Incidental Mutation 'IGL02617:Adgrg5'
ID 300695
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adgrg5
Ensembl Gene ENSMUSG00000061577
Gene Name adhesion G protein-coupled receptor G5
Synonyms Gpr114, PGR27, LOC382045
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02617
Quality Score
Status
Chromosome 8
Chromosomal Location 95650322-95669908 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 95660610 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 79 (D79G)
Ref Sequence ENSEMBL: ENSMUSP00000120217 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074570] [ENSMUST00000128308] [ENSMUST00000153448] [ENSMUST00000166802]
AlphaFold Q3V3Z3
Predicted Effect probably benign
Transcript: ENSMUST00000074570
AA Change: D83G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000074155
Gene: ENSMUSG00000061577
AA Change: D83G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 87 95 N/A INTRINSIC
GPS 181 234 4.7e-13 SMART
Pfam:7tm_2 240 494 2.1e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000128308
AA Change: D79G

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000120217
Gene: ENSMUSG00000061577
AA Change: D79G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 83 91 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142991
Predicted Effect probably benign
Transcript: ENSMUST00000153448
SMART Domains Protein: ENSMUSP00000122780
Gene: ENSMUSG00000061577

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000166802
AA Change: D83G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000132628
Gene: ENSMUSG00000061577
AA Change: D83G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 87 95 N/A INTRINSIC
GPS 181 234 1.37e-14 SMART
Pfam:7tm_2 241 495 1.3e-36 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp C T 16: 56,394,807 (GRCm39) Q172* probably null Het
Aga G A 8: 53,973,348 (GRCm39) D249N possibly damaging Het
Aifm3 A G 16: 17,318,397 (GRCm39) Q170R probably null Het
Cdh2 T A 18: 16,760,661 (GRCm39) N512Y probably damaging Het
Chd8 A G 14: 52,472,648 (GRCm39) I385T probably benign Het
Clic6 A G 16: 92,296,206 (GRCm39) K289E probably benign Het
Ctcf G T 8: 106,403,842 (GRCm39) probably benign Het
Fat1 T C 8: 45,488,628 (GRCm39) Y3447H probably benign Het
Fhip1a A T 3: 85,580,344 (GRCm39) D620E probably benign Het
Fmo2 T A 1: 162,704,490 (GRCm39) Q472L probably damaging Het
Gcnt3 C A 9: 69,941,444 (GRCm39) G375W probably damaging Het
Golga3 T A 5: 110,336,612 (GRCm39) V417E probably benign Het
Hivep3 T C 4: 119,952,641 (GRCm39) L319P probably benign Het
Kctd13 A G 7: 126,541,504 (GRCm39) K248R possibly damaging Het
Magel2 G A 7: 62,029,946 (GRCm39) R950H unknown Het
Niban1 T A 1: 151,447,296 (GRCm39) S6T probably benign Het
Nmt2 A G 2: 3,315,750 (GRCm39) I247V probably benign Het
Or14a256 T G 7: 86,264,872 (GRCm39) H327P probably benign Het
Or1e30 T A 11: 73,678,560 (GRCm39) N265K probably benign Het
Pcdhb12 T C 18: 37,570,099 (GRCm39) V415A probably benign Het
Pip5k1c C A 10: 81,153,155 (GRCm39) probably null Het
Prr27 T A 5: 87,990,518 (GRCm39) N43K probably benign Het
Rgs11 G A 17: 26,426,605 (GRCm39) V279I probably benign Het
Sec24a A T 11: 51,603,014 (GRCm39) probably null Het
Srek1ip1 C A 13: 104,973,984 (GRCm39) H130Q possibly damaging Het
Trio C T 15: 27,841,935 (GRCm39) probably benign Het
Ttn A G 2: 76,608,614 (GRCm39) probably benign Het
Vmn2r65 C A 7: 84,589,549 (GRCm39) S789I probably damaging Het
Zbtb17 A G 4: 141,192,399 (GRCm39) Q448R probably damaging Het
Other mutations in Adgrg5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01340:Adgrg5 APN 8 95,664,257 (GRCm39) missense probably damaging 1.00
R0483:Adgrg5 UTSW 8 95,660,136 (GRCm39) missense possibly damaging 0.73
R0539:Adgrg5 UTSW 8 95,665,260 (GRCm39) missense probably damaging 1.00
R0580:Adgrg5 UTSW 8 95,663,972 (GRCm39) critical splice donor site probably null
R0650:Adgrg5 UTSW 8 95,660,785 (GRCm39) critical splice donor site probably null
R0652:Adgrg5 UTSW 8 95,660,785 (GRCm39) critical splice donor site probably null
R0828:Adgrg5 UTSW 8 95,668,413 (GRCm39) splice site probably null
R1546:Adgrg5 UTSW 8 95,668,258 (GRCm39) missense probably benign 0.27
R1567:Adgrg5 UTSW 8 95,664,326 (GRCm39) missense probably damaging 0.97
R1695:Adgrg5 UTSW 8 95,664,373 (GRCm39) missense probably damaging 1.00
R1753:Adgrg5 UTSW 8 95,668,680 (GRCm39) missense possibly damaging 0.65
R1852:Adgrg5 UTSW 8 95,664,428 (GRCm39) missense probably damaging 1.00
R2018:Adgrg5 UTSW 8 95,661,108 (GRCm39) missense probably damaging 1.00
R2051:Adgrg5 UTSW 8 95,668,695 (GRCm39) missense probably benign 0.01
R2190:Adgrg5 UTSW 8 95,660,579 (GRCm39) missense probably damaging 1.00
R2299:Adgrg5 UTSW 8 95,665,204 (GRCm39) missense possibly damaging 0.88
R2568:Adgrg5 UTSW 8 95,660,649 (GRCm39) missense probably damaging 0.99
R4283:Adgrg5 UTSW 8 95,664,326 (GRCm39) missense probably benign 0.21
R4512:Adgrg5 UTSW 8 95,660,652 (GRCm39) missense possibly damaging 0.90
R4825:Adgrg5 UTSW 8 95,668,362 (GRCm39) missense possibly damaging 0.77
R5422:Adgrg5 UTSW 8 95,660,580 (GRCm39) missense probably damaging 1.00
R5427:Adgrg5 UTSW 8 95,661,730 (GRCm39) missense probably benign 0.27
R6186:Adgrg5 UTSW 8 95,660,652 (GRCm39) missense possibly damaging 0.90
R6522:Adgrg5 UTSW 8 95,668,696 (GRCm39) missense probably benign 0.13
R6608:Adgrg5 UTSW 8 95,668,348 (GRCm39) missense probably damaging 1.00
R6810:Adgrg5 UTSW 8 95,660,570 (GRCm39) missense probably damaging 0.97
R6816:Adgrg5 UTSW 8 95,668,311 (GRCm39) missense probably damaging 0.99
R7214:Adgrg5 UTSW 8 95,660,646 (GRCm39) missense
R7686:Adgrg5 UTSW 8 95,664,430 (GRCm39) missense
R7955:Adgrg5 UTSW 8 95,664,325 (GRCm39) missense
R9383:Adgrg5 UTSW 8 95,661,162 (GRCm39) missense
R9653:Adgrg5 UTSW 8 95,663,864 (GRCm39) missense
R9729:Adgrg5 UTSW 8 95,668,133 (GRCm39) missense
X0027:Adgrg5 UTSW 8 95,663,966 (GRCm39) missense probably benign 0.07
Z1176:Adgrg5 UTSW 8 95,661,779 (GRCm39) missense
Posted On 2015-04-16