Incidental Mutation 'R0361:Zfp457'
ID 30133
Institutional Source Beutler Lab
Gene Symbol Zfp457
Ensembl Gene ENSMUSG00000055341
Gene Name zinc finger protein 457
Synonyms Rslcan-6
MMRRC Submission 038567-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R0361 (G1)
Quality Score 182
Status Not validated
Chromosome 13
Chromosomal Location 67440514-67454476 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 67440710 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 622 (F622L)
Ref Sequence ENSEMBL: ENSMUSP00000053879 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049705] [ENSMUST00000224325]
AlphaFold L7N1X4
Predicted Effect probably damaging
Transcript: ENSMUST00000049705
AA Change: F622L

PolyPhen 2 Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000053879
Gene: ENSMUSG00000055341
AA Change: F622L

DomainStartEndE-ValueType
KRAB 5 65 1.55e-29 SMART
ZnF_C2H2 81 103 2.75e-3 SMART
ZnF_C2H2 109 131 1.1e-2 SMART
ZnF_C2H2 165 187 3.63e-3 SMART
ZnF_C2H2 193 215 2.4e-3 SMART
ZnF_C2H2 221 243 1.12e-3 SMART
ZnF_C2H2 249 271 6.32e-3 SMART
ZnF_C2H2 277 299 6.32e-3 SMART
ZnF_C2H2 305 327 3.52e-1 SMART
ZnF_C2H2 333 355 3.89e-3 SMART
ZnF_C2H2 361 383 7.26e-3 SMART
ZnF_C2H2 389 411 1.2e-3 SMART
ZnF_C2H2 417 439 7.67e-2 SMART
ZnF_C2H2 445 467 1.05e1 SMART
ZnF_C2H2 473 495 3.11e-2 SMART
ZnF_C2H2 501 523 5.9e-3 SMART
ZnF_C2H2 529 551 9.08e-4 SMART
ZnF_C2H2 585 607 5.72e-1 SMART
transmembrane domain 624 646 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000224325
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225090
Predicted Effect probably benign
Transcript: ENSMUST00000225338
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.7%
Validation Efficiency 100% (1/1)
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik T G 3: 124,207,283 (GRCm39) T303P possibly damaging Het
1700010I14Rik G T 17: 9,211,378 (GRCm39) V176L probably benign Het
1700034J05Rik T C 6: 146,853,869 (GRCm39) T262A possibly damaging Het
Adgrl3 A T 5: 81,908,544 (GRCm39) I1165F probably damaging Het
Ankhd1 T C 18: 36,780,267 (GRCm39) I1773T probably damaging Het
Api5 A T 2: 94,253,842 (GRCm39) L287* probably null Het
Apol10b A T 15: 77,469,586 (GRCm39) M197K possibly damaging Het
Bcl2 G A 1: 106,640,424 (GRCm39) R63W probably damaging Het
Cacna1h A G 17: 25,608,396 (GRCm39) M731T probably damaging Het
Cav1 C A 6: 17,339,352 (GRCm39) R146S possibly damaging Het
Cdhr2 A T 13: 54,881,820 (GRCm39) I1118F probably damaging Het
Cdk7 A T 13: 100,848,062 (GRCm39) Y153* probably null Het
Cemip A G 7: 83,613,218 (GRCm39) I660T probably benign Het
Cfap65 A T 1: 74,964,599 (GRCm39) L518Q probably damaging Het
Cgas T A 9: 78,340,534 (GRCm39) K399N probably damaging Het
Cngb3 A G 4: 19,366,467 (GRCm39) H176R probably benign Het
Cstdc4 T C 16: 36,004,648 (GRCm39) S7P probably damaging Het
Cux1 T A 5: 136,308,351 (GRCm39) I1263F probably damaging Het
Dnajc13 A G 9: 104,044,258 (GRCm39) M1867T probably benign Het
Dock2 A G 11: 34,388,327 (GRCm39) L202P probably damaging Het
Dyrk3 A G 1: 131,057,769 (GRCm39) S100P probably benign Het
Efr3b A T 12: 4,027,923 (GRCm39) S376T probably benign Het
