Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02630:Fam161b'

301272

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fam161b

Ensembl Gene

ENSMUSG00000021234

Gene Name

family with sequence similarity 161, member B

Synonyms

9830169C18Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL02630

Quality Score

Status

Chromosome

Chromosomal Location

84392083-84408607 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 84400688 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 428 (P428L)

Ref Sequence

ENSEMBL: ENSMUSP00000070407 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021659] [ENSMUST00000065536]

AlphaFold

Q8CB59

Predicted Effect

probably benign
Transcript: ENSMUST00000021659
AA Change: P428L

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000021659
Gene: ENSMUSG00000021234
AA Change: P428L

Domain	Start	End	E-Value	Type
low complexity region	57	65	N/A	INTRINSIC
low complexity region	93	107	N/A	INTRINSIC
Pfam:UPF0564	168	535	5.3e-100	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000065536
AA Change: P428L

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000070407
Gene: ENSMUSG00000021234
AA Change: P428L

Domain	Start	End	E-Value	Type
low complexity region	57	65	N/A	INTRINSIC
low complexity region	93	107	N/A	INTRINSIC
Pfam:UPF0564	168	535	8.3e-112	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126752

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133230

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak	T	A	19: 8,989,441 (GRCm39)	V3575E	probably damaging	Het
Arfgef3	G	A	10: 18,537,140 (GRCm39)		probably benign	Het
Arhgap23	A	G	11: 97,345,123 (GRCm39)	T631A	probably benign	Het
Chka	T	A	19: 3,942,112 (GRCm39)	H355Q	possibly damaging	Het
Ctsj	C	T	13: 61,149,214 (GRCm39)	A277T	probably damaging	Het
Ddx49	T	C	8: 70,753,668 (GRCm39)	D67G	probably damaging	Het
Dennd4b	T	C	3: 90,180,284 (GRCm39)	S716P	probably benign	Het
Enpp5	G	T	17: 44,393,766 (GRCm39)	D321Y	probably damaging	Het
Espl1	A	G	15: 102,205,253 (GRCm39)	E17G	probably benign	Het
Fbxw7	T	C	3: 84,872,586 (GRCm39)	L256S	probably damaging	Het
Fgfr2	G	T	7: 129,830,525 (GRCm39)		probably null	Het
Foxred2	C	T	15: 77,831,362 (GRCm39)	V484I	probably benign	Het
Gm4744	T	A	6: 40,927,403 (GRCm39)		probably benign	Het
H3c1	C	T	13: 23,946,231 (GRCm39)	V36M	probably benign	Het
Hipk2	T	C	6: 38,795,456 (GRCm39)	N271S	possibly damaging	Het
Ifna1	A	G	4: 88,768,496 (GRCm39)	D58G	possibly damaging	Het
Igkv4-80	A	T	6: 68,993,680 (GRCm39)	Y70*	probably null	Het
Ivns1abp	G	A	1: 151,235,386 (GRCm39)	R218H	probably damaging	Het
Kng1	A	T	16: 22,898,595 (GRCm39)		probably benign	Het
Lars1	T	C	18: 42,390,234 (GRCm39)	D11G	probably damaging	Het
Lgals12	T	C	19: 7,578,607 (GRCm39)		probably benign	Het
Lpar4	T	A	X: 105,974,817 (GRCm39)	F334I	probably benign	Het
Muc5b	G	A	7: 141,416,968 (GRCm39)	G3305S	probably benign	Het
Nalcn	T	C	14: 123,555,291 (GRCm39)	D864G	probably benign	Het
Ndor1	T	C	2: 25,145,299 (GRCm39)	E22G	probably damaging	Het
Nt5c2	T	A	19: 46,912,749 (GRCm39)	M69L	probably benign	Het
Or52ab4	A	C	7: 102,987,636 (GRCm39)	Y125S	probably damaging	Het
Or8k22	T	C	2: 86,163,212 (GRCm39)	I163V	probably benign	Het
Pde12	A	T	14: 26,387,552 (GRCm39)	H455Q	probably damaging	Het
Pdia6	A	G	12: 17,324,422 (GRCm39)	H91R	probably benign	Het
Pdk4	A	T	6: 5,491,671 (GRCm39)	I179K	possibly damaging	Het
Prl2c1	T	C	13: 28,041,480 (GRCm39)		probably benign	Het
Rasgrf2	C	T	13: 92,267,900 (GRCm39)	E35K	probably damaging	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Sash1	T	A	10: 8,620,299 (GRCm39)	M454L	probably benign	Het
Secisbp2	C	A	13: 51,832,942 (GRCm39)	T608K	possibly damaging	Het
Slco1a7	T	C	6: 141,668,836 (GRCm39)	Y532C	probably damaging	Het
Slmap	A	G	14: 26,143,586 (GRCm39)	V750A	possibly damaging	Het
Spaca6	T	A	17: 18,051,351 (GRCm39)	L9Q	probably damaging	Het
Sycp1	T	C	3: 102,786,080 (GRCm39)		probably benign	Het
Sycp2	A	T	2: 178,043,712 (GRCm39)	D131E	probably damaging	Het
Tc2n	A	T	12: 101,659,404 (GRCm39)	D176E	probably damaging	Het
Thoc7	T	C	14: 13,953,154 (GRCm38)	I83V	probably damaging	Het
Trank1	T	C	9: 111,202,143 (GRCm39)	V1590A	possibly damaging	Het
Tyrp1	T	C	4: 80,758,994 (GRCm39)	V289A	possibly damaging	Het
Ube2dnl1	T	A	X: 113,815,483 (GRCm39)	C119*	probably null	Het
Vmn1r191	T	A	13: 22,363,431 (GRCm39)	I108F	possibly damaging	Het
Zfp710	T	A	7: 79,731,789 (GRCm39)	I322N	probably damaging	Het

