Incidental Mutation 'IGL02624:Cd3g'
ID301011
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cd3g
Ensembl Gene ENSMUSG00000002033
Gene NameCD3 antigen, gamma polypeptide
SynonymsT3g, Ctg3, Ctg-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #IGL02624
Quality Score
Status
Chromosome9
Chromosomal Location44969572-44980431 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 44974161 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002101] [ENSMUST00000002101] [ENSMUST00000160886] [ENSMUST00000160886]
Predicted Effect probably null
Transcript: ENSMUST00000002101
SMART Domains Protein: ENSMUSP00000002101
Gene: ENSMUSG00000002033

DomainStartEndE-ValueType
IGc2 37 94 3.51e-8 SMART
transmembrane domain 115 137 N/A INTRINSIC
ITAM 157 177 2.06e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000002101
SMART Domains Protein: ENSMUSP00000002101
Gene: ENSMUSG00000002033

DomainStartEndE-ValueType
IGc2 37 94 3.51e-8 SMART
transmembrane domain 115 137 N/A INTRINSIC
ITAM 157 177 2.06e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159019
Predicted Effect probably null
Transcript: ENSMUST00000160886
SMART Domains Protein: ENSMUSP00000125151
Gene: ENSMUSG00000002033

DomainStartEndE-ValueType
IGc2 29 86 3.51e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000160886
SMART Domains Protein: ENSMUSP00000125151
Gene: ENSMUSG00000002033

DomainStartEndE-ValueType
IGc2 29 86 3.51e-8 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased thymocyte number and T cell response. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930004D18Rik A G 2: 18,027,193 V38A unknown Het
Armc8 T C 9: 99,527,069 probably benign Het
Brk1 T G 6: 113,604,844 I22M possibly damaging Het
Cep192 T C 18: 67,880,795 V2422A probably benign Het
Ces2g T C 8: 104,964,748 V172A probably damaging Het
Clcn2 G T 16: 20,703,348 S830R probably damaging Het
Cyp26b1 T C 6: 84,584,339 S114G probably benign Het
Dnali1 T C 4: 125,058,998 Q244R probably benign Het
Entpd1 A T 19: 40,726,058 K204* probably null Het
Gm5070 A G 3: 95,410,908 noncoding transcript Het
Gpsm2 G T 3: 108,682,033 D596E probably benign Het
Hectd1 C T 12: 51,762,450 A1743T possibly damaging Het
Kcnq5 T G 1: 21,402,430 L845F probably benign Het
Lmx1a G T 1: 167,844,623 probably benign Het
Lrp1 A T 10: 127,572,422 I1795N probably damaging Het
Lsp1 C T 7: 142,490,551 probably benign Het
Mcm6 C T 1: 128,349,448 A213T possibly damaging Het
Mylk G T 16: 34,929,896 V1202L probably benign Het
Myo5b T C 18: 74,714,939 Y1083H probably damaging Het
Ncoa5 T A 2: 165,013,061 D47V probably damaging Het
Npat C T 9: 53,566,810 T954I probably damaging Het
Olfr1367 A G 13: 21,347,512 T195A probably benign Het
Olfr491 A T 7: 108,316,923 T10S probably benign Het
Pfkm T C 15: 98,126,395 I428T probably benign Het
Rai1 T C 11: 60,188,743 F1211S probably damaging Het
Reln T C 5: 22,103,357 E338G probably benign Het
Tbx18 T C 9: 87,727,406 Y192C probably damaging Het
Tex21 T A 12: 76,214,624 D250V probably damaging Het
Tpo A G 12: 30,100,414 V489A probably benign Het
Tspo T C 15: 83,571,415 M1T probably null Het
Wdr38 A T 2: 38,998,412 N7I probably damaging Het
Wnk2 C T 13: 49,102,802 G281D probably damaging Het
Zfhx2 T C 14: 55,066,628 T1300A probably benign Het
Other mutations in Cd3g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01881:Cd3g APN 9 44971268 missense probably damaging 1.00
IGL02750:Cd3g APN 9 44971310 unclassified probably benign
IGL03097:Cd3g UTSW 9 44970763 missense probably damaging 1.00
R1711:Cd3g UTSW 9 44974342 missense probably damaging 1.00
R2076:Cd3g UTSW 9 44974297 missense probably damaging 1.00
R3614:Cd3g UTSW 9 44980289 missense probably benign 0.39
R4514:Cd3g UTSW 9 44973584 missense possibly damaging 0.93
R5732:Cd3g UTSW 9 44973631 missense possibly damaging 0.89
R6520:Cd3g UTSW 9 44971315 splice site probably null
R7447:Cd3g UTSW 9 44973559 missense probably damaging 1.00
R7776:Cd3g UTSW 9 44974161 critical splice donor site probably null
Posted On2015-04-16