10: 14,636,431 (GRCm39)		probably benign	Het
Orc1	T	A	4: 108,452,676 (GRCm39)	W184R	probably benign	Het
Pde6b	T	C	5: 108,579,407 (GRCm39)	S850P	probably benign	Het
Pip5k1c	C	A	10: 81,153,155 (GRCm39)		probably null	Het
Pnpt1	T	C	11: 29,085,505 (GRCm39)		probably benign	Het
Pomt2	T	A	12: 87,171,636 (GRCm39)	H378L	probably damaging	Het
Sh3gl3	C	T	7: 81,934,226 (GRCm39)		probably benign	Het
Thsd7a	A	T	6: 12,408,984 (GRCm39)	N679K	probably damaging	Het
Tns2	T	C	15: 102,019,850 (GRCm39)	M572T	probably benign	Het
Twf2	C	T	9: 106,089,955 (GRCm39)	Q103*	probably null	Het
Uncx	T	C	5: 139,532,523 (GRCm39)	I196T	possibly damaging	Het
Urgcp	A	G	11: 5,667,400 (GRCm39)	S313P	probably damaging	Het
Vmn1r222	A	T	13: 23,416,311 (GRCm39)	C301S	possibly damaging	Het
Vmn2r111	T	A	17: 22,790,031 (GRCm39)	Q325L	possibly damaging	Het
Vps4a	C	T	8: 107,768,909 (GRCm39)	R236W	probably damaging	Het
Wdr19	T	A	5: 65,380,924 (GRCm39)	H344Q	probably damaging	Het
Wiz	A	T	17: 32,578,443 (GRCm39)	D356E	probably damaging	Het

Other mutations in Zc3h10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01681:Zc3h10	APN	10	128,381,109 (GRCm39)	nonsense	probably null
R0316:Zc3h10	UTSW	10	128,380,624 (GRCm39)	missense	probably damaging	1.00
R1502:Zc3h10	UTSW	10	128,380,151 (GRCm39)	missense	probably damaging	0.97
R1705:Zc3h10	UTSW	10	128,380,672 (GRCm39)	nonsense	probably null
R5739:Zc3h10	UTSW	10	128,380,670 (GRCm39)	missense	probably benign
R5943:Zc3h10	UTSW	10	128,381,396 (GRCm39)	unclassified	probably benign
R6931:Zc3h10	UTSW	10	128,380,553 (GRCm39)	missense	probably damaging	1.00
R7939:Zc3h10	UTSW	10	128,380,376 (GRCm39)	missense	probably damaging	0.99
R8876:Zc3h10	UTSW	10	128,380,163 (GRCm39)	missense	probably damaging	0.96
Z1176:Zc3h10	UTSW	10	128,380,818 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16