Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02632:Serpinb9b'

301337

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Serpinb9b

Ensembl Gene

ENSMUSG00000021403

Gene Name

serine (or cysteine) peptidase inhibitor, clade B, member 9b

Synonyms

R86, ovalbumin, Spi10, 1600019A21Rik, SPI-CI

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02632

Quality Score

Status

Chromosome

Chromosomal Location

33211397-33224571 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 33223806 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 333 (S333T)

Ref Sequence

ENSEMBL: ENSMUSP00000006392 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000006392]

AlphaFold

Q9DAV6

Predicted Effect

probably benign
Transcript: ENSMUST00000006392
AA Change: S333T

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000006392
Gene: ENSMUSG00000021403
AA Change: S333T

Domain	Start	End	E-Value	Type
SERPIN	13	377	7.86e-164	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000220566

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam25	T	C	8: 41,208,237 (GRCm39)	V501A	possibly damaging	Het
Alpl	T	G	4: 137,481,217 (GRCm39)	N145T	probably damaging	Het
Aqp5	T	A	15: 99,491,216 (GRCm39)		probably benign	Het
Atp1a2	T	A	1: 172,108,181 (GRCm39)	D640V	possibly damaging	Het
Atp5po	T	C	16: 91,725,830 (GRCm39)	E49G	probably benign	Het
Card14	A	G	11: 119,229,730 (GRCm39)	D747G	probably benign	Het
Cfap47	A	T	X: 78,540,279 (GRCm39)	L553H	probably damaging	Het
Cpz	A	T	5: 35,669,155 (GRCm39)	D325E	possibly damaging	Het
Crim1	T	C	17: 78,680,103 (GRCm39)	I948T	probably benign	Het
Dpysl3	A	T	18: 43,526,090 (GRCm39)	S2T	possibly damaging	Het
Fat4	T	C	3: 39,056,913 (GRCm39)	V4203A	probably benign	Het
Gapvd1	G	A	2: 34,574,186 (GRCm39)		probably benign	Het
Gpatch2	A	G	1: 186,958,178 (GRCm39)	R155G	probably damaging	Het
Grpr	A	T	X: 162,298,090 (GRCm39)	V318E	probably damaging	Het
Hipk1	T	C	3: 103,667,861 (GRCm39)	T569A	probably benign	Het
Il3ra	G	A	14: 14,350,807 (GRCm38)		probably null	Het
Llgl2	A	G	11: 115,735,698 (GRCm39)	H98R	probably damaging	Het
Loxhd1	A	G	18: 77,493,628 (GRCm39)	D663G	probably damaging	Het
Lrrc71	T	C	3: 87,650,647 (GRCm39)	N205S	probably damaging	Het
Mamdc2	C	T	19: 23,308,340 (GRCm39)	E521K	probably benign	Het
Mapre2	A	G	18: 23,991,217 (GRCm39)	M162V	probably benign	Het
Mettl22	T	C	16: 8,302,117 (GRCm39)		probably benign	Het
Mib2	T	C	4: 155,740,036 (GRCm39)	D739G	probably damaging	Het
Mroh2b	T	C	15: 4,960,583 (GRCm39)	F772S	probably damaging	Het
Mtss1	C	T	15: 58,815,864 (GRCm39)	M565I	probably damaging	Het
Myt1l	T	G	12: 29,964,292 (GRCm39)	S1077A	unknown	Het
Nalcn	T	C	14: 123,555,265 (GRCm39)	T873A	probably benign	Het
Nwd1	T	A	8: 73,394,082 (GRCm39)	H448Q	possibly damaging	Het
Odad2	A	G	18: 7,214,727 (GRCm39)		probably benign	Het
Or14j3	T	C	17: 37,901,232 (GRCm39)	E4G	probably benign	Het
Or51m1	A	G	7: 103,578,914 (GRCm39)	I295V	possibly damaging	Het
Or5j3	T	C	2: 86,128,904 (GRCm39)	V248A	probably damaging	Het
Palld	C	T	8: 61,968,279 (GRCm39)	E1096K	probably damaging	Het
Pdcd2	A	G	17: 15,742,054 (GRCm39)	V292A	probably damaging	Het
Pde2a	A	G	7: 101,153,863 (GRCm39)	Y477C	probably damaging	Het
Pramel16	A	G	4: 143,676,507 (GRCm39)	I199T	possibly damaging	Het
Rcbtb1	T	C	14: 59,462,131 (GRCm39)	L254P	probably damaging	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Rsl1	A	C	13: 67,330,227 (GRCm39)	H225P	probably damaging	Het
Sec14l2	T	C	11: 4,061,222 (GRCm39)	I80V	probably benign	Het
Sema6a	G	T	18: 47,423,222 (GRCm39)	D261E	probably damaging	Het
Slc24a4	T	C	12: 102,200,941 (GRCm39)	V277A	probably benign	Het
Snap91	T	A	9: 86,721,575 (GRCm39)	H88L	possibly damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Tmprss15	T	A	16: 78,782,790 (GRCm39)	N758I	probably damaging	Het
Ube3b	C	T	5: 114,536,902 (GRCm39)	A300V	probably benign	Het
Vmn2r82	G	A	10: 79,192,542 (GRCm39)	V40I	probably benign	Het
Vsig4	G	T	X: 95,291,378 (GRCm39)	Q265K	probably benign	Het
Wdr91	T	C	6: 34,865,977 (GRCm39)	D525G	probably damaging	Het

Other mutations in Serpinb9b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Serpinb9b	APN	13	33,219,608 (GRCm39)	missense	probably benign	0.00
IGL00518:Serpinb9b	APN	13	33,223,553 (GRCm39)	missense	probably benign	0.17
IGL01939:Serpinb9b	APN	13	33,223,648 (GRCm39)	missense	probably damaging	0.99
IGL02472:Serpinb9b	APN	13	33,223,953 (GRCm39)	utr 3 prime	probably benign
R0255:Serpinb9b	UTSW	13	33,222,003 (GRCm39)	missense	probably benign
R0667:Serpinb9b	UTSW	13	33,216,909 (GRCm39)	nonsense	probably null
R0699:Serpinb9b	UTSW	13	33,217,549 (GRCm39)	missense	probably benign	0.00
R0703:Serpinb9b	UTSW	13	33,216,964 (GRCm39)	missense	probably benign	0.29
R1605:Serpinb9b	UTSