Incidental Mutation 'IGL02630:Ivns1abp'
ID |
301271 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Ivns1abp
|
Ensembl Gene |
ENSMUSG00000023150 |
Gene Name |
influenza virus NS1A binding protein |
Synonyms |
1190004M08Rik, 1700126I16Rik, Nd1-L, HSPC068, NS1-BP, ND1, Nd1-S, NS-1 |
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.405)
|
Stock # |
IGL02630
|
Quality Score |
|
Status
|
|
Chromosome |
1 |
Chromosomal Location |
151220228-151240173 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 151235386 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Histidine
at position 218
(R218H)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000095150
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023918]
[ENSMUST00000097543]
[ENSMUST00000111887]
[ENSMUST00000186745]
[ENSMUST00000190872]
|
AlphaFold |
Q920Q8 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000023918
AA Change: R260H
PolyPhen 2
Score 0.543 (Sensitivity: 0.88; Specificity: 0.91)
|
SMART Domains |
Protein: ENSMUSP00000023918 Gene: ENSMUSG00000023150 AA Change: R260H
Domain | Start | End | E-Value | Type |
BTB
|
32 |
129 |
1.89e-25 |
SMART |
BACK
|
134 |
233 |
3.39e-8 |
SMART |
low complexity region
|
325 |
338 |
N/A |
INTRINSIC |
Kelch
|
369 |
415 |
4.78e-15 |
SMART |
Kelch
|
416 |
463 |
2.16e-13 |
SMART |
Kelch
|
464 |
512 |
2.15e-8 |
SMART |
Kelch
|
513 |
559 |
1.58e-15 |
SMART |
Kelch
|
560 |
606 |
1.61e-12 |
SMART |
Kelch
|
607 |
641 |
1.85e-1 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000097543
AA Change: R218H
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000095150 Gene: ENSMUSG00000023150 AA Change: R218H
Domain | Start | End | E-Value | Type |
BTB
|
32 |
129 |
1.89e-25 |
SMART |
Pfam:BACK
|
134 |
189 |
3.3e-8 |
PFAM |
low complexity region
|
283 |
296 |
N/A |
INTRINSIC |
Kelch
|
327 |
373 |
4.78e-15 |
SMART |
Kelch
|
374 |
421 |
2.16e-13 |
SMART |
Kelch
|
422 |
470 |
2.15e-8 |
SMART |
Kelch
|
471 |
517 |
1.58e-15 |
SMART |
Kelch
|
518 |
564 |
1.61e-12 |
SMART |
Kelch
|
565 |
599 |
1.85e-1 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000111887
|
SMART Domains |
Protein: ENSMUSP00000107518 Gene: ENSMUSG00000023150
Domain | Start | End | E-Value | Type |
BTB
|
32 |
129 |
1.89e-25 |
SMART |
BACK
|
134 |
219 |
7.04e-6 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000186745
|
SMART Domains |
Protein: ENSMUSP00000140708 Gene: ENSMUSG00000023150
Domain | Start | End | E-Value | Type |
BTB
|
32 |
129 |
1.89e-25 |
SMART |
BACK
|
134 |
219 |
7.04e-6 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000190872
|
SMART Domains |
Protein: ENSMUSP00000140332 Gene: ENSMUSG00000023150
Domain | Start | End | E-Value | Type |
Kelch
|
22 |
68 |
5.3e-18 |
SMART |
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 48 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ahnak |
T |
A |
