Incidental Mutation 'IGL02630:Ivns1abp'
ID 301271
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ivns1abp
Ensembl Gene ENSMUSG00000023150
Gene Name influenza virus NS1A binding protein
Synonyms 1190004M08Rik, 1700126I16Rik, Nd1-L, HSPC068, NS1-BP, ND1, Nd1-S, NS-1
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.405) question?
Stock # IGL02630
Quality Score
Status
Chromosome 1
Chromosomal Location 151220228-151240173 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 151235386 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 218 (R218H)
Ref Sequence ENSEMBL: ENSMUSP00000095150 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023918] [ENSMUST00000097543] [ENSMUST00000111887] [ENSMUST00000186745] [ENSMUST00000190872]
AlphaFold Q920Q8
Predicted Effect possibly damaging
Transcript: ENSMUST00000023918
AA Change: R260H

PolyPhen 2 Score 0.543 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000023918
Gene: ENSMUSG00000023150
AA Change: R260H

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
BACK 134 233 3.39e-8 SMART
low complexity region 325 338 N/A INTRINSIC
Kelch 369 415 4.78e-15 SMART
Kelch 416 463 2.16e-13 SMART
Kelch 464 512 2.15e-8 SMART
Kelch 513 559 1.58e-15 SMART
Kelch 560 606 1.61e-12 SMART
Kelch 607 641 1.85e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000097543
AA Change: R218H

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000095150
Gene: ENSMUSG00000023150
AA Change: R218H

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
Pfam:BACK 134 189 3.3e-8 PFAM
low complexity region 283 296 N/A INTRINSIC
Kelch 327 373 4.78e-15 SMART
Kelch 374 421 2.16e-13 SMART
Kelch 422 470 2.15e-8 SMART
Kelch 471 517 1.58e-15 SMART
Kelch 518 564 1.61e-12 SMART
Kelch 565 599 1.85e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000111887
SMART Domains Protein: ENSMUSP00000107518
Gene: ENSMUSG00000023150

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
BACK 134 219 7.04e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000186745
SMART Domains Protein: ENSMUSP00000140708
Gene: ENSMUSG00000023150

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
BACK 134 219 7.04e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000190872
SMART Domains Protein: ENSMUSP00000140332
Gene: ENSMUSG00000023150

