Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02619:Or4b13'

300763

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or4b13

Ensembl Gene

ENSMUSG00000075063

Gene Name

olfactory receptor family 4 subfamily B member 13

Synonyms

K20, Olfr142, GA_x6K02T2Q125-51607674-51606757, MOR227-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL02619

Quality Score

Status

Chromosome

Chromosomal Location

90082413-90083330 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 90082849 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Asparagine at position 161 (T161N)

Ref Sequence

ENSEMBL: ENSMUSP00000150216 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099752] [ENSMUST00000213968]

AlphaFold

Q60881

Predicted Effect

probably damaging
Transcript: ENSMUST00000099752
AA Change: T161N

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000097341
Gene: ENSMUSG00000075063
AA Change: T161N

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	303	4.3e-53	PFAM
Pfam:7TM_GPCR_Srsx	33	300	3e-6	PFAM
Pfam:7tm_1	39	285	5.8e-24	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000213968
AA Change: T161N

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahctf1	C	T	1: 179,620,016 (GRCm39)	G220E	possibly damaging	Het
Arhgef10l	A	G	4: 140,321,504 (GRCm39)	I101T	probably benign	Het
Armc8	T	C	9: 99,409,122 (GRCm39)		probably benign	Het
Camkk2	A	T	5: 122,902,298 (GRCm39)	C4S	probably damaging	Het
Ccdc174	T	A	6: 91,876,538 (GRCm39)	D458E	possibly damaging	Het
Cercam	A	G	2: 29,770,686 (GRCm39)	N419S	probably benign	Het
Clca3a2	T	C	3: 144,512,083 (GRCm39)	N551S	probably damaging	Het
Cldn18	T	A	9: 99,580,988 (GRCm39)	I87F	probably damaging	Het
Ctso	T	A	3: 81,848,836 (GRCm39)		probably benign	Het
Ddhd2	C	A	8: 26,236,981 (GRCm39)		probably null	Het
Dscaml1	T	A	9: 45,359,094 (GRCm39)	Y118N	probably damaging	Het
Ece1	C	T	4: 137,666,044 (GRCm39)	A296V	probably benign	Het
Fbxo40	T	A	16: 36,790,766 (GRCm39)	I115F	possibly damaging	Het
Fkbp9	T	A	6: 56,827,609 (GRCm39)	N143K	probably damaging	Het
Foxk2	G	T	11: 121,190,402 (GRCm39)		probably benign	Het
Ggnbp1	A	G	17: 27,248,529 (GRCm39)	K33E	probably benign	Het
Hace1	A	T	10: 45,547,530 (GRCm39)		probably benign	Het
Hk3	A	T	13: 55,162,107 (GRCm39)	C133S	probably damaging	Het
Kbtbd3	C	T	9: 4,331,252 (GRCm39)	A542V	probably damaging	Het
Lrch2	A	C	X: 146,263,537 (GRCm39)	V363G	probably damaging	Het
Lrch2	C	T	X: 146,302,131 (GRCm39)	C264Y	probably damaging	Het
Lrrc56	C	A	7: 140,787,546 (GRCm39)		probably benign	Het
Lrtm2	C	T	6: 119,294,199 (GRCm39)	V311M	probably damaging	Het
N4bp1	G	T	8: 87,587,529 (GRCm39)	Q470K	probably benign	Het
Naa15	A	C	3: 51,367,552 (GRCm39)	D575A	probably benign	Het
Ncaph	A	T	2: 126,969,456 (GRCm39)	V69D	probably damaging	Het
Nlrp5	G	A	7: 23,123,489 (GRCm39)		probably null	Het
Nmbr	A	G	10: 14,636,331 (GRCm39)	D100G	probably damaging	Het
Ofcc1	C	T	13: 40,250,553 (GRCm39)	V588M	possibly damaging	Het
Or5p4	C	A	7: 107,680,949 (GRCm39)		probably benign	Het
Osmr	C	A	15: 6,871,475 (GRCm39)	R314M	probably damaging	Het
Pcdhb16	C	T	18: 37,611,270 (GRCm39)	Q77*	probably null	Het
Pglyrp4	G	A	3: 90,642,955 (GRCm39)		probably null	Het
Ptprh	A	G	7: 4,552,498 (GRCm39)	F922S	probably damaging	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Rp1	T	A	1: 4,418,673 (GRCm39)	Q813L	possibly damaging	Het
Sgtb	A	G	13: 104,254,922 (GRCm39)	N64S	probably benign	Het
Slc5a12	T	C	2: 110,471,201 (GRCm39)	V481A	probably benign	Het
Slitrk1	A	G	14: 109,149,349 (GRCm39)	V454A	probably benign	Het
Sntg2	C	A	12: 30,317,025 (GRCm39)		probably null	Het
Synj1	C	T	16: 90,770,933 (GRCm39)	V499I	probably damaging	Het
Tmco1	T	C	1: 167,153,597 (GRCm39)		probably benign	Het
Tmem38b	T	C	4: 53,848,871 (GRCm39)	I92T	probably damaging	Het
Tmem9	T	C	1: 135,955,145 (GRCm39)	V93A	probably benign	Het
Ttn	T	A	2: 76,625,582 (GRCm39)	R15080S	possibly damaging	Het
Ube2e3	T	C	2: 78,749,065 (GRCm39)	I138T	probably damaging	Het
Urgcp	A	G	11: 5,665,752 (GRCm39)	I862T	possibly damaging	Het
Vmn1r68	A	T	7: 10,261,603 (GRCm39)	I165N	probably benign	Het
Washc4	G	A	10: 83,394,717 (GRCm39)	V316I	possibly damaging	Het
Zfp111	A	T	7: 23,899,113 (GRCm39)	L166Q	possibly damaging	Het
Zfyve1	A	T	12: 83,597,718 (GRCm39)		probably benign	Het
Zscan18	A	G	7: 12,508,793 (GRCm39)		probably benign	Het