Eps8l2 A C 7: 140,936,112 (GRCm39) N222T probably benign Het
Ermp1 A T 19: 29,608,806 (GRCm39) Y158N probably damaging Het
Fam13a A G 6: 58,964,159 (GRCm39) V91A probably benign Het
Fat3 A G 9: 15,909,699 (GRCm39) V2101A possibly damaging Het
Fsip2 T C 2: 82,805,849 (GRCm39) S723P possibly damaging Het
Garem1 G T 18: 21,432,801 (GRCm39) C9* probably null Het
Gdpd5 A G 7: 99,107,997 (GRCm39) I530V possibly damaging Het
Gm15217 T A 14: 46,617,841 (GRCm39) probably benign Het
Gm4922 T C 10: 18,659,289 (GRCm39) T478A probably benign Het
H2-M5 A G 17: 37,298,328 (GRCm39) I329T possibly damaging Het
Ing4 G A 6: 125,024,857 (GRCm39) C200Y probably damaging Het
Kcnip1 A T 11: 33,793,177 (GRCm39) M5K probably benign Het
Kdsr T C 1: 106,675,517 (GRCm39) E102G probably damaging Het
Krt15 C T 11: 100,024,007 (GRCm39) V346M probably benign Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Lrrc55 A T 2: 85,026,589 (GRCm39) M145K probably damaging Het
Lrrtm2 A G 18: 35,345,985 (GRCm39) I439T probably benign Het
Map2k6 T C 11: 110,390,335 (GRCm39) F290L probably damaging Het
Me1 T A 9: 86,533,055 (GRCm39) I136F probably damaging Het
Mfap2 A G 4: 140,742,294 (GRCm39) D98G probably damaging Het
Mfsd13a C T 19: 46,354,943 (GRCm39) T40I probably benign Het
Mst1 T C 9: 107,962,096 (GRCm39) F696L probably damaging Het
Mta1 A G 12: 113,096,961 (GRCm39) probably null Het
Myh15 A T 16: 48,934,368 (GRCm39) N645I probably benign Het
Myo7b T A 18: 32,147,262 (GRCm39) I94F probably damaging Het
Nefh A T 11: 4,890,799 (GRCm39) S607T probably benign Het
Noa1 G A 5: 77,445,020 (GRCm39) Q600* probably null Het
Nr2f2 A G 7: 70,007,810 (GRCm39) V71A possibly damaging Het
Oas2 A T 5: 120,876,466 (GRCm39) F492L probably damaging Het
Olfm3 T A 3: 114,914,622 (GRCm39) D211E probably damaging Het
Or2y17 A T 11: 49,231,641 (GRCm39) Y94F probably benign Het
Osmr A G 15: 6,871,432 (GRCm39) probably null Het
Plagl2 A T 2: 153,073,523 (GRCm39) D459E probably benign Het
Plch2 T C 4: 155,091,168 (GRCm39) D148G possibly damaging Het
Plxnc1 C A 10: 94,700,869 (GRCm39) C605F probably damaging Het
Ppm1m T C 9: 106,075,325 (GRCm39) E108G probably damaging Het
Prr14l A C 5: 32,950,985 (GRCm39) L1936R probably damaging Het
Ralgapa1 A G 12: 55,723,354 (GRCm39) I1771T possibly damaging Het
Rhobtb2 T C 14: 70,033,357 (GRCm39) T538A probably benign Het
Rictor A G 15: 6,813,588 (GRCm39) N1025D possibly damaging Het
Sec23a T G 12: 59,037,804 (GRCm39) D324A probably damaging Het
Srgap1 A T 10: 121,883,097 (GRCm39) M1K probably null Het
Syne2 T A 12: 75,965,384 (GRCm39) F801I probably benign Het
Synrg T A 11: 83,915,163 (GRCm39) probably null Het
Tas2r140 T G 6: 40,468,232 (GRCm39) F21V probably benign Het
Tmem260 A T 14: 48,689,504 (GRCm39) T108S possibly damaging Het
Trim2 T C 3: 84,098,083 (GRCm39) Y406C probably damaging Het
Ttn T C 2: 76,673,746 (GRCm39) probably benign Het
Vmn1r53 A T 6: 90,201,064 (GRCm39) S87T possibly damaging Het
Vmn2r115 T A 17: 23,564,196 (GRCm39) Y123N probably benign Het
Vmn2r28 T A 7: 5,496,715 (GRCm39) I46F probably benign Het
Zan T C 5: 137,395,028 (GRCm39) T4381A unknown Het
