Incidental Mutation 'IGL02625:Wdr38'
ID 301027
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr38
Ensembl Gene ENSMUSG00000035295
Gene Name WD repeat domain 38
Synonyms 1700123D08Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # IGL02625
Quality Score
Status
Chromosome 2
Chromosomal Location 38888287-38891600 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 38888424 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 7 (N7I)
Ref Sequence ENSEMBL: ENSMUSP00000108493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039535] [ENSMUST00000080861] [ENSMUST00000112872]
AlphaFold Q9D994
Predicted Effect probably damaging
Transcript: ENSMUST00000039535
AA Change: N7I

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000043834
Gene: ENSMUSG00000035295
AA Change: N7I

DomainStartEndE-ValueType
WD40 15 54 9.67e-7 SMART
WD40 57 96 9.22e-13 SMART
WD40 99 138 4.4e-10 SMART
WD40 141 180 1.21e-7 SMART
WD40 186 224 9.97e-9 SMART
WD40 227 266 4.34e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000080861
SMART Domains Protein: ENSMUSP00000079672
Gene: ENSMUSG00000062997

DomainStartEndE-ValueType
Pfam:Ribosomal_L29 7 63 2.7e-22 PFAM
low complexity region 95 108 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000112872
AA Change: N7I

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000108493
Gene: ENSMUSG00000035295
AA Change: N7I

DomainStartEndE-ValueType
WD40 15 54 9.67e-7 SMART
WD40 57 96 9.22e-13 SMART
WD40 99 138 4.4e-10 SMART
WD40 141 180 1.21e-7 SMART
WD40 186 224 9.97e-9 SMART
WD40 227 266 4.34e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124062
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141133
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152441
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alg6 T A 4: 99,634,584 (GRCm39) C109S probably damaging Het
Arhgdia C A 11: 120,471,039 (GRCm39) E53D probably benign Het
Ccr4 A C 9: 114,321,401 (GRCm39) C221W probably damaging Het
Ces2a G A 8: 105,466,910 (GRCm39) probably null Het
Chpf2 G T 5: 24,796,709 (GRCm39) E552* probably null Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Dnmt1 C T 9: 20,838,442 (GRCm39) R207H probably benign Het
Dock2 A G 11: 34,451,168 (GRCm39) probably null Het
Esr1 A T 10: 4,951,346 (GRCm39) T575S probably benign Het
Fancc A G 13: 63,545,965 (GRCm39) C93R probably damaging Het
Foxj3 A T 4: 119,482,114 (GRCm39) R523W unknown Het
Fryl C T 5: 73,227,220 (GRCm39) probably benign Het
Fsip2 A C 2: 82,779,836 (GRCm39) H194P probably benign Het
Gaa G A 11: 119,165,559 (GRCm39) V350I probably damaging Het
Gpn3 T A 5: 122,519,257 (GRCm39) I152N probably damaging Het
H2-M10.3 T A 17: 36,678,417 (GRCm39) H136L probably benign Het
H4c16 C T 6: 136,781,335 (GRCm39) probably benign Het
Hspg2 A G 4: 137,239,953 (GRCm39) D507G probably damaging Het
Jcad A G 18: 4,674,422 (GRCm39) E728G probably benign Het
Kat14 G A 2: 144,244,365 (GRCm39) R406H possibly damaging Het
Kcnma1 G T 14: 23,413,900 (GRCm39) D863E probably damaging Het
Lrp1 A G 10: 127,410,355 (GRCm39) Y1464H probably damaging Het
Map4 T C 9: 109,893,485 (GRCm39) S584P probably damaging Het
Nlrp4f G A 13: 65,347,085 (GRCm39) L58F probably damaging Het
Nlrp6 A G 7: 140,503,413 (GRCm39) I506M probably benign Het
Nudt17 G A 3: 96,613,780 (GRCm39) R266W probably damaging Het
Or4a47 A G 2: 89,665,740 (GRCm39) L183P probably damaging Het
Or4a69 A G 2: 89,313,018 (GRCm39) S154P probably damaging Het
Or52h9 A G 7: 104,202,780 (GRCm39) Y218C probably damaging Het
Plcb4 A G 2: 135,803,714 (GRCm39) E529G probably benign Het
Prss32 A T 17: 24,075,210 (GRCm39) I187F possibly damaging Het
Prss55 A T 14: 64,316,818 (GRCm39) I108K probably damaging Het
Rcl1 A G 19: 29,095,741 (GRCm39) M109V probably benign Het
Rho A T 6: 115,912,158 (GRCm39) M207L possibly damaging Het
Slc12a1 A G 2: 125,012,611 (GRCm39) D291G probably damaging Het
Slco2b1 A C 7: 99,309,330 (GRCm39) probably null Het
Stx11 T A 10: 12,817,661 (GRCm39) D21V possibly damaging Het
Svep1 T A 4: 58,115,807 (GRCm39) Y962F possibly damaging Het
Tbx5 G T 5: 119,974,972 (GRCm39) probably benign Het
Tcf12 C A 9: 71,830,039 (GRCm39) G141W probably damaging Het
Tmtc2 A G 10: 105,206,407 (GRCm39) M296T probably damaging Het
Trim13 T A 14: 61,842,999 (GRCm39) S339T probably benign Het
Ugt1a7c A G 1: 88,023,239 (GRCm39) K133E possibly damaging Het
Usp40 A G 1: 87,877,739 (GRCm39) V1050A probably benign Het
Vmn2r86 T G 10: 130,288,781 (GRCm39) N240T probably damaging Het
Wdr36 T C 18: 32,992,314 (GRCm39) V617A possibly damaging Het
Wdr6 T C 9: 108,452,704 (GRCm39) Y393C probably damaging Het
Zfp619 A T 7: 39,183,609 (GRCm39) probably benign Het
Other mutations in Wdr38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01549:Wdr38 APN 2 38,890,730 (GRCm39) missense probably damaging 1.00
IGL02019:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
IGL02020:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
IGL02137:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
IGL02138:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
IGL02172:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
IGL02178:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
IGL02422:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
IGL02423:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
IGL02525:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
IGL02526:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
IGL02621:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
IGL02623:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
IGL02624:Wdr38 APN 2 38,888,424 (GRCm39) missense probably damaging 0.97
PIT4696001:Wdr38 UTSW 2 38,889,984 (GRCm39) critical splice acceptor site probably null
R1473:Wdr38 UTSW 2 38,890,991 (GRCm39) missense probably benign 0.03
R1794:Wdr38 UTSW 2 38,890,741 (GRCm39) missense probably damaging 1.00
R3964:Wdr38 UTSW 2 38,889,362 (GRCm39) missense probably damaging 1.00
R6005:Wdr38 UTSW 2 38,891,333 (GRCm39) missense possibly damaging 0.57
R6432:Wdr38 UTSW 2 38,890,723 (GRCm39) missense probably damaging 1.00
R6513:Wdr38 UTSW 2 38,889,970 (GRCm39) splice site probably null
R7266:Wdr38 UTSW 2 38,890,276 (GRCm39) missense probably damaging 1.00
R7454:Wdr38 UTSW 2 38,888,352 (GRCm39) start gained probably benign
R7834:Wdr38 UTSW 2 38,890,196 (GRCm39) missense possibly damaging 0.84
R8333:Wdr38 UTSW 2 38,889,361 (GRCm39) missense probably damaging 1.00
R9542:Wdr38 UTSW 2 38,890,210 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16