Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02623:Tns3'

300961

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tns3

Ensembl Gene

ENSMUSG00000020422

Gene Name

tensin 3

Synonyms

TEM6, F830010I22Rik, Tens1

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.371) question?

Stock #

IGL02623

Quality Score

Status

Chromosome

Chromosomal Location

8431652-8664535 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 8437141 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 1349 (S1349P)

Ref Sequence

ENSEMBL: ENSMUSP00000020695 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020695]

AlphaFold

Q5SSZ5

Predicted Effect

probably damaging
Transcript: ENSMUST00000020695
AA Change: S1349P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000020695
Gene: ENSMUSG00000020422
AA Change: S1349P

Domain	Start	End	E-Value	Type
SCOP:d1d5ra2	1	171	5e-28	SMART
PTEN_C2	173	300	1.15e-48	SMART
low complexity region	854	864	N/A	INTRINSIC
low complexity region	1102	1126	N/A	INTRINSIC
SH2	1165	1268	1.32e-18	SMART
PTB	1301	1438	3.14e-24	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a null allele exhibit one third postnatal lethality, reduced body weight, growth retardation, smaller digestive tracts with defects in villi and enterocyte differentiation, abnormal lung morphology, and thinner bones with decreased chondrocyte proliferation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438H23Rik	T	A	16: 91,056,144 (GRCm38)	I35F	probably benign	Het
Acad10	A	G	5: 121,629,930 (GRCm38)	V819A	possibly damaging	Het
Adgrd1	A	T	5: 129,132,745 (GRCm38)	N279Y	probably damaging	Het
Aplp2	C	A	9: 31,178,083 (GRCm38)		probably benign	Het
Armc8	T	C	9: 99,527,069 (GRCm38)		probably benign	Het
B3gnt5	A	G	16: 19,769,610 (GRCm38)	D193G	probably damaging	Het
Cacng1	A	G	11: 107,704,319 (GRCm38)	F144S	probably damaging	Het
Dnm3	T	A	1: 162,355,432 (GRCm38)	T105S	probably damaging	Het
Efcab6	T	A	15: 83,879,448 (GRCm38)	I1228F	probably damaging	Het
Erc2	A	G	14: 27,776,980 (GRCm38)	D271G	probably damaging	Het
Fat3	T	C	9: 15,997,137 (GRCm38)	Y2523C	probably damaging	Het
Fhl4	A	G	10: 85,098,171 (GRCm38)	F249L	probably damaging	Het
Gm17782	T	C	17: 36,162,066 (GRCm38)		probably benign	Het
Gm4787	A	G	12: 81,378,728 (GRCm38)	Y219H	probably damaging	Het
Hk1	A	G	10: 62,292,359 (GRCm38)	L328P	probably benign	Het
Hspa12a	T	A	19: 58,809,551 (GRCm38)	Y245F	probably benign	Het
Kbtbd12	T	C	6: 88,618,389 (GRCm38)	Y153C	probably damaging	Het
Kcnd2	A	T	6: 21,726,195 (GRCm38)	R562S	probably benign	Het
Lct	T	C	1: 128,308,251 (GRCm38)	S340G	probably benign	Het
Maats1	T	A	16: 38,333,778 (GRCm38)	D135V	possibly damaging	Het
Mettl25	C	A	10: 105,826,324 (GRCm38)	G262W	probably damaging	Het
Mindy3	G	A	2: 12,364,483 (GRCm38)	Q142*	probably null	Het
Olfr1045	A	T	2: 86,198,019 (GRCm38)	H244Q	probably damaging	Het
Optn	T	C	2: 5,035,022 (GRCm38)	E318G	probably damaging	Het
Pan2	T	C	10: 128,312,899 (GRCm38)	S443P	probably benign	Het
Parva	A	G	7: 112,576,439 (GRCm38)	D259G	probably damaging	Het
Pkhd1l1	T	A	15: 44,584,873 (GRCm38)	L3816Q	probably damaging	Het
Polq	T	C	16: 37,060,375 (GRCm38)	F967S	probably benign	Het
Prdm16	T	C	4: 154,340,877 (GRCm38)	N817S	probably damaging	Het
Ptprt	C	A	2: 161,607,452 (GRCm38)		probably benign	Het
Rbbp8nl	T	A	2: 180,281,443 (GRCm38)	S154C	probably damaging	Het
Ror2	C	T	13: 53,110,728 (GRCm38)	S764N	probably damaging	Het
Slit1	T	C	19: 41,651,683 (GRCm38)	I169V	probably damaging	Het
Smyd4	G	T	11: 75,390,064 (GRCm38)		probably benign	Het
Tial1	A	G	7: 128,443,883 (GRCm38)	Y326H	probably benign	Het
Tmem198b	A	G	10: 128,802,451 (GRCm38)	L81P	probably damaging	Het
Tmem94	T	A	11: 115,796,401 (GRCm38)	C1115*	probably null	Het
Wdr38	A	T	2: 38,998,412 (GRCm38)	N7I	probably damaging	Het
Zfp106	A	T	2: 120,545,914 (GRCm38)		probably null	Het
Zfp119b	T	C	17: 55,939,793 (GRCm38)	E99G	probably damaging	Het
Zfp462	T	A	4: 55,012,986 (GRCm38)	C503S	probably damaging	Het
Zfyve19	G	A	2: 119,212,015 (GRCm38)		probably null	Het
Zxdc	G	T	6: 90,382,370 (GRCm38)	K661N	probably damaging	Het

