Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02623:Mettl25'

300952

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mettl25

Ensembl Gene

ENSMUSG00000036009

Gene Name

methyltransferase like 25

Synonyms

BC067068

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

IGL02623

Quality Score

Status

Chromosome

Chromosomal Location

105763189-105841380 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 105826324 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Tryptophan at position 262 (G262W)

Ref Sequence

ENSEMBL: ENSMUSP00000038665 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046638] [ENSMUST00000176040] [ENSMUST00000176924]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000046638
AA Change: G262W

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000038665
Gene: ENSMUSG00000036009
AA Change: G262W

Domain	Start	End	E-Value	Type
Pfam:Methyltransf_32	149	413	1.9e-30	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176040

Predicted Effect

probably benign
Transcript: ENSMUST00000176924

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438H23Rik	T	A	16: 91,056,144	I35F	probably benign	Het
Acad10	A	G	5: 121,629,930	V819A	possibly damaging	Het
Adgrd1	A	T	5: 129,132,745	N279Y	probably damaging	Het
Aplp2	C	A	9: 31,178,083		probably benign	Het
Armc8	T	C	9: 99,527,069		probably benign	Het
B3gnt5	A	G	16: 19,769,610	D193G	probably damaging	Het
Cacng1	A	G	11: 107,704,319	F144S	probably damaging	Het
Dnm3	T	A	1: 162,355,432	T105S	probably damaging	Het
Efcab6	T	A	15: 83,879,448	I1228F	probably damaging	Het
Erc2	A	G	14: 27,776,980	D271G	probably damaging	Het
Fat3	T	C	9: 15,997,137	Y2523C	probably damaging	Het
Fhl4	A	G	10: 85,098,171	F249L	probably damaging	Het
Gm17782	T	C	17: 36,162,066		probably benign	Het
Gm4787	A	G	12: 81,378,728	Y219H	probably damaging	Het
Hk1	A	G	10: 62,292,359	L328P	probably benign	Het
Hspa12a	T	A	19: 58,809,551	Y245F	probably benign	Het
Kbtbd12	T	C	6: 88,618,389	Y153C	probably damaging	Het
Kcnd2	A	T	6: 21,726,195	R562S	probably benign	Het
Lct	T	C	1: 128,308,251	S340G	probably benign	Het
Maats1	T	A	16: 38,333,778	D135V	possibly damaging	Het
Mindy3	G	A	2: 12,364,483	Q142*	probably null	Het
Olfr1045	A	T	2: 86,198,019	H244Q	probably damaging	Het
Optn	T	C	2: 5,035,022	E318G	probably damaging	Het
Pan2	T	C	10: 128,312,899	S443P	probably benign	Het
Parva	A	G	7: 112,576,439	D259G	probably damaging	Het
Pkhd1l1	T	A	15: 44,584,873	L3816Q	probably damaging	Het
Polq	T	C	16: 37,060,375	F967S	probably benign	Het
Prdm16	T	C	4: 154,340,877	N817S	probably damaging	Het
Ptprt	C	A	2: 161,607,452		probably benign	Het
Rbbp8nl	T	A	2: 180,281,443	S154C	probably damaging	Het
Ror2	C	T	13: 53,110,728	S764N	probably damaging	Het
Slit1	T	C	19: 41,651,683	I169V	probably damaging	Het
Smyd4	G	T	11: 75,390,064		probably benign	Het
Tial1	A	G	7: 128,443,883	Y326H	probably benign	Het
Tmem198b	A	G	10: 128,802,451	L81P	probably damaging	Het
Tmem94	T	A	11: 115,796,401	C1115*	probably null	Het
Tns3	A	G	11: 8,437,141	S1349P	probably damaging	Het
Wdr38	A	T	2: 38,998,412	N7I	probably damaging	Het
Zfp106	A	T	2: 120,545,914		probably null	Het
Zfp119b	T	C	17: 55,939,793	E99G	probably damaging	Het
Zfp462	T	A	4: 55,012,986	C503S	probably damaging	Het
Zfyve19	G	A	2: 119,212,015		probably null	Het
Zxdc	G	T	6: 90,382,370	K661N	probably damaging	Het

Other mutations in Mettl25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00310:Mettl25	APN	10	105826434	missense	probably benign
IGL00698:Mettl25	APN	10	105793340	missense	probably null	0.31
IGL00766:Mettl25	APN	10	105779582	splice site	probably benign
IGL01360:Mettl25	APN	10	105823197	missense	probably damaging	1.00
IGL01954:Mettl25	APN	10	105823207	missense	probably damaging	1.00
IGL02088:Mettl25	APN	10	105823250	missense	probably damaging	1.00
IGL03245:Mettl25	APN	10	105826497	missense	possibly damaging	0.86
IGL03134:Mettl25	UTSW	10	105826027	nonsense	probably null
R0238:Mettl25	UTSW	10	105826525	missense	probably damaging	1.00
R0238:Mettl25	UTSW	10	105826525	missense	probably damaging	1.00
R0239:Mettl25	UTSW	10	105826525	missense	probably damaging	1.00
R0239:Mettl25	UTSW	10	105826525	missense	probably damaging	1.00
R1297:Mettl25	UTSW	10	105823265	missense	probably benign	0.11
R1482:Mettl25	UTSW	10	105826590	missense	possibly damaging	0.61
R1526:Mettl25	UTSW	10	105832983	missense	possibly damaging	0.56
R1542:Mettl25	UTSW	10	105826120	missense	probably benign	0.04
R1589:Mettl25	UTSW	10	105779632	missense	probably damaging	1.00
R1901:Mettl25	UTSW	10	105826087	missense	probably damaging	0.96
R1902:Mettl25	UTSW	10	105826087	missense	probably damaging	0.96
R2016:Mettl25	UTSW	10	105797306	missense	probably benign	0.00
R2355:Mettl25	UTSW	10	105763455	missense	probably benign	0.00
R2920:Mettl25	UTSW	10	105765177	splice site	probably null
R3149:Mettl25	UTSW	10	105826353	missense	probably benign	0.00
R4547:Mettl25	UTSW	10	105826017	missense	probably damaging	1.00
R4646:Mettl25	UTSW	10	105826555	missense	probably damaging	1.00
R4652:Mettl25	UTSW	10	105779648	nonsense	probably null
R5020:Mettl25	UTSW	10	105826207	missense	possibly damaging	0.87
R5435:Mettl25	UTSW	10	105779586	critical splice donor site	probably null
R6947:Mettl25	UTSW	10	105826192	missense	probably benign	0.00
R7075:Mettl25	UTSW	10	105829924	missense	possibly damaging	0.68
R7729:Mettl25	UTSW	10	105766010	missense	probably benign	0.03
R8074:Mettl25	UTSW	10	105826080	missense	probably benign	0.02
R8108:Mettl25	UTSW	10	105823179	missense	possibly damaging	0.53
R8415:Mettl25	UTSW	10	105826141	missense	probably benign	0.05
R8937:Mettl25	UTSW	10	105765261	missense	probably benign	0.17
R8949:Mettl25	UTSW	10	105832853	missense	probably benign	0.00
R9497:Mettl25	UTSW	10	105841229	missense	probably damaging	0.98
R9772:Mettl25	UTSW	10	105797266	missense	probably benign
RF009:Mettl25	UTSW	10	105833239	intron	probably benign
Z1176:Mettl25	UTSW	10	105826098	missense	possibly damaging	0.95

Posted On

2015-04-16