DomainStartEndE-ValueType
Kelch 22 68 5.3e-18 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak T A 19: 8,989,441 (GRCm39) V3575E probably damaging Het
Arfgef3 G A 10: 18,537,140 (GRCm39) probably benign Het
Arhgap23 A G 11: 97,345,123 (GRCm39) T631A probably benign Het
Chka T A 19: 3,942,112 (GRCm39) H355Q possibly damaging Het
Ctsj C T 13: 61,149,214 (GRCm39) A277T probably damaging Het
Ddx49 T C 8: 70,753,668 (GRCm39) D67G probably damaging Het
Dennd4b T C 3: 90,180,284 (GRCm39) S716P probably benign Het
Enpp5 G T 17: 44,393,766 (GRCm39) D321Y probably damaging Het
Espl1 A G 15: 102,205,253 (GRCm39) E17G probably benign Het
Fam161b G A 12: 84,400,688 (GRCm39) P428L probably benign Het
Fbxw7 T C 3: 84,872,586 (GRCm39) L256S probably damaging Het
Fgfr2 G T 7: 129,830,525 (GRCm39) probably null Het
Foxred2 C T 15: 77,831,362 (GRCm39) V484I probably benign Het
Gm4744 T A 6: 40,927,403 (GRCm39) probably benign Het
H3c1 C T 13: 23,946,231 (GRCm39) V36M probably benign Het
Hipk2 T C 6: 38,795,456 (GRCm39) N271S possibly damaging Het
Ifna1 A G 4: 88,768,496 (GRCm39) D58G possibly damaging Het
Igkv4-80 A T 6: 68,993,680 (GRCm39) Y70* probably null Het
Kng1 A T 16: 22,898,595 (GRCm39) probably benign Het
Lars1 T C 18: 42,390,234 (GRCm39) D11G probably damaging Het
Lgals12 T C 19: 7,578,607 (GRCm39) probably benign Het
Lpar4 T A X: 105,974,817 (GRCm39) F334I probably benign Het
Muc5b G A 7: 141,416,968 (GRCm39) G3305S probably benign Het
Nalcn T C 14: 123,555,291 (GRCm39) D864G probably benign Het
Ndor1 T C 2: 25,145,299 (GRCm39) E22G probably damaging Het
Nt5c2 T A 19: 46,912,749 (GRCm39) M69L probably benign Het
Or52ab4 A C 7: 102,987,636 (GRCm39) Y125S probably damaging Het
Or8k22 T C 2: 86,163,212 (GRCm39) I163V probably benign Het
Pde12 A T 14: 26,387,552 (GRCm39) H455Q probably damaging Het
Pdia6 A G 12: 17,324,422 (GRCm39) H91R probably benign Het
Pdk4 A T 6: 5,491,671 (GRCm39) I179K possibly damaging Het
Prl2c1 T C 13: 28,041,480 (GRCm39) probably benign Het
Rasgrf2 C T 13: 92,267,900 (GRCm39) E35K probably damaging Het
Rnf123 G A 9: 107,945,501 (GRCm39) R390* probably null Het
Sash1 T A 10: 8,620,299 (GRCm39) M454L probably benign Het
Secisbp2 C A 13: 51,832,942 (GRCm39) T608K possibly damaging Het
Slco1a7 T C 6: 141,668,836 (GRCm39) Y532C probably damaging Het
Slmap A G 14: 26,143,586 (GRCm39) V750A possibly damaging Het
Spaca6 T A 17: 18,051,351 (GRCm39) L9Q probably damaging Het
Sycp1 T C 3: 102,786,080 (GRCm39) probably benign Het
Sycp2 A T 2: 178,043,712 (GRCm39) D131E probably damaging Het
Tc2n A T 12: 101,659,404 (GRCm39) D176E probably damaging Het
Thoc7 T C 14: 13,953,154 (GRCm38) I83V probably damaging Het
Trank1 T C 9: 111,202,143 (GRCm39) V1590A possibly damaging Het
Tyrp1 T C 4: 80,758,994 (GRCm39) V289A possibly damaging Het
Ube2dnl1 T A X: 113,815,483 (GRCm39) C119* probably null Het
Vmn1r191 T A 13: 22,363,431 (GRCm39) I108F possibly damaging Het
Zfp710 T A 7: 79,731,789 (GRCm39) I322N probably damaging Het
Other mutations in Ivns1abp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00225:Ivns1abp APN 1 151,226,863 (GRCm39) splice site probably null
IGL01616:Ivns1abp APN 1 151,237,294 (GRCm39) missense possibly damaging 0.69
IGL02061:Ivns1abp APN 1 151,227,324 (GRCm39) missense probably damaging 0.97
H8562:Ivns1abp UTSW 1 151,230,446 (GRCm39) missense probably damaging 0.98
PIT1430001:Ivns1abp UTSW 1 151,237,356 (GRCm39) missense probably damaging 1.00
R0107:Ivns1abp UTSW 1 151,237,321 (GRCm39) missense probably damaging 0.99
R0609:Ivns1abp UTSW 1 151,235,896 (GRCm39) missense probably benign 0.02
R1104:Ivns1abp UTSW 1 151,235,860 (GRCm39) missense probably benign 0.42
R1463:Ivns1abp UTSW 1 151,237,291 (GRCm39) missense probably benign 0.05
R1512:Ivns1abp UTSW 1 151,236,688 (GRCm39) missense probably benign 0.02
R1512:Ivns1abp UTSW 1 151,236,687 (GRCm39) missense possibly damaging 0.87
R1521:Ivns1abp UTSW 1 151,227,309 (GRCm39) missense probably damaging 1.00
R1550:Ivns1abp UTSW 1 151,237,242 (GRCm39) missense probably damaging 1.00
R2047:Ivns1abp UTSW 1 151,227,382 (GRCm39) missense possibly damaging 0.83
R2435:Ivns1abp UTSW 1 151,239,061 (GRCm39) missense probably benign 0.04
R4471:Ivns1abp UTSW 1 151,236,990 (GRCm39) missense probably benign 0.29
R5011:Ivns1abp UTSW 1 151,238,953 (GRCm39) missense possibly damaging 0.76
R5667:Ivns1abp UTSW 1 151,229,760 (GRCm39) missense probably benign 0.01
R5671:Ivns1abp UTSW 1 151,229,760 (GRCm39) missense probably benign 0.01
R6505:Ivns1abp UTSW 1 151,236,744 (GRCm39) missense probably benign 0.00
R8357:Ivns1abp UTSW 1 151,229,761 (GRCm39) missense probably damaging 1.00
R8457:Ivns1abp UTSW 1 151,229,761 (GRCm39) missense probably damaging 1.00
Z1176:Ivns1abp UTSW 1 151,226,784 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16