Incidental Mutation 'IGL02623:Olfr1045'
ID300956
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1045
Ensembl Gene ENSMUSG00000075198
Gene Nameolfactory receptor 1045
SynonymsMOR185-2, GA_x6K02T2Q125-47672825-47671878
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.114) question?
Stock #IGL02623
Quality Score
Status
Chromosome2
Chromosomal Location86195910-86203009 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 86198019 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Glutamine at position 244 (H244Q)
Ref Sequence ENSEMBL: ENSMUSP00000148982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099904] [ENSMUST00000215763]
Predicted Effect probably damaging
Transcript: ENSMUST00000099904
AA Change: H244Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097488
Gene: ENSMUSG00000075198
AA Change: H244Q

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.2e-43 PFAM
Pfam:7tm_1 41 290 5.7e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215763
AA Change: H244Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216885
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438H23Rik T A 16: 91,056,144 I35F probably benign Het
Acad10 A G 5: 121,629,930 V819A possibly damaging Het
Adgrd1 A T 5: 129,132,745 N279Y probably damaging Het
Aplp2 C A 9: 31,178,083 probably benign Het
Armc8 T C 9: 99,527,069 probably benign Het
B3gnt5 A G 16: 19,769,610 D193G probably damaging Het
Cacng1 A G 11: 107,704,319 F144S probably damaging Het
Dnm3 T A 1: 162,355,432 T105S probably damaging Het
Efcab6 T A 15: 83,879,448 I1228F probably damaging Het
Erc2 A G 14: 27,776,980 D271G probably damaging Het
Fat3 T C 9: 15,997,137 Y2523C probably damaging Het
Fhl4 A G 10: 85,098,171 F249L probably damaging Het
Gm17782 T C 17: 36,162,066 probably benign Het
Gm4787 A G 12: 81,378,728 Y219H probably damaging Het
Hk1 A G 10: 62,292,359 L328P probably benign Het
Hspa12a T A 19: 58,809,551 Y245F probably benign Het
Kbtbd12 T C 6: 88,618,389 Y153C probably damaging Het
Kcnd2 A T 6: 21,726,195 R562S probably benign Het
Lct T C 1: 128,308,251 S340G probably benign Het
Maats1 T A 16: 38,333,778 D135V possibly damaging Het
Mettl25 C A 10: 105,826,324 G262W probably damaging Het
Mindy3 G A 2: 12,364,483 Q142* probably null Het
Optn T C 2: 5,035,022 E318G probably damaging Het
Pan2 T C 10: 128,312,899 S443P probably benign Het
Parva A G 7: 112,576,439 D259G probably damaging Het
Pkhd1l1 T A 15: 44,584,873 L3816Q probably damaging Het
Polq T C 16: 37,060,375 F967S probably benign Het
Prdm16 T C 4: 154,340,877 N817S probably damaging Het
Ptprt C A 2: 161,607,452 probably benign Het
Rbbp8nl T A 2: 180,281,443 S154C probably damaging Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Slit1 T C 19: 41,651,683 I169V probably damaging Het
Smyd4 G T 11: 75,390,064 probably benign Het
Tial1 A G 7: 128,443,883 Y326H probably benign Het
Tmem198b A G 10: 128,802,451 L81P probably damaging Het
Tmem94 T A 11: 115,796,401 C1115* probably null Het
Tns3 A G 11: 8,437,141 S1349P probably damaging Het
Wdr38 A T 2: 38,998,412 N7I probably damaging Het
Zfp106 A T 2: 120,545,914 probably null Het
Zfp119b T C 17: 55,939,793 E99G probably damaging Het
Zfp462 T A 4: 55,012,986 C503S probably damaging Het
Zfyve19 G A 2: 119,212,015 probably null Het
Zxdc G T 6: 90,382,370 K661N probably damaging Het
Other mutations in Olfr1045
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01350:Olfr1045 APN 2 86197805 makesense probably null
IGL01914:Olfr1045 APN 2 86198672 missense probably benign 0.45
IGL01991:Olfr1045 APN 2 86198533 missense probably benign 0.23
R0325:Olfr1045 UTSW 2 86198711 missense possibly damaging 0.51
R0730:Olfr1045 UTSW 2 86198725 missense probably benign 0.14
R1457:Olfr1045 UTSW 2 86198252 missense probably damaging 0.99
R2037:Olfr1045 UTSW 2 86197832 missense probably benign
R2121:Olfr1045 UTSW 2 86197996 missense possibly damaging 0.88
R2271:Olfr1045 UTSW 2 86197817 missense probably benign 0.00
R3836:Olfr1045 UTSW 2 86198662 missense probably benign 0.02
R4669:Olfr1045 UTSW 2 86197933 missense possibly damaging 0.90
R6082:Olfr1045 UTSW 2 86198317 missense probably damaging 0.97
R7326:Olfr1045 UTSW 2 86198573 missense probably damaging 1.00
R7463:Olfr1045 UTSW 2 86197838 missense probably benign
R7523:Olfr1045 UTSW 2 86198045 missense probably damaging 0.99
R7842:Olfr1045 UTSW 2 86198172 nonsense probably null
R7919:Olfr1045 UTSW 2 86198265 nonsense probably null
Posted On2015-04-16