Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02619:Foxk2'

300809

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Foxk2

Ensembl Gene

ENSMUSG00000039275

Gene Name

forkhead box K2

Synonyms

1110054H05Rik, Ilf1, 5730434B08Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02619

Quality Score

Status

Chromosome

Chromosomal Location

121150816-121200722 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to T at 121190402 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000101719 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106113]

AlphaFold

Q3UCQ1

Predicted Effect

probably benign
Transcript: ENSMUST00000106113

SMART Domains

Protein: ENSMUSP00000101719
Gene: ENSMUSG00000039275

Domain	Start	End	E-Value	Type
low complexity region	2	32	N/A	INTRINSIC
FHA	47	119	9.96e-10	SMART
FH	247	338	2.2e-52	SMART
low complexity region	440	465	N/A	INTRINSIC
low complexity region	486	498	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151492

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153579

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahctf1	C	T	1: 179,620,016 (GRCm39)	G220E	possibly damaging	Het
Arhgef10l	A	G	4: 140,321,504 (GRCm39)	I101T	probably benign	Het
Armc8	T	C	9: 99,409,122 (GRCm39)		probably benign	Het
Camkk2	A	T	5: 122,902,298 (GRCm39)	C4S	probably damaging	Het
Ccdc174	T	A	6: 91,876,538 (GRCm39)	D458E	possibly damaging	Het
Cercam	A	G	2: 29,770,686 (GRCm39)	N419S	probably benign	Het
Clca3a2	T	C	3: 144,512,083 (GRCm39)	N551S	probably damaging	Het
Cldn18	T	A	9: 99,580,988 (GRCm39)	I87F	probably damaging	Het
Ctso	T	A	3: 81,848,836 (GRCm39)		probably benign	Het
Ddhd2	C	A	8: 26,236,981 (GRCm39)		probably null	Het
Dscaml1	T	A	9: 45,359,094 (GRCm39)	Y118N	probably damaging	Het
Ece1	C	T	4: 137,666,044 (GRCm39)	A296V	probably benign	Het
Fbxo40	T	A	16: 36,790,766 (GRCm39)	I115F	possibly damaging	Het
Fkbp9	T	A	6: 56,827,609 (GRCm39)	N143K	probably damaging	Het
Ggnbp1	A	G	17: 27,248,529 (GRCm39)	K33E	probably benign	Het
Hace1	A	T	10: 45,547,530 (GRCm39)		probably benign	Het
Hk3	A	T	13: 55,162,107 (GRCm39)	C133S	probably damaging	Het
Kbtbd3	C	T	9: 4,331,252 (GRCm39)	A542V	probably damaging	Het
Lrch2	A	C	X: 146,263,537 (GRCm39)	V363G	probably damaging	Het
Lrch2	C	T	X: 146,302,131 (GRCm39)	C264Y	probably damaging	Het
Lrrc56	C	A	7: 140,787,546 (GRCm39)		probably benign	Het
Lrtm2	C	T	6: 119,294,199 (GRCm39)	V311M	probably damaging	Het
N4bp1	G	T	8: 87,587,529 (GRCm39)	Q470K	probably benign	Het
Naa15	A	C	3: 51,367,552 (GRCm39)	D575A	probably benign	Het
Ncaph	A	T	2: 126,969,456 (GRCm39)	V69D	probably damaging	Het
Nlrp5	G	A	7: 23,123,489 (GRCm39)		probably null	Het
Nmbr	A	G	10: 14,636,331 (GRCm39)	D100G	probably damaging	Het
Ofcc1	C	T	13: 40,250,553 (GRCm39)	V588M	possibly damaging	Het
Or4b13	G	T	2: 90,082,849 (GRCm39)	T161N	probably damaging	Het
Or5p4	C	A	7: 107,680,949 (GRCm39)		probably benign	Het
Osmr	C	A	15: 6,871,475 (GRCm39)	R314M	probably damaging	Het
Pcdhb16	C	T	18: 37,611,270 (GRCm39)	Q77*	probably null	Het
Pglyrp4	G	A	3: 90,642,955 (GRCm39)		probably null	Het
Ptprh	A	G	7: 4,552,498 (GRCm39)	F922S	probably damaging	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Rp1	T	A	1: 4,418,673 (GRCm39)	Q813L	possibly damaging	Het
Sgtb	A	G	13: 104,254,922 (GRCm39)	N64S	probably benign	Het
Slc5a12	T	C	2: 110,471,201 (GRCm39)	V481A	probably benign	Het
Slitrk1	A	G	14: 109,149,349 (GRCm39)	V454A	probably benign	Het
Sntg2	C	A	12: 30,317,025 (GRCm39)		probably null	Het
Synj1	C	T	16: 90,770,933 (GRCm39)	V499I	probably damaging	Het
Tmco1	T	C	1: 167,153,597 (GRCm39)		probably benign	Het
Tmem38b	T	C	4: 53,848,871 (GRCm39)	I92T	probably damaging	Het
Tmem9	T	C	1: 135,955,145 (GRCm39)	V93A	probably benign	Het
Ttn	T	A	2: 76,625,582 (GRCm39)	R15080S	possibly damaging	Het
Ube2e3	T	C	2: 78,749,065 (GRCm39)	I138T	probably damaging	Het
Urgcp	A	G	11: 5,665,752 (GRCm39)	I862T	possibly damaging	Het
Vmn1r68	A	T	7: 10,261,603 (GRCm39)	I165N	probably benign	Het
Washc4	G	A	10: 83,394,717 (GRCm39)	V316I	possibly damaging	Het
Zfp111	A	T	7: 23,899,113 (GRCm39)	L166Q	possibly damaging	Het
Zfyve1	A	T	12: 83,597,718 (GRCm39)		probably benign	Het
Zscan18	A	G	7: 12,508,793 (GRCm39)		probably benign	Het

Other mutations in Foxk2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00339:Foxk2	APN	11	121,190,560 (GRCm39)	missense	probably damaging	1.00
IGL00502:Foxk2	APN	11	121,187,925 (GRCm39)	splice site	probably benign
IGL03067:Foxk2	APN	11	121,176,394 (GRCm39)	missense	possibly damaging	0.87
R1843:Foxk2	UTSW	11	121,176,363 (GRCm39)	missense	probably benign	0.01
R2153:Foxk2	UTSW	11	121,151,213 (GRCm39)	missense	probably benign	0.08
R2847:Foxk2	UTSW	11	121,151,317 (GRCm39)	small insertion	probably benign
R3770:Foxk2	UTSW	11	121,151,317 (GRCm39)	small insertion	probably benign
R4024:Foxk2	UTSW	11	121,176,439 (GRCm39)	missense	possibly damaging	0.67
R6958:Foxk2	UTSW	11	121,190,563 (GRCm39)	missense	probably benign	0.16
R6968:Foxk2	UTSW	11	121,151,308 (GRCm39)	missense	possibly damaging	0.87
R7558:Foxk2	UTSW	11	121,178,884 (GRCm39)	missense	probably benign	0.00
R7736:Foxk2	UTSW	11	121,190,473 (GRCm39)	missense	possibly damaging	0.92
R7902:Foxk2	UTSW	11	121,190,553 (GRCm39)	missense	probably benign

Posted On

2015-04-16