Incidental Mutation 'IGL02629:Serpina3g'
ID 301203
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Serpina3g
Ensembl Gene ENSMUSG00000041481
Gene Name serine (or cysteine) peptidase inhibitor, clade A, member 3G
Synonyms Spi2A, alpha-1 antiproteinase,, Spi2-1, Spi2/eb.1, alpha-1 antiproteinase, 2A2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # IGL02629
Quality Score
Status
Chromosome 12
Chromosomal Location 104202504-104208198 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 104207437 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 200 (D200G)
Ref Sequence ENSEMBL: ENSMUSP00000041250 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043315] [ENSMUST00000170628] [ENSMUST00000171916]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000043315
AA Change: D200G

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000041250
Gene: ENSMUSG00000041481
AA Change: D200G

DomainStartEndE-ValueType
SERPIN 1 215 1.09e-43 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000170628
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171065
Predicted Effect probably benign
Transcript: ENSMUST00000171916
SMART Domains Protein: ENSMUSP00000129633
Gene: ENSMUSG00000041481

DomainStartEndE-ValueType
Pfam:Serpin 1 101 1.3e-31 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired memory T cell homeostatic proliferation, decreased CD8+ T cells and antigen-specific CD8+ T cells after LCMV infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik T C 10: 100,445,006 (GRCm39) probably benign Het
Aadacl3 A G 4: 144,190,199 (GRCm39) I34T possibly damaging Het
Acan T A 7: 78,761,727 (GRCm39) I1979N possibly damaging Het
Ankrd27 A G 7: 35,325,121 (GRCm39) D701G probably benign Het
Arhgap31 C T 16: 38,429,526 (GRCm39) G450S probably benign Het
Braf T C 6: 39,665,233 (GRCm39) E45G possibly damaging Het
Btnl6 C T 17: 34,733,442 (GRCm39) V178M probably damaging Het
Capg A T 6: 72,532,737 (GRCm39) Q67L probably benign Het
Carmil3 A G 14: 55,736,525 (GRCm39) N663S probably damaging Het
Casz1 T A 4: 149,028,848 (GRCm39) S1098T probably benign Het
Cd55b A T 1: 130,347,535 (GRCm39) probably benign Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Cenpf A G 1: 189,384,531 (GRCm39) L2583P probably damaging Het
Clec4a1 A C 6: 122,909,106 (GRCm39) probably null Het
Corin T C 5: 72,490,016 (GRCm39) N653S probably damaging Het
Dhx36 T C 3: 62,414,155 (GRCm39) E69G probably benign Het
Dpy19l1 C A 9: 24,350,009 (GRCm39) probably benign Het
Fam184a T C 10: 53,574,907 (GRCm39) N234S possibly damaging Het
Foxg1 A G 12: 49,432,331 (GRCm39) S355G probably benign Het
Fsd1l T C 4: 53,686,417 (GRCm39) S277P probably damaging Het
Hadh T A 3: 131,029,284 (GRCm39) D245V probably damaging Het
Jag2 G A 12: 112,878,134 (GRCm39) probably benign Het
Klhl18 A T 9: 110,259,006 (GRCm39) probably benign Het
Lmx1a G T 1: 167,672,192 (GRCm39) probably benign Het
Mcoln2 A G 3: 145,875,799 (GRCm39) Y89C probably benign Het
Mug1 A T 6: 121,817,024 (GRCm39) Y31F possibly damaging Het
Ndufb5 A G 3: 32,791,348 (GRCm39) T32A probably benign Het
Nub1 C T 5: 24,908,462 (GRCm39) H404Y possibly damaging Het
Nudt6 A G 3: 37,459,320 (GRCm39) Y222H probably benign Het
Or4x6 A T 2: 89,949,201 (GRCm39) L247* probably null Het
Pla2g4c A T 7: 13,069,302 (GRCm39) R159* probably null Het
Pnpla7 A G 2: 24,940,957 (GRCm39) D1103G probably damaging Het