19: 8,989,441 (GRCm39) |
V3575E |
probably damaging |
Het |
Arfgef3 |
G |
A |
10: 18,537,140 (GRCm39) |
|
probably benign |
Het |
Arhgap23 |
A |
G |
11: 97,345,123 (GRCm39) |
T631A |
probably benign |
Het |
Chka |
T |
A |
19: 3,942,112 (GRCm39) |
H355Q |
possibly damaging |
Het |
Ctsj |
C |
T |
13: 61,149,214 (GRCm39) |
A277T |
probably damaging |
Het |
Ddx49 |
T |
C |
8: 70,753,668 (GRCm39) |
D67G |
probably damaging |
Het |
Dennd4b |
T |
C |
3: 90,180,284 (GRCm39) |
S716P |
probably benign |
Het |
Enpp5 |
G |
T |
17: 44,393,766 (GRCm39) |
D321Y |
probably damaging |
Het |
Espl1 |
A |
G |
15: 102,205,253 (GRCm39) |
E17G |
probably benign |
Het |
Fam161b |
G |
A |
12: 84,400,688 (GRCm39) |
P428L |
probably benign |
Het |
Fbxw7 |
T |
C |
3: 84,872,586 (GRCm39) |
L256S |
probably damaging |
Het |
Fgfr2 |
G |
T |
7: 129,830,525 (GRCm39) |
|
probably null |
Het |
Foxred2 |
C |
T |
15: 77,831,362 (GRCm39) |
V484I |
probably benign |
Het |
Gm4744 |
T |
A |
6: 40,927,403 (GRCm39) |
|
probably benign |
Het |
H3c1 |
C |
T |
13: 23,946,231 (GRCm39) |
V36M |
probably benign |
Het |
Hipk2 |
T |
C |
6: 38,795,456 (GRCm39) |
N271S |
possibly damaging |
Het |
Ifna1 |
A |
G |
4: 88,768,496 (GRCm39) |
D58G |
possibly damaging |
Het |
Igkv4-80 |
A |
T |
6: 68,993,680 (GRCm39) |
Y70* |
probably null |
Het |
Kng1 |
A |
T |
16: 22,898,595 (GRCm39) |
|
probably benign |
Het |
Lars1 |
T |
C |
18: 42,390,234 (GRCm39) |
D11G |
probably damaging |
Het |
Lgals12 |
T |
C |
19: 7,578,607 (GRCm39) |
|
probably benign |
Het |
Lpar4 |
T |
A |
X: 105,974,817 (GRCm39) |
F334I |
probably benign |
Het |
Muc5b |
G |
A |
7: 141,416,968 (GRCm39) |
G3305S |
probably benign |
Het |
Nalcn |
T |
C |
14: 123,555,291 (GRCm39) |
D864G |
probably benign |
Het |
Ndor1 |
T |
C |
2: 25,145,299 (GRCm39) |
E22G |
probably damaging |
Het |
Nt5c2 |
T |
A |
19: 46,912,749 (GRCm39) |
M69L |
probably benign |
Het |
Or52ab4 |
A |
C |
7: 102,987,636 (GRCm39) |
Y125S |
probably damaging |
Het |
Or8k22 |
T |
C |
2: 86,163,212 (GRCm39) |
I163V |
probably benign |
Het |
Pde12 |
A |
T |
14: 26,387,552 (GRCm39) |
H455Q |
probably damaging |
Het |
Pdia6 |
A |
G |
12: 17,324,422 (GRCm39) |
H91R |
probably benign |
Het |
Pdk4 |
A |
T |
6: 5,491,671 (GRCm39) |
I179K |
possibly damaging |
Het |
Prl2c1 |
T |
C |
13: 28,041,480 (GRCm39) |
|
probably benign |
Het |
Rasgrf2 |
C |
T |
13: 92,267,900 (GRCm39) |
E35K |
probably damaging |
Het |
Rnf123 |
G |
A |
9: 107,945,501 (GRCm39) |
R390* |
probably null |
Het |
Sash1 |
T |
A |
10: 8,620,299 (GRCm39) |
M454L |
probably benign |
Het |
Secisbp2 |
C |
A |
13: 51,832,942 (GRCm39) |
T608K |
possibly damaging |
Het |
Slco1a7 |
T |
C |
6: 141,668,836 (GRCm39) |
Y532C |
probably damaging |
Het |
Slmap |
A |
G |
14: 26,143,586 (GRCm39) |
V750A |
possibly damaging |
Het |
Spaca6 |
T |
A |
17: 18,051,351 (GRCm39) |
L9Q |