Other mutations in Tns3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Tns3	APN	11	8,451,066 (GRCm38)	missense	probably benign	0.42
IGL00822:Tns3	APN	11	8,443,976 (GRCm38)	missense	probably damaging	0.99
IGL01075:Tns3	APN	11	8,478,399 (GRCm38)	missense	probably benign	0.45
IGL01286:Tns3	APN	11	8,492,617 (GRCm38)	missense	probably benign	0.01
IGL01680:Tns3	APN	11	8,548,937 (GRCm38)	missense	probably damaging	1.00
IGL01687:Tns3	APN	11	8,492,798 (GRCm38)	missense	probably damaging	1.00
IGL01734:Tns3	APN	11	8,519,192 (GRCm38)	splice site	probably benign
IGL01844:Tns3	APN	11	8,437,177 (GRCm38)	missense	possibly damaging	0.58
IGL01984:Tns3	APN	11	8,548,992 (GRCm38)	nonsense	probably null
IGL02137:Tns3	APN	11	8,492,578 (GRCm38)	missense	possibly damaging	0.93
IGL02273:Tns3	APN	11	8,434,531 (GRCm38)	missense	probably damaging	1.00
IGL02697:Tns3	APN	11	8,492,346 (GRCm38)	missense	probably benign	0.00
IGL02829:Tns3	APN	11	8,519,564 (GRCm38)	missense	probably damaging	1.00
ANU74:Tns3	UTSW	11	8,492,149 (GRCm38)	missense	probably benign	0.38
R0020:Tns3	UTSW	11	8,545,227 (GRCm38)	critical splice donor site	probably null
R0064:Tns3	UTSW	11	8,435,856 (GRCm38)	nonsense	probably null
R0064:Tns3	UTSW	11	8,435,856 (GRCm38)	nonsense	probably null
R0370:Tns3	UTSW	11	8,445,730 (GRCm38)	missense	possibly damaging	0.80
R0388:Tns3	UTSW	11	8,445,703 (GRCm38)	missense	probably benign	0.07
R0410:Tns3	UTSW	11	8,435,852 (GRCm38)	missense	probably benign	0.02
R0496:Tns3	UTSW	11	8,547,262 (GRCm38)	splice site	probably benign
R0562:Tns3	UTSW	11	8,493,262 (GRCm38)	missense	possibly damaging	0.93
R0626:Tns3	UTSW	11	8,493,121 (GRCm38)	missense	probably benign	0.04
R0736:Tns3	UTSW	11	8,519,474 (GRCm38)	missense	possibly damaging	0.94
R0893:Tns3	UTSW	11	8,493,302 (GRCm38)	missense	probably damaging	1.00
R1367:Tns3	UTSW	11	8,448,704 (GRCm38)	missense	probably benign	0.01
R1386:Tns3	UTSW	11	8,518,261 (GRCm38)	missense	probably benign	0.02
R1975:Tns3	UTSW	11	8,435,738 (GRCm38)	missense	probably benign	0.04
R2205:Tns3	UTSW	11	8,531,719 (GRCm38)	missense	probably damaging	1.00
R2319:Tns3	UTSW	11	8,541,200 (GRCm38)	missense	probably damaging	1.00
R2830:Tns3	UTSW	11	8,435,870 (GRCm38)	missense	probably damaging	1.00
R3720:Tns3	UTSW	11	8,492,999 (GRCm38)	missense	probably damaging	1.00
R3765:Tns3	UTSW	11	8,451,133 (GRCm38)	missense	probably benign	0.00
R3817:Tns3	UTSW	11	8,434,619 (GRCm38)	missense	probably damaging	1.00
R4058:Tns3	UTSW	11	8,492,275 (GRCm38)	missense	probably damaging	1.00
R4599:Tns3	UTSW	11	8,531,747 (GRCm38)	missense	probably damaging	1.00
R4631:Tns3	UTSW	11	8,451,119 (GRCm38)	missense	probably benign	0.30
R4731:Tns3	UTSW	11	8,450,986 (GRCm38)	missense	probably benign	0.28
R4732:Tns3	UTSW	11	8,450,986 (GRCm38)	missense	probably benign	0.28
R4733:Tns3	UTSW	11	8,450,986 (GRCm38)	missense	probably benign	0.28