Pof1b T G X: 111,554,934 (GRCm39) probably benign Het
Prrg2 C T 7: 44,706,166 (GRCm39) probably null Het
Rab3gap1 A G 1: 127,837,600 (GRCm39) T221A probably benign Het
Rfx7 A G 9: 72,526,541 (GRCm39) N1244D probably damaging Het
Rnf123 G A 9: 107,945,501 (GRCm39) R390* probably null Het
Rnf123 A T 9: 107,947,988 (GRCm39) probably benign Het
Rnf44 T G 13: 54,830,875 (GRCm39) Q207P possibly damaging Het
Slc5a4a T A 10: 75,983,413 (GRCm39) S17T unknown Het
Smc4 G T 3: 68,933,206 (GRCm39) C609F probably damaging Het
Sync T C 4: 129,187,744 (GRCm39) F259L probably damaging Het
Tas2r113 T C 6: 132,870,299 (GRCm39) L109P probably damaging Het
Tjp2 C A 19: 24,099,743 (GRCm39) probably benign Het
Tmem30a C A 9: 79,683,531 (GRCm39) probably benign Het
Unc80 T C 1: 66,522,476 (GRCm39) V226A possibly damaging Het
Upk2 A T 9: 44,365,436 (GRCm39) L44Q probably damaging Het
Usp42 T C 5: 143,708,909 (GRCm39) Y203C possibly damaging Het
Vmn1r28 A T 6: 58,242,801 (GRCm39) I215F probably benign Het
Zswim2 A G 2: 83,755,553 (GRCm39) V116A possibly damaging Het
Other mutations in Serpina3g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02663:Serpina3g APN 12 104,205,399 (GRCm39) missense possibly damaging 0.94
BB008:Serpina3g UTSW 12 104,205,428 (GRCm39) missense probably benign 0.00
BB018:Serpina3g UTSW 12 104,205,428 (GRCm39) missense probably benign 0.00
R0047:Serpina3g UTSW 12 104,206,543 (GRCm39) missense possibly damaging 0.69
R0525:Serpina3g UTSW 12 104,204,598 (GRCm39) missense probably damaging 1.00
R0702:Serpina3g UTSW 12 104,207,512 (GRCm39) missense probably damaging 0.96
R1163:Serpina3g UTSW 12 104,205,551 (GRCm39) missense possibly damaging 0.84
R1595:Serpina3g UTSW 12 104,205,531 (GRCm39) missense probably benign 0.16
R1908:Serpina3g UTSW 12 104,207,536 (GRCm39) missense probably damaging 0.96
R2089:Serpina3g UTSW 12 104,205,417 (GRCm39) missense probably damaging 1.00
R2091:Serpina3g UTSW 12 104,205,417 (GRCm39) missense probably damaging 1.00
R2091:Serpina3g UTSW 12 104,205,417 (GRCm39) missense probably damaging 1.00
R2403:Serpina3g UTSW 12 104,207,421 (GRCm39) missense probably damaging 1.00
R4165:Serpina3g UTSW 12 104,206,546 (GRCm39) missense probably benign 0.00
R4466:Serpina3g UTSW 12 104,204,182 (GRCm39) splice site probably benign
R4669:Serpina3g UTSW 12 104,205,479 (GRCm39) missense probably damaging 1.00
R4735:Serpina3g UTSW 12 104,205,372 (GRCm39) missense probably damaging 1.00
R5423:Serpina3g UTSW 12 104,204,253 (GRCm39) utr 5 prime probably benign
R5552:Serpina3g UTSW 12 104,206,595 (GRCm39) missense probably damaging 0.96
R5605:Serpina3g UTSW 12 104,207,299 (GRCm39) missense probably damaging 1.00
R6384:Serpina3g UTSW 12 104,206,655 (GRCm39) missense probably null 0.34
R6446:Serpina3g UTSW 12 104,205,341 (GRCm39) missense probably damaging 1.00
R7100:Serpina3g UTSW 12 104,204,570 (GRCm39) start gained probably benign
R7869:Serpina3g UTSW 12 104,206,510 (GRCm39) missense probably benign 0.05
R7878:Serpina3g UTSW 12 104,204,361 (GRCm39) start gained probably benign
R7931:Serpina3g UTSW 12 104,205,428 (GRCm39) missense probably benign 0.00
R8260:Serpina3g UTSW 12 104,205,362 (GRCm39) missense probably benign 0.01
R8839:Serpina3g UTSW 12 104,204,038 (GRCm39) intron probably benign
R9420:Serpina3g UTSW 12 104,206,518 (GRCm39) missense probably benign 0.01
Posted On 2015-04-16