Incidental Mutation 'IGL02622:Tmem161a'
| ID |
300884 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tmem161a
|
| Ensembl Gene |
ENSMUSG00000002342 |
| Gene Name |
transmembrane protein 161A |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.102)
|
| Stock # |
IGL02622
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
70625006-70636331 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 70633887 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 183
(Q183*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138499
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000002413]
[ENSMUST00000063788]
[ENSMUST00000110127]
[ENSMUST00000182715]
[ENSMUST00000147656]
[ENSMUST00000182980]
[ENSMUST00000149105]
[ENSMUST00000182365]
|
| AlphaFold |
Q8VCA6 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000002413
AA Change: Q335*
|
| SMART Domains |
Protein: ENSMUSP00000002413
Gene: ENSMUSG00000002342
AA Change: Q335*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tmemb_161AB
|
2 |
478 |
6.8e-182 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063788
|
| SMART Domains |
Protein: ENSMUSP00000065903
Gene: ENSMUSG00000002346
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Mito_carr
|
29 |
122 |
3.4e-23 |
PFAM |
|
Pfam:Mito_carr
|
127 |
219 |
1.4e-26 |
PFAM |
|
Pfam:Mito_carr
|
222 |
316 |
3.8e-22 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110127
|
| SMART Domains |
Protein: ENSMUSP00000105754
Gene: ENSMUSG00000002346
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Mito_carr
|
29 |
122 |
1.6e-23 |
PFAM |
|
Pfam:Mito_carr
|
127 |
219 |
7.2e-27 |
PFAM |
|
Pfam:Mito_carr
|
222 |
317 |
3.3e-22 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123923
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125755
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125906
|
| SMART Domains |
Protein: ENSMUSP00000137791
Gene: ENSMUSG00000002342
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tmemb_161AB
|
1 |
119 |
8.7e-37 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126268
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000182715
AA Change: A172V
|
| SMART Domains |
Protein: ENSMUSP00000138432
Gene: ENSMUSG00000002342
AA Change: A172V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tmemb_161AB
|
2 |
45 |
3.3e-15 |
PFAM |
|
low complexity region
|
152 |
165 |
N/A |
INTRINSIC |
|
low complexity region
|
178 |
189 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000147656
AA Change: A303V
|
| SMART Domains |
Protein: ENSMUSP00000138017
Gene: ENSMUSG00000002342
AA Change: A303V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tmemb_161AB
|
2 |
270 |
4.6e-122 |
PFAM |
|
low complexity region
|
283 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
309 |
320 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000182980
AA Change: Q183*
|
| SMART Domains |
Protein: ENSMUSP00000138499
Gene: ENSMUSG00000002342
AA Change: Q183*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tmemb_161AB
|
1 |
328 |
4.6e-133 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000149105
AA Change: Q309*
|
| SMART Domains |
Protein: ENSMUSP00000123084
Gene: ENSMUSG00000002342
AA Change: Q309*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tmemb_161AB
|
1 |
95 |
5.1e-41 |
PFAM |
|
Pfam:Tmemb_161AB
|
93 |
454 |
9.5e-148 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133339
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133084
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139333
