Incidental Mutation 'IGL02622:Fbxw19'
ID 300880
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw19
Ensembl Gene ENSMUSG00000074061
Gene Name F-box and WD-40 domain protein 19
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # IGL02622
Quality Score
Status
Chromosome 9
Chromosomal Location 109307575-109324931 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 109322602 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 123 (M123L)
Ref Sequence ENSEMBL: ENSMUSP00000075918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076617]
AlphaFold Q8C2W8
Predicted Effect probably benign
Transcript: ENSMUST00000076617
AA Change: M123L

PolyPhen 2 Score 0.216 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000075918
Gene: ENSMUSG00000074061
AA Change: M123L

DomainStartEndE-ValueType
FBOX 5 45 1.8e-6 SMART
SCOP:d1gxra_ 87 284 3e-5 SMART
Blast:WD40 137 176 8e-8 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik C T 5: 109,887,101 (GRCm39) V32M possibly damaging Het
Abca1 T C 4: 53,034,046 (GRCm39) D2228G probably damaging Het
Actr5 A G 2: 158,480,728 (GRCm39) K582R probably benign Het
Armc8 T C 9: 99,409,122 (GRCm39) probably benign Het
Atp7b T C 8: 22,518,454 (GRCm39) D128G possibly damaging Het
Cemip C A 7: 83,613,383 (GRCm39) G605V probably damaging Het
Cep112 A G 11: 108,409,509 (GRCm39) H133R probably benign Het
Cops3 C T 11: 59,723,864 (GRCm39) D98N probably benign Het
Crlf3 T C 11: 79,950,150 (GRCm39) D160G probably damaging Het
Csn1s1 T C 5: 87,825,501 (GRCm39) probably null Het
Ddx60 C A 8: 62,395,470 (GRCm39) probably null Het
Depdc1a T A 3: 159,221,147 (GRCm39) N159K probably benign Het
Dsg3 A T 18: 20,662,004 (GRCm39) probably benign Het
Eif4g3 A C 4: 137,824,677 (GRCm39) probably benign Het
Ercc6l2 T A 13: 64,001,437 (GRCm39) probably null Het
Fus T A 7: 127,584,794 (GRCm39) L100H probably damaging Het
Gm29247 A G 1: 44,146,269 (GRCm39) probably benign Het
Gucy2e T C 11: 69,115,857 (GRCm39) T842A probably damaging Het
Inpp4a A T 1: 37,418,115 (GRCm39) Q519L probably benign Het
Kcnip1 C A 11: 33,593,290 (GRCm39) probably benign Het
Lyst T A 13: 13,855,975 (GRCm39) L2432H probably damaging Het
Mastl A G 2: 23,022,857 (GRCm39) V622A probably benign Het
Myh15 A G 16: 48,997,317 (GRCm39) T1712A probably benign Het
Nlrp1a T C 11: 71,013,826 (GRCm39) T475A possibly damaging Het
Nr4a3 G A 4: 48,051,649 (GRCm39) M134I probably benign Het
Or2a56 T G 6: 42,932,663 (GRCm39) V77G probably damaging Het
Or52m1 T A 7: 102,290,290 (GRCm39) L279Q probably damaging Het
Or5p60 T A 7: 107,723,595 (GRCm39) I292F probably damaging Het
Paqr6 T G 3: 88,273,085 (GRCm39) I52S probably damaging Het
Pcdhb4 T A 18: 37,442,721 (GRCm39) L677Q probably benign Het
Phax C T 18: 56,717,372 (GRCm39) R250* probably null Het
Pkn3 A G 2: 29,973,158 (GRCm39) D356G probably benign Het
Pnpla2 T C 7: 141,035,285 (GRCm39) L29P probably damaging Het
Rad18 G A 6: 112,664,948 (GRCm39) T62I probably damaging Het
Riok3 C T 18: 12,276,017 (GRCm39) R238C probably benign Het
Ror2 C T 13: 53,264,764 (GRCm39) S764N probably damaging Het
Sccpdh G T 1: 179,504,025 (GRCm39) G125W probably damaging Het
Skint11 T A 4: 114,051,925 (GRCm39) L91H probably damaging Het
Slc25a45 A G 19: 5,928,725 (GRCm39) probably benign Het
Slco2a1 C T 9: 102,954,128 (GRCm39) Q370* probably null Het
Szt2 A G 4: 118,250,087 (GRCm39) S474P probably damaging Het
Tchh C A 3: 93,350,719 (GRCm39) T53K probably damaging Het
Tiam1 T C 16: 89,595,588 (GRCm39) T1298A possibly damaging Het
Tmem161a C T 8: 70,633,887 (GRCm39) Q183* probably null Het
Trim26 C A 17: 37,161,797 (GRCm39) A72E probably damaging Het
Trmt11 A T 10: 30,435,169 (GRCm39) I330K probably benign Het
Tspan1 A G 4: 116,021,052 (GRCm39) probably benign Het
Ubr4 C A 4: 139,194,561 (GRCm39) C4286* probably null Het
Unc13a T C 8: 72,105,158 (GRCm39) probably null Het
Vmn1r20 T A 6: 57,409,583 (GRCm39) F303Y probably damaging Het
Washc2 T C 6: 116,190,979 (GRCm39) probably benign Het
Xab2 C T 8: 3,661,699 (GRCm39) D585N probably benign Het
Ythdc2 C T 18: 44,993,001 (GRCm39) L791F probably damaging Het
Zfp319 C A 8: 96,055,589 (GRCm39) V205F probably damaging Het
Zscan25 A T 5: 145,227,512 (GRCm39) H392L probably damaging Het
Zswim6 A T 13: 107,884,786 (GRCm39) noncoding transcript Het
Other mutations in Fbxw19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01094:Fbxw19 APN 9 109,322,614 (GRCm39) missense probably benign 0.03
IGL01878:Fbxw19 APN 9 109,312,347 (GRCm39) splice site probably benign
IGL02752:Fbxw19 APN 9 109,323,709 (GRCm39) missense probably benign 0.07
IGL02795:Fbxw19 APN 9 109,324,886 (GRCm39) missense possibly damaging 0.52
IGL03401:Fbxw19 APN 9 109,324,038 (GRCm39) critical splice donor site probably null
R0402:Fbxw19 UTSW 9 109,313,493 (GRCm39) missense probably benign 0.00
R0423:Fbxw19 UTSW 9 109,315,134 (GRCm39) missense probably benign 0.22
R0466:Fbxw19 UTSW 9 109,307,717 (GRCm39) missense probably benign 0.32
R0513:Fbxw19 UTSW 9 109,310,621 (GRCm39) splice site probably null
R1538:Fbxw19 UTSW 9 109,324,056 (GRCm39) missense probably damaging 1.00
R1768:Fbxw19 UTSW 9 109,323,840 (GRCm39) nonsense probably null
R1869:Fbxw19 UTSW 9 109,311,100 (GRCm39) missense probably benign 0.11
R1933:Fbxw19 UTSW 9 109,310,718 (GRCm39) missense probably benign 0.20
R1960:Fbxw19 UTSW 9 109,315,004 (GRCm39) missense probably benign
R2288:Fbxw19 UTSW 9 109,322,636 (GRCm39) missense probably damaging 0.99
R2877:Fbxw19 UTSW 9 109,315,038 (GRCm39) missense probably damaging 1.00
R2878:Fbxw19 UTSW 9 109,315,038 (GRCm39) missense probably damaging 1.00
R4778:Fbxw19 UTSW 9 109,323,714 (GRCm39) missense probably damaging 1.00
R5192:Fbxw19 UTSW 9 109,313,496 (GRCm39) missense probably benign 0.01
R5196:Fbxw19 UTSW 9 109,313,496 (GRCm39) missense probably benign 0.01
R5533:Fbxw19 UTSW 9 109,315,133 (GRCm39) missense probably benign 0.00
R6107:Fbxw19 UTSW 9 109,324,834 (GRCm39) missense probably damaging 1.00
R6333:Fbxw19 UTSW 9 109,323,751 (GRCm39) missense probably benign 0.01
R6820:Fbxw19 UTSW 9 109,311,079 (GRCm39) missense probably benign 0.07
R7631:Fbxw19 UTSW 9 109,311,069 (GRCm39) missense probably damaging 1.00
R7651:Fbxw19 UTSW 9 109,323,714 (GRCm39) missense probably damaging 1.00
R8669:Fbxw19 UTSW 9 109,313,482 (GRCm39) missense probably benign 0.26
R8678:Fbxw19 UTSW 9 109,312,376 (GRCm39) nonsense probably null
R9121:Fbxw19 UTSW 9 109,324,890 (GRCm39) missense probably damaging 1.00
R9256:Fbxw19 UTSW 9 109,310,641 (GRCm39) missense probably damaging 0.99
R9324:Fbxw19 UTSW 9 109,313,440 (GRCm39) missense possibly damaging 0.57
R9393:Fbxw19 UTSW 9 109,324,873 (GRCm39) missense probably damaging 1.00
R9408:Fbxw19 UTSW 9 109,315,101 (GRCm39) missense probably benign
Z1176:Fbxw19 UTSW 9 109,310,650 (GRCm39) missense probably benign 0.00
Posted On 2015-04-16