probably damaging |
Het |
Sycp1 |
T |
C |
3: 102,786,080 (GRCm39) |
|
probably benign |
Het |
Sycp2 |
A |
T |
2: 178,043,712 (GRCm39) |
D131E |
probably damaging |
Het |
Tc2n |
A |
T |
12: 101,659,404 (GRCm39) |
D176E |
probably damaging |
Het |
Thoc7 |
T |
C |
14: 13,953,154 (GRCm38) |
I83V |
probably damaging |
Het |
Trank1 |
T |
C |
9: 111,202,143 (GRCm39) |
V1590A |
possibly damaging |
Het |
Tyrp1 |
T |
C |
4: 80,758,994 (GRCm39) |
V289A |
possibly damaging |
Het |
Ube2dnl1 |
T |
A |
X: 113,815,483 (GRCm39) |
C119* |
probably null |
Het |
Vmn1r191 |
T |
A |
13: 22,363,431 (GRCm39) |
I108F |
possibly damaging |
Het |
Zfp710 |
T |
A |
7: 79,731,789 (GRCm39) |
I322N |
probably damaging |
Het |
|
Other mutations in Ivns1abp |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00225:Ivns1abp
|
APN |
1 |
151,226,863 (GRCm39) |
splice site |
probably null |
|
IGL01616:Ivns1abp
|
APN |
1 |
151,237,294 (GRCm39) |
missense |
possibly damaging |
0.69 |
IGL02061:Ivns1abp
|
APN |
1 |
151,227,324 (GRCm39) |
missense |
probably damaging |
0.97 |
H8562:Ivns1abp
|
UTSW |
1 |
151,230,446 (GRCm39) |
missense |
probably damaging |
0.98 |
PIT1430001:Ivns1abp
|
UTSW |
1 |
151,237,356 (GRCm39) |
missense |
probably damaging |
1.00 |
R0107:Ivns1abp
|
UTSW |
1 |
151,237,321 (GRCm39) |
missense |
probably damaging |
0.99 |
R0609:Ivns1abp
|
UTSW |
1 |
151,235,896 (GRCm39) |
missense |
probably benign |
0.02 |
R1104:Ivns1abp
|
UTSW |
1 |
151,235,860 (GRCm39) |
missense |
probably benign |
0.42 |
R1463:Ivns1abp
|
UTSW |
1 |
151,237,291 (GRCm39) |
missense |
probably benign |
0.05 |
R1512:Ivns1abp
|
UTSW |
1 |
151,236,688 (GRCm39) |
missense |
probably benign |
0.02 |
R1512:Ivns1abp
|
UTSW |
1 |
151,236,687 (GRCm39) |
missense |
possibly damaging |
0.87 |
R1521:Ivns1abp
|
UTSW |
1 |
151,227,309 (GRCm39) |
missense |
probably damaging |
1.00 |
R1550:Ivns1abp
|
UTSW |
1 |
151,237,242 (GRCm39) |
missense |
probably damaging |
1.00 |
R2047:Ivns1abp
|
UTSW |
1 |
151,227,382 (GRCm39) |
missense |
possibly damaging |
0.83 |
R2435:Ivns1abp
|
UTSW |
1 |
151,239,061 (GRCm39) |
missense |
probably benign |
0.04 |
R4471:Ivns1abp
|
UTSW |
1 |
151,236,990 (GRCm39) |
missense |
probably benign |
0.29 |
R5011:Ivns1abp
|
UTSW |
1 |
151,238,953 (GRCm39) |
missense |
possibly damaging |
0.76 |
R5667:Ivns1abp
|
UTSW |
1 |
151,229,760 (GRCm39) |
missense |
probably benign |
0.01 |
R5671:Ivns1abp
|
UTSW |
1 |
151,229,760 (GRCm39) |
missense |
probably benign |
0.01 |
R6505:Ivns1abp
|
UTSW |
1 |
151,236,744 (GRCm39) |
missense |
probably benign |
0.00 |
R8357:Ivns1abp
|
UTSW |
1 |
151,229,761 (GRCm39) |
missense |
probably damaging |
1.00 |
R8457:Ivns1abp
|
UTSW |
1 |
151,229,761 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Ivns1abp
|
UTSW |
1 |
151,226,784 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Posted On |
2015-04-16 |