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000182942
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143543
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182365
|
| SMART Domains |
Protein: ENSMUSP00000138641
Gene: ENSMUSG00000002342
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tmemb_161AB
|
2 |
98 |
3.7e-42 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 56 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
C |
T |
5: 109,887,101 (GRCm39) |
V32M |
possibly damaging |
Het |
| Abca1 |
T |
C |
4: 53,034,046 (GRCm39) |
D2228G |
probably damaging |
Het |
| Actr5 |
A |
G |
2: 158,480,728 (GRCm39) |
K582R |
probably benign |
Het |
| Armc8 |
T |
C |
9: 99,409,122 (GRCm39) |
|
probably benign |
Het |
| Atp7b |
T |
C |
8: 22,518,454 (GRCm39) |
D128G |
possibly damaging |
Het |
| Cemip |
C |
A |
7: 83,613,383 (GRCm39) |
G605V |
probably damaging |
Het |
| Cep112 |
A |
G |
11: 108,409,509 (GRCm39) |
H133R |
probably benign |
Het |
| Cops3 |
C |
T |
11: 59,723,864 (GRCm39) |
D98N |
probably benign |
Het |
| Crlf3 |
T |
C |
11: 79,950,150 (GRCm39) |
D160G |
probably damaging |
Het |
| Csn1s1 |
T |
C |
5: 87,825,501 (GRCm39) |
|
probably null |
Het |
| Ddx60 |
C |
A |
8: 62,395,470 (GRCm39) |
|
probably null |
Het |
| Depdc1a |
T |
A |
3: 159,221,147 (GRCm39) |
N159K |
probably benign |
Het |
| Dsg3 |
A |
T |
18: 20,662,004 (GRCm39) |
|
probably benign |
Het |
| Eif4g3 |
A |
C |
4: 137,824,677 (GRCm39) |
|
probably benign |
Het |
| Ercc6l2 |
T |
A |
13: 64,001,437 (GRCm39) |
|
probably null |
Het |
| Fbxw19 |
T |
A |
9: 109,322,602 (GRCm39) |
M123L |
probably benign |
Het |
| Fus |
T |
A |
7: 127,584,794 (GRCm39) |
L100H |
probably damaging |
Het |
| Gm29247 |
A |
G |
1: 44,146,269 (GRCm39) |
|
probably benign |
Het |
| Gucy2e |
T |
C |
11: 69,115,857 (GRCm39) |
T842A |
probably damaging |
Het |
| Inpp4a |
A |
T |
1: 37,418,115 (GRCm39) |
Q519L |
probably benign |
Het |
| Kcnip1 |
C |
A |
11: 33,593,290 (GRCm39) |
|
probably benign |
Het |
| Lyst |
T |
A |
13: 13,855,975 (GRCm39) |
L2432H |
probably damaging |
Het |
| Mastl |
A |
G |
2: 23,022,857 (GRCm39) |
V622A |
probably benign |
Het |
| Myh15 |
A |
G |
16: 48,997,317 (GRCm39) |
T1712A |
probably benign |
Het |
| Nlrp1a |
T |
C |
11: 71,013,826 (GRCm39) |
T475A |
possibly damaging |
Het |
| Nr4a3 |
G |
A |
4: 48,051,649 (GRCm39) |
M134I |
probably benign |
Het |
| Or2a56 |
T |
G |
6: 42,932,663 (GRCm39) |
V77G |
probably damaging |
Het |
| Or52m1 |
T |
A |
7: 102,290,290 (GRCm39) |
L279Q |
probably damaging |
Het |
| Or5p60 |
T |
A |
7: 107,723,595 (GRCm39) |
I292F |
probably damaging |
Het |
| Paqr6 |
T |
G |
3: 88,273,085 (GRCm39) |
I52S |
probably damaging |
Het |
| Pcdhb4 |
T |
A |
18: 37,442,721 (GRCm39) |
L677Q |
probably benign |
Het |
| Phax |
C |
T |
18: 56,717,372 (GRCm39) |
R250* |
probably null |
Het |
| Pkn3 |
A |
G |
2: 29,973,158 (GRCm39) |
D356G |
probably benign |
Het |
| Pnpla2 |
T |
C |
7: 141,035,285 (GRCm39) |
L29P |
probably damaging |
Het |
| Rad18 |
G |
A |
6: 112,664,948 (GRCm39) |
T62I |
probably damaging |
Het |
| Riok3 |
C |
T |
18: 12,276,017 (GRCm39) |
R238C |
probably benign |
Het |
| Ror2 |
C |
T |
13: 53,264,764 (GRCm39) |
S764N |
probably damaging |
Het |
| Sccpdh |
G |
T |
1: 179,504,025 (GRCm39) |
G125W |
probably damaging |
Het |
| Skint11 |
T |
A |
4: 114,051,925 (GRCm39) |
L91H |
probably damaging |
Het |
| Slc25a45 |
A |
G |
19: 5,928,725 (GRCm39) |
|
probably benign |
Het |