Other mutations in Or4b13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01622:Or4b13	APN	2	90,082,953 (GRCm39)	missense	probably damaging	1.00
IGL01623:Or4b13	APN	2	90,082,953 (GRCm39)	missense	probably damaging	1.00
IGL01810:Or4b13	APN	2	90,082,476 (GRCm39)	nonsense	probably null
IGL01918:Or4b13	APN	2	90,082,675 (GRCm39)	missense	probably damaging	1.00
IGL02732:Or4b13	APN	2	90,082,652 (GRCm39)	missense	probably damaging	1.00
IGL02738:Or4b13	APN	2	90,082,699 (GRCm39)	missense	possibly damaging	0.82
IGL02795:Or4b13	APN	2	90,082,906 (GRCm39)	missense	probably damaging	1.00
IGL02830:Or4b13	APN	2	90,083,125 (GRCm39)	missense	probably damaging	1.00
R0601:Or4b13	UTSW	2	90,083,278 (GRCm39)	missense	probably benign	0.05
R2004:Or4b13	UTSW	2	90,083,036 (GRCm39)	missense	probably benign	0.04
R2136:Or4b13	UTSW	2	90,082,597 (GRCm39)	missense	probably damaging	0.98
R2377:Or4b13	UTSW	2	90,083,255 (GRCm39)	missense	probably damaging	1.00
R3615:Or4b13	UTSW	2	90,082,753 (GRCm39)	missense	possibly damaging	0.94
R3616:Or4b13	UTSW	2	90,082,753 (GRCm39)	missense	possibly damaging	0.94
R3777:Or4b13	UTSW	2	90,082,969 (GRCm39)	missense	probably damaging	1.00
R4763:Or4b13	UTSW	2	90,082,807 (GRCm39)	missense	probably damaging	1.00
R4765:Or4b13	UTSW	2	90,082,807 (GRCm39)	missense	probably damaging	1.00
R5421:Or4b13	UTSW	2	90,083,089 (GRCm39)	missense	probably benign	0.01
R5426:Or4b13	UTSW	2	90,082,955 (GRCm39)	nonsense	probably null
R6063:Or4b13	UTSW	2	90,082,771 (GRCm39)	missense	probably benign	0.40
R6717:Or4b13	UTSW	2	90,082,868 (GRCm39)	missense	probably benign	0.00
R6931:Or4b13	UTSW	2	90,083,121 (GRCm39)	nonsense	probably null
R6936:Or4b13	UTSW	2	90,082,678 (GRCm39)	missense	probably benign	0.17
R7013:Or4b13	UTSW	2	90,082,441 (GRCm39)	missense	possibly damaging	0.87
R7091:Or4b13	UTSW	2	90,082,807 (GRCm39)	missense	probably damaging	1.00
R7247:Or4b13	UTSW	2	90,083,165 (GRCm39)	missense	probably damaging	1.00
R8169:Or4b13	UTSW	2	90,082,442 (GRCm39)	nonsense	probably null
R8345:Or4b13	UTSW	2	90,082,561 (GRCm39)	missense	possibly damaging	0.50
R9222:Or4b13	UTSW	2	90,082,820 (GRCm39)	missense	possibly damaging	0.95

Posted On

2015-04-16