Zfp994 A T 17: 22,419,091 (GRCm39) N619K probably benign Het
Zfy1 T C Y: 726,121 (GRCm39) H548R possibly damaging Het
Zmym4 A T 4: 126,804,938 (GRCm39) S441T probably benign Het
Other mutations in Zfp457
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01329:Zfp457 APN 13 67,442,330 (GRCm39) missense possibly damaging 0.46
IGL02259:Zfp457 APN 13 67,444,471 (GRCm39) missense possibly damaging 0.88
R0055:Zfp457 UTSW 13 67,442,098 (GRCm39) missense probably damaging 0.99
R0055:Zfp457 UTSW 13 67,442,098 (GRCm39) missense probably damaging 0.99
R0149:Zfp457 UTSW 13 67,440,710 (GRCm39) missense probably damaging 0.97
R0211:Zfp457 UTSW 13 67,441,211 (GRCm39) missense probably benign 0.01
R0211:Zfp457 UTSW 13 67,441,211 (GRCm39) missense probably benign 0.01
R0230:Zfp457 UTSW 13 67,442,180 (GRCm39) missense possibly damaging 0.91
R0270:Zfp457 UTSW 13 67,441,991 (GRCm39) missense probably damaging 1.00
R0561:Zfp457 UTSW 13 67,442,134 (GRCm39) missense probably damaging 1.00
R0679:Zfp457 UTSW 13 67,441,655 (GRCm39) missense probably damaging 1.00
R0826:Zfp457 UTSW 13 67,441,378 (GRCm39) missense possibly damaging 0.85
R1136:Zfp457 UTSW 13 67,441,846 (GRCm39) missense probably damaging 1.00
R1175:Zfp457 UTSW 13 67,441,748 (GRCm39) missense probably damaging 1.00
R1523:Zfp457 UTSW 13 67,441,501 (GRCm39) missense probably damaging 1.00
R1616:Zfp457 UTSW 13 67,444,375 (GRCm39) missense possibly damaging 0.95
R2348:Zfp457 UTSW 13 67,441,468 (GRCm39) missense probably benign 0.33
R4930:Zfp457 UTSW 13 67,442,164 (GRCm39) missense probably damaging 1.00
R4964:Zfp457 UTSW 13 67,441,342 (GRCm39) missense probably damaging 1.00
R4966:Zfp457 UTSW 13 67,441,342 (GRCm39) missense probably damaging 1.00
R5040:Zfp457 UTSW 13 67,440,899 (GRCm39) missense probably benign 0.03
R5129:Zfp457 UTSW 13 67,441,420 (GRCm39) missense probably benign 0.00
R5714:Zfp457 UTSW 13 67,444,490 (GRCm39) missense possibly damaging 0.85
R6017:Zfp457 UTSW 13 67,441,763 (GRCm39) missense probably damaging 1.00
R6052:Zfp457 UTSW 13 67,442,015 (GRCm39) missense probably damaging 1.00
R6132:Zfp457 UTSW 13 67,441,360 (GRCm39) nonsense probably null
R6184:Zfp457 UTSW 13 67,440,976 (GRCm39) missense possibly damaging 0.89
R6313:Zfp457 UTSW 13 67,440,746 (GRCm39) missense probably damaging 1.00
R7038:Zfp457 UTSW 13 67,441,997 (GRCm39) missense probably benign 0.00
R7170:Zfp457 UTSW 13 67,442,241 (GRCm39) nonsense probably null
R7184:Zfp457 UTSW 13 67,442,065 (GRCm39) missense possibly damaging 0.69
R7859:Zfp457 UTSW 13 67,454,445 (GRCm39) start gained probably benign
R7973:Zfp457 UTSW 13 67,441,882 (GRCm39) missense probably benign 0.20
R8308:Zfp457 UTSW 13 67,441,663 (GRCm39) missense probably benign 0.00
R8346:Zfp457 UTSW 13 67,441,862 (GRCm39) nonsense probably null
R9114:Zfp457 UTSW 13 67,442,068 (GRCm39) missense probably benign 0.16
R9205:Zfp457 UTSW 13 67,441,965 (GRCm39) missense probably benign 0.00
R9525:Zfp457 UTSW 13 67,441,492 (GRCm39) missense probably damaging 1.00
R9765:Zfp457 UTSW 13 67,440,874 (GRCm39) missense probably benign 0.10
Predicted Primers
Posted On 2013-04-24