Incidental Mutation 'IGL02623:Zfp119b'
ID300935
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp119b
Ensembl Gene ENSMUSG00000062101
Gene Namezinc finger protein 119b
SynonymsBC031441
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL02623
Quality Score
Status
Chromosome17
Chromosomal Location55938381-55949500 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 55939793 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 99 (E99G)
Ref Sequence ENSEMBL: ENSMUSP00000139791 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056147] [ENSMUST00000189452]
Predicted Effect possibly damaging
Transcript: ENSMUST00000056147
AA Change: E131G

PolyPhen 2 Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000058300
Gene: ENSMUSG00000062101
AA Change: E131G

DomainStartEndE-ValueType
KRAB 4 56 2e-14 SMART
ZnF_C2H2 155 175 2.82e1 SMART
ZnF_C2H2 287 309 1.1e-2 SMART
ZnF_C2H2 315 337 2.24e-3 SMART
ZnF_C2H2 343 365 5.14e-3 SMART
ZnF_C2H2 371 393 4.79e-3 SMART
ZnF_C2H2 399 421 1.12e-3 SMART
ZnF_C2H2 427 449 5.14e-3 SMART
ZnF_C2H2 455 477 7.37e-4 SMART
ZnF_C2H2 483 505 4.87e-4 SMART
ZnF_C2H2 511 533 1.25e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000189452
AA Change: E99G

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000139791
Gene: ENSMUSG00000062101
AA Change: E99G

DomainStartEndE-ValueType
Blast:KRAB 1 34 8e-11 BLAST
ZnF_C2H2 123 143 1.2e-1 SMART
ZnF_C2H2 255 277 4.7e-5 SMART
ZnF_C2H2 283 305 9.1e-6 SMART
ZnF_C2H2 311 333 2.2e-5 SMART
ZnF_C2H2 339 361 2e-5 SMART
ZnF_C2H2 367 389 4.7e-6 SMART
ZnF_C2H2 395 417 2.1e-5 SMART
ZnF_C2H2 423 445 3.2e-6 SMART
ZnF_C2H2 451 473 2e-6 SMART
ZnF_C2H2 479 501 5.2e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438H23Rik T A 16: 91,056,144 I35F probably benign Het
Acad10 A G 5: 121,629,930 V819A possibly damaging Het
Adgrd1 A T 5: 129,132,745 N279Y probably damaging Het
Aplp2 C A 9: 31,178,083 probably benign Het
Armc8 T C 9: 99,527,069 probably benign Het
B3gnt5 A G 16: 19,769,610 D193G probably damaging Het
Cacng1 A G 11: 107,704,319 F144S probably damaging Het
Dnm3 T A 1: 162,355,432 T105S probably damaging Het
Efcab6 T A 15: 83,879,448 I1228F probably damaging Het
Erc2 A G 14: 27,776,980 D271G probably damaging Het
Fat3 T C 9: 15,997,137 Y2523C probably damaging Het
Fhl4 A G 10: 85,098,171 F249L probably damaging Het
Gm17782 T C 17: 36,162,066 probably benign Het
Gm4787 A G 12: 81,378,728 Y219H probably damaging Het
Hk1 A G 10: 62,292,359 L328P probably benign Het
Hspa12a T A 19: 58,809,551 Y245F probably benign Het
Kbtbd12 T C 6: 88,618,389 Y153C probably damaging Het
Kcnd2 A T 6: 21,726,195 R562S probably benign Het
Lct T C 1: 128,308,251 S340G probably benign Het
Maats1 T A 16: 38,333,778 D135V possibly damaging Het
Mettl25 C A 10: 105,826,324 G262W probably damaging Het
Mindy3 G A 2: 12,364,483 Q142* probably null Het
Olfr1045 A T 2: 86,198,019 H244Q probably damaging Het
Optn T C 2: 5,035,022 E318G probably damaging Het
Pan2 T C 10: 128,312,899 S443P probably benign Het
Parva A G 7: 112,576,439 D259G probably damaging Het
Pkhd1l1 T A 15: 44,584,873 L3816Q probably damaging Het
Polq T C 16: 37,060,375 F967S probably benign Het
Prdm16 T C 4: 154,340,877 N817S probably damaging Het
Ptprt C A 2: 161,607,452 probably benign Het
Rbbp8nl T A 2: 180,281,443 S154C probably damaging Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Slit1 T C 19: 41,651,683 I169V probably damaging Het
Smyd4 G T 11: 75,390,064 probably benign Het
Tial1 A G 7: 128,443,883 Y326H probably benign Het
Tmem198b A G 10: 128,802,451 L81P probably damaging Het
Tmem94 T A 11: 115,796,401 C1115* probably null Het
Tns3 A G 11: 8,437,141 S1349P probably damaging Het
Wdr38 A T 2: 38,998,412 N7I probably damaging Het
Zfp106 A T 2: 120,545,914 probably null Het
Zfp462 T A 4: 55,012,986 C503S probably damaging Het
Zfyve19 G A 2: 119,212,015 probably null Het
Zxdc G T 6: 90,382,370 K661N probably damaging Het
Other mutations in Zfp119b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00545:Zfp119b APN 17 55939270 missense probably damaging 1.00
IGL01868:Zfp119b APN 17 55939866 missense possibly damaging 0.70
R0377:Zfp119b UTSW 17 55938671 missense probably damaging 1.00
R1833:Zfp119b UTSW 17 55939271 missense probably damaging 1.00
R2177:Zfp119b UTSW 17 55938639 missense probably damaging 1.00
R2297:Zfp119b UTSW 17 55939355 missense possibly damaging 0.46
R4273:Zfp119b UTSW 17 55938926 missense possibly damaging 0.79
R4801:Zfp119b UTSW 17 55939642 missense probably damaging 0.96
R4802:Zfp119b UTSW 17 55939642 missense probably damaging 0.96
R6525:Zfp119b UTSW 17 55939992 missense possibly damaging 0.96
R6644:Zfp119b UTSW 17 55939148 missense probably benign 0.21
R6950:Zfp119b UTSW 17 55939137 missense probably damaging 1.00
R6974:Zfp119b UTSW 17 55938564 missense probably benign 0.02
R7750:Zfp119b UTSW 17 55938682 missense probably damaging 1.00
RF020:Zfp119b UTSW 17 55939499 missense probably benign 0.00
Posted On2015-04-16