| Slco2a1 |
C |
T |
9: 102,954,128 (GRCm39) |
Q370* |
probably null |
Het |
| Szt2 |
A |
G |
4: 118,250,087 (GRCm39) |
S474P |
probably damaging |
Het |
| Tchh |
C |
A |
3: 93,350,719 (GRCm39) |
T53K |
probably damaging |
Het |
| Tiam1 |
T |
C |
16: 89,595,588 (GRCm39) |
T1298A |
possibly damaging |
Het |
| Trim26 |
C |
A |
17: 37,161,797 (GRCm39) |
A72E |
probably damaging |
Het |
| Trmt11 |
A |
T |
10: 30,435,169 (GRCm39) |
I330K |
probably benign |
Het |
| Tspan1 |
A |
G |
4: 116,021,052 (GRCm39) |
|
probably benign |
Het |
| Ubr4 |
C |
A |
4: 139,194,561 (GRCm39) |
C4286* |
probably null |
Het |
| Unc13a |
T |
C |
8: 72,105,158 (GRCm39) |
|
probably null |
Het |
| Vmn1r20 |
T |
A |
6: 57,409,583 (GRCm39) |
F303Y |
probably damaging |
Het |
| Washc2 |
T |
C |
6: 116,190,979 (GRCm39) |
|
probably benign |
Het |
| Xab2 |
C |
T |
8: 3,661,699 (GRCm39) |
D585N |
probably benign |
Het |
| Ythdc2 |
C |
T |
18: 44,993,001 (GRCm39) |
L791F |
probably damaging |
Het |
| Zfp319 |
C |
A |
8: 96,055,589 (GRCm39) |
V205F |
probably damaging |
Het |
| Zscan25 |
A |
T |
5: 145,227,512 (GRCm39) |
H392L |
probably damaging |
Het |
| Zswim6 |
A |
T |
13: 107,884,786 (GRCm39) |
|
noncoding transcript |
Het |
|
| Other mutations in Tmem161a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02049:Tmem161a
|
APN |
8 |
70,631,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02425:Tmem161a
|
APN |
8 |
70,629,577 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02597:Tmem161a
|
APN |
8 |
70,634,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4431001:Tmem161a
|
UTSW |
8 |
70,634,674 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0498:Tmem161a
|
UTSW |
8 |
70,633,623 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1881:Tmem161a
|
UTSW |
8 |
70,633,435 (GRCm39) |
missense |
probably null |
1.00 |
|
R1970:Tmem161a
|
UTSW |
8 |
70,629,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1971:Tmem161a
|
UTSW |
8 |
70,629,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2027:Tmem161a
|
UTSW |
8 |
70,630,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2384:Tmem161a
|
UTSW |
8 |
70,630,204 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2870:Tmem161a
|
UTSW |
8 |
70,631,565 (GRCm39) |
intron |
probably benign |
|
|
R2872:Tmem161a
|
UTSW |
8 |
70,631,565 (GRCm39) |
intron |
probably benign |
|
|
R4271:Tmem161a
|
UTSW |
8 |
70,634,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4284:Tmem161a
|
UTSW |
8 |
70,630,076 (GRCm39) |
intron |
probably benign |
|
|
R4576:Tmem161a
|
UTSW |
8 |
70,634,713 (GRCm39) |
splice site |
probably null |
|
|
R4677:Tmem161a
|
UTSW |
8 |
70,633,597 (GRCm39) |
splice site |
probably null |
|
|
R6322:Tmem161a
|
UTSW |
8 |
70,634,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6823:Tmem161a
|
UTSW |
8 |
70,633,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Tmem161a
|
UTSW |
8 |
70,630,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7965:Tmem161a
|
UTSW |
8 |
70,630,154 (GRCm39) |
start gained |
probably benign |
|
|
R8269:Tmem161a
|
UTSW |
8 |
70,634,608 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8695:Tmem161a
|
UTSW |
8 |
70,627,047 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9261:Tmem161a
|
UTSW |
8 |
70,631,572 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9355:Tmem161a
|
UTSW |
8 |
70,633,821 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9657:Tmem161a
|
UTSW |
8 |
70,630,260 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation