Incidental Mutation 'IGL02624:Tex21'
ID300999
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tex21
Ensembl Gene ENSMUSG00000021056
Gene Nametestis expressed gene 21
Synonyms4931412D23Rik, tsec-2, 4931406F04Rik, 4931421K24Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.098) question?
Stock #IGL02624
Quality Score
Status
Chromosome12
Chromosomal Location76198686-76246746 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 76214624 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Valine at position 250 (D250V)
Ref Sequence ENSEMBL: ENSMUSP00000151515 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021453] [ENSMUST00000218426]
Predicted Effect probably damaging
Transcript: ENSMUST00000021453
AA Change: D250V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000021453
Gene: ENSMUSG00000021056
AA Change: D250V

DomainStartEndE-ValueType
coiled coil region 83 190 N/A INTRINSIC
coiled coil region 308 356 N/A INTRINSIC
coiled coil region 409 447 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000218426
AA Change: D250V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220068
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930004D18Rik A G 2: 18,027,193 V38A unknown Het
Armc8 T C 9: 99,527,069 probably benign Het
Brk1 T G 6: 113,604,844 I22M possibly damaging Het
Cd3g A G 9: 44,974,161 probably null Het
Cep192 T C 18: 67,880,795 V2422A probably benign Het
Ces2g T C 8: 104,964,748 V172A probably damaging Het
Clcn2 G T 16: 20,703,348 S830R probably damaging Het
Cyp26b1 T C 6: 84,584,339 S114G probably benign Het
Dnali1 T C 4: 125,058,998 Q244R probably benign Het
Entpd1 A T 19: 40,726,058 K204* probably null Het
Gm5070 A G 3: 95,410,908 noncoding transcript Het
Gpsm2 G T 3: 108,682,033 D596E probably benign Het
Hectd1 C T 12: 51,762,450 A1743T possibly damaging Het
Kcnq5 T G 1: 21,402,430 L845F probably benign Het
Lmx1a G T 1: 167,844,623 probably benign Het
Lrp1 A T 10: 127,572,422 I1795N probably damaging Het
Lsp1 C T 7: 142,490,551 probably benign Het
Mcm6 C T 1: 128,349,448 A213T possibly damaging Het
Mylk G T 16: 34,929,896 V1202L probably benign Het
Myo5b T C 18: 74,714,939 Y1083H probably damaging Het
Ncoa5 T A 2: 165,013,061 D47V probably damaging Het
Npat C T 9: 53,566,810 T954I probably damaging Het
Olfr1367 A G 13: 21,347,512 T195A probably benign Het
Olfr491 A T 7: 108,316,923 T10S probably benign Het
Pfkm T C 15: 98,126,395 I428T probably benign Het
Rai1 T C 11: 60,188,743 F1211S probably damaging Het
Reln T C 5: 22,103,357 E338G probably benign Het
Tbx18 T C 9: 87,727,406 Y192C probably damaging Het
Tpo A G 12: 30,100,414 V489A probably benign Het
Tspo T C 15: 83,571,415 M1T probably null Het
Wdr38 A T 2: 38,998,412 N7I probably damaging Het
Wnk2 C T 13: 49,102,802 G281D probably damaging Het
Zfhx2 T C 14: 55,066,628 T1300A probably benign Het
Other mutations in Tex21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00472:Tex21 APN 12 76206797 missense probably damaging 1.00
IGL00923:Tex21 APN 12 76245111 missense probably damaging 1.00
IGL01062:Tex21 APN 12 76198944 missense probably benign 0.03
IGL01063:Tex21 APN 12 76198818 missense probably benign 0.34
IGL03349:Tex21 APN 12 76221591 missense probably benign 0.14
IGL03387:Tex21 APN 12 76198920 missense probably damaging 1.00
IGL03412:Tex21 APN 12 76245006 critical splice donor site probably null
R0189:Tex21 UTSW 12 76239533 missense probably benign 0.13
R0730:Tex21 UTSW 12 76204166 missense probably benign 0.25
R1521:Tex21 UTSW 12 76204270 missense probably benign 0.38
R1572:Tex21 UTSW 12 76206891 missense probably benign 0.03
R1700:Tex21 UTSW 12 76221672 missense probably damaging 0.99
R1941:Tex21 UTSW 12 76221684 missense possibly damaging 0.68
R4654:Tex21 UTSW 12 76217086 missense probably benign 0.32
R4943:Tex21 UTSW 12 76221700 missense probably damaging 1.00
R6175:Tex21 UTSW 12 76198933 missense probably benign 0.00
R6262:Tex21 UTSW 12 76212532 missense probably damaging 0.99
R6738:Tex21 UTSW 12 76239509 missense probably benign 0.12
R6759:Tex21 UTSW 12 76204312 critical splice acceptor site probably null
R6890:Tex21 UTSW 12 76239455 critical splice donor site probably null
Z1176:Tex21 UTSW 12 76204120 missense probably damaging 1.00
Posted On2015-04-16