Incidental Mutation 'IGL02630:Ivns1abp'
ID301271
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ivns1abp
Ensembl Gene ENSMUSG00000023150
Gene Nameinfluenza virus NS1A binding protein
SynonymsNS-1, Nd1-L, Nd1-S, 1700126I16Rik, 1190004M08Rik, ND1, HSPC068, NS1-BP
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.395) question?
Stock #IGL02630
Quality Score
Status
Chromosome1
Chromosomal Location151344477-151364422 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 151359635 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Histidine at position 218 (R218H)
Ref Sequence ENSEMBL: ENSMUSP00000095150 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023918] [ENSMUST00000097543] [ENSMUST00000111887] [ENSMUST00000186745] [ENSMUST00000190872]
Predicted Effect possibly damaging
Transcript: ENSMUST00000023918
AA Change: R260H

PolyPhen 2 Score 0.543 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000023918
Gene: ENSMUSG00000023150
AA Change: R260H

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
BACK 134 233 3.39e-8 SMART
low complexity region 325 338 N/A INTRINSIC
Kelch 369 415 4.78e-15 SMART
Kelch 416 463 2.16e-13 SMART
Kelch 464 512 2.15e-8 SMART
Kelch 513 559 1.58e-15 SMART
Kelch 560 606 1.61e-12 SMART
Kelch 607 641 1.85e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000097543
AA Change: R218H

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000095150
Gene: ENSMUSG00000023150
AA Change: R218H

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
Pfam:BACK 134 189 3.3e-8 PFAM
low complexity region 283 296 N/A INTRINSIC
Kelch 327 373 4.78e-15 SMART
Kelch 374 421 2.16e-13 SMART
Kelch 422 470 2.15e-8 SMART
Kelch 471 517 1.58e-15 SMART
Kelch 518 564 1.61e-12 SMART
Kelch 565 599 1.85e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000111887
SMART Domains Protein: ENSMUSP00000107518
Gene: ENSMUSG00000023150

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
BACK 134 219 7.04e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000186745
SMART Domains Protein: ENSMUSP00000140708
Gene: ENSMUSG00000023150

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
BACK 134 219 7.04e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000190872
SMART Domains Protein: ENSMUSP00000140332
Gene: ENSMUSG00000023150

DomainStartEndE-ValueType
Kelch 22 68 5.3e-18 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak T A 19: 9,012,077 V3575E probably damaging Het
Arfgef3 G A 10: 18,661,392 probably benign Het
Arhgap23 A G 11: 97,454,297 T631A probably benign Het
Chka T A 19: 3,892,112 H355Q possibly damaging Het
Ctsj C T 13: 61,001,400 A277T probably damaging Het
Ddx49 T C 8: 70,301,018 D67G probably damaging Het
Dennd4b T C 3: 90,272,977 S716P probably benign Het
Enpp5 G T 17: 44,082,875 D321Y probably damaging Het
Espl1 A G 15: 102,296,818 E17G probably benign Het
Fam161b G A 12: 84,353,914 P428L probably benign Het
Fbxw7 T C 3: 84,965,279 L256S probably damaging Het
Fgfr2 G T 7: 130,228,795 probably null Het
Foxred2 C T 15: 77,947,162 V484I probably benign Het
Gm4744 T A 6: 40,950,469 probably benign Het
Gm5724 T C 6: 141,723,110 Y532C probably damaging Het
Hipk2 T C 6: 38,818,521 N271S possibly damaging Het
Hist1h3a C T 13: 23,762,248 V36M probably benign Het
Ifna1 A G 4: 88,850,259 D58G possibly damaging Het
Igkv4-80 A T 6: 69,016,696 Y70* probably null Het
Kng1 A T 16: 23,079,845 probably benign Het
Lars T C 18: 42,257,169 D11G probably damaging Het
Lgals12 T C 19: 7,601,242 probably benign Het
Lpar4 T A X: 106,931,211 F334I probably benign Het
Muc5b G A 7: 141,863,231 G3305S probably benign Het
Nalcn T C 14: 123,317,879 D864G probably benign Het
Ndor1 T C 2: 25,255,287 E22G probably damaging Het
Nt5c2 T A 19: 46,924,310 M69L probably benign Het
Olfr1054 T C 2: 86,332,868 I163V probably benign Het
Olfr599 A C 7: 103,338,429 Y125S probably damaging Het
Pde12 A T 14: 26,666,397 H455Q probably damaging Het
Pdia6 A G 12: 17,274,421 H91R probably benign Het
Pdk4 A T 6: 5,491,671 I179K possibly damaging Het
Prl2c1 T C 13: 27,857,497 probably benign Het
Rasgrf2 C T 13: 92,131,392 E35K probably damaging Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Sash1 T A 10: 8,744,535 M454L probably benign Het
Secisbp2 C A 13: 51,678,906 T608K possibly damaging Het
Slmap A G 14: 26,422,431 V750A possibly damaging Het
Spaca6 T A 17: 17,831,089 L9Q probably damaging Het
Sycp1 T C 3: 102,878,764 probably benign Het
Sycp2 A T 2: 178,401,919 D131E probably damaging Het
Tc2n A T 12: 101,693,145 D176E probably damaging Het
Thoc7 T C 14: 13,953,154 I83V probably damaging Het
Trank1 T C 9: 111,373,075 V1590A possibly damaging Het
Tyrp1 T C 4: 80,840,757 V289A possibly damaging Het
Ube2dnl1 T A X: 114,905,786 C119* probably null Het
Vmn1r191 T A 13: 22,179,261 I108F possibly damaging Het
Zfp710 T A 7: 80,082,041 I322N probably damaging Het
Other mutations in Ivns1abp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00225:Ivns1abp APN 1 151351112 splice site probably null
IGL01616:Ivns1abp APN 1 151361543 missense possibly damaging 0.69
IGL02061:Ivns1abp APN 1 151351573 missense probably damaging 0.97
H8562:Ivns1abp UTSW 1 151354695 missense probably damaging 0.98
PIT1430001:Ivns1abp UTSW 1 151361605 missense probably damaging 1.00
R0107:Ivns1abp UTSW 1 151361570 missense probably damaging 0.99
R0609:Ivns1abp UTSW 1 151360145 missense probably benign 0.02
R1104:Ivns1abp UTSW 1 151360109 missense probably benign 0.42
R1463:Ivns1abp UTSW 1 151361540 missense probably benign 0.05
R1512:Ivns1abp UTSW 1 151360936 missense possibly damaging 0.87
R1512:Ivns1abp UTSW 1 151360937 missense probably benign 0.02
R1521:Ivns1abp UTSW 1 151351558 missense probably damaging 1.00
R1550:Ivns1abp UTSW 1 151361491 missense probably damaging 1.00
R2047:Ivns1abp UTSW 1 151351631 missense possibly damaging 0.83
R2435:Ivns1abp UTSW 1 151363310 missense probably benign 0.04
R4471:Ivns1abp UTSW 1 151361239 missense probably benign 0.29
R5011:Ivns1abp UTSW 1 151363202 missense possibly damaging 0.76
R5667:Ivns1abp UTSW 1 151354009 missense probably benign 0.01
R5671:Ivns1abp UTSW 1 151354009 missense probably benign 0.01
R6505:Ivns1abp UTSW 1 151360993 missense probably benign 0.00
Z1176:Ivns1abp UTSW 1 151351033 missense probably damaging 0.99
Posted On2015-04-16