Other mutations in Fam161b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00540:Fam161b	APN	12	84,408,525 (GRCm39)	unclassified	probably benign
IGL00900:Fam161b	APN	12	84,402,743 (GRCm39)	missense	probably benign	0.05
IGL00905:Fam161b	APN	12	84,404,459 (GRCm39)	missense	probably benign	0.00
IGL01123:Fam161b	APN	12	84,404,438 (GRCm39)	missense	probably benign	0.00
IGL02156:Fam161b	APN	12	84,401,527 (GRCm39)	missense	probably benign	0.00
IGL02670:Fam161b	APN	12	84,404,368 (GRCm39)	missense	probably benign	0.00
IGL03160:Fam161b	APN	12	84,400,599 (GRCm39)	missense	probably benign	0.05
R0560:Fam161b	UTSW	12	84,404,492 (GRCm39)	missense	probably damaging	0.96
R0569:Fam161b	UTSW	12	84,395,413 (GRCm39)	missense	probably damaging	1.00
R1834:Fam161b	UTSW	12	84,395,552 (GRCm39)	splice site	probably benign
R2070:Fam161b	UTSW	12	84,403,202 (GRCm39)	missense	probably benign	0.00
R3784:Fam161b	UTSW	12	84,408,464 (GRCm39)	critical splice donor site	probably null
R3786:Fam161b	UTSW	12	84,408,464 (GRCm39)	critical splice donor site	probably null
R4697:Fam161b	UTSW	12	84,395,332 (GRCm39)	unclassified	probably benign
R5247:Fam161b	UTSW	12	84,404,524 (GRCm39)	missense	probably damaging	1.00
R5390:Fam161b	UTSW	12	84,395,408 (GRCm39)	missense	probably damaging	0.99
R5668:Fam161b	UTSW	12	84,403,124 (GRCm39)	missense	probably damaging	0.96
R6891:Fam161b	UTSW	12	84,401,554 (GRCm39)	missense	probably damaging	1.00
R7189:Fam161b	UTSW	12	84,395,420 (GRCm39)	missense	probably damaging	1.00
R7410:Fam161b	UTSW	12	84,404,575 (GRCm39)	missense	probably benign	0.04
R7514:Fam161b	UTSW	12	84,404,512 (GRCm39)	missense	possibly damaging	0.76
R8035:Fam161b	UTSW	12	84,395,430 (GRCm39)	missense	probably damaging	1.00
R8219:Fam161b	UTSW	12	84,393,648 (GRCm39)	missense	probably benign	0.00
R8428:Fam161b	UTSW	12	84,404,369 (GRCm39)	missense	probably benign	0.00
R8921:Fam161b	UTSW	12	84,395,056 (GRCm39)	missense	probably benign	0.02
R9638:Fam161b	UTSW	12	84,403,187 (GRCm39)	missense	probably benign	0.00
X0019:Fam161b	UTSW	12	84,401,747 (GRCm39)	missense	probably benign	0.30
Z1176:Fam161b	UTSW	12	84,402,827 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16