R5472:Tns3	UTSW	11	8,451,092 (GRCm38)	missense	probably benign
R5749:Tns3	UTSW	11	8,451,177 (GRCm38)	missense	probably benign	0.01
R5807:Tns3	UTSW	11	8,493,211 (GRCm38)	missense	probably damaging	1.00
R5844:Tns3	UTSW	11	8,434,580 (GRCm38)	missense	probably damaging	1.00
R5942:Tns3	UTSW	11	8,435,860 (GRCm38)	missense	probably damaging	1.00
R5982:Tns3	UTSW	11	8,492,245 (GRCm38)	missense	probably damaging	0.99
R6025:Tns3	UTSW	11	8,492,578 (GRCm38)	missense	possibly damaging	0.93
R6266:Tns3	UTSW	11	8,492,987 (GRCm38)	missense	probably damaging	1.00
R6322:Tns3	UTSW	11	8,492,147 (GRCm38)	missense	probably benign	0.01
R6536:Tns3	UTSW	11	8,434,531 (GRCm38)	missense	probably damaging	1.00
R6577:Tns3	UTSW	11	8,549,058 (GRCm38)	missense	probably damaging	1.00
R6577:Tns3	UTSW	11	8,549,057 (GRCm38)	missense	probably damaging	1.00
R6864:Tns3	UTSW	11	8,493,196 (GRCm38)	missense	probably damaging	1.00
R6897:Tns3	UTSW	11	8,531,743 (GRCm38)	missense	probably damaging	1.00
R7108:Tns3	UTSW	11	8,437,251 (GRCm38)	missense	probably benign	0.00
R7443:Tns3	UTSW	11	8,451,442 (GRCm38)	missense	probably benign	0.01
R7459:Tns3	UTSW	11	8,492,793 (GRCm38)	missense	probably benign	0.16
R7474:Tns3	UTSW	11	8,530,894 (GRCm38)	missense	probably damaging	1.00
R7576:Tns3	UTSW	11	8,541,192 (GRCm38)	missense	possibly damaging	0.78
R7979:Tns3	UTSW	11	8,492,701 (GRCm38)	missense	probably benign	0.01
R8055:Tns3	UTSW	11	8,545,343 (GRCm38)	missense	probably damaging	1.00
R8057:Tns3	UTSW	11	8,492,773 (GRCm38)	missense	probably benign
R8077:Tns3	UTSW	11	8,445,667 (GRCm38)	missense	probably damaging	1.00
R8518:Tns3	UTSW	11	8,492,971 (GRCm38)	missense	probably damaging	0.96
R8523:Tns3	UTSW	11	8,448,779 (GRCm38)	missense	probably damaging	1.00
R8790:Tns3	UTSW	11	8,518,273 (GRCm38)	missense	probably damaging	0.99
R9228:Tns3	UTSW	11	8,450,094 (GRCm38)	missense	probably damaging	1.00
R9374:Tns3	UTSW	11	8,492,606 (GRCm38)	missense	probably damaging	1.00
R9476:Tns3	UTSW	11	8,445,702 (GRCm38)	missense	probably damaging	0.99
R9510:Tns3	UTSW	11	8,445,702 (GRCm38)	missense	probably damaging	0.99
R9594:Tns3	UTSW	11	8,451,142 (GRCm38)	missense	possibly damaging	0.79
R9595:Tns3	UTSW	11	8,451,142 (GRCm38)	missense	possibly damaging	0.79
R9596:Tns3	UTSW	11	8,451,142 (GRCm38)	missense	possibly damaging	0.79
R9624:Tns3	UTSW	11	8,451,142 (GRCm38)	missense	possibly damaging	0.79
R9629:Tns3	UTSW	11	8,451,142 (GRCm38)	missense	possibly damaging	0.79
T0975:Tns3	UTSW	11	8,451,146 (GRCm38)	missense	probably benign	0.00
T0975:Tns3	UTSW	11	8,549,100 (GRCm38)	start gained	probably benign
T0975:Tns3	UTSW	11	8,479,518 (GRCm38)	missense	probably benign
X0005:Tns3	UTSW	11	8,479,518 (GRCm38)	missense	probably benign
X0005:Tns3	UTSW	11	8,451,224 (GRCm38)	missense	probably benign	0.00
Z1177:Tns3	UTSW	11	8,451,014 (GRCm38)	nonsense	probably null

Posted On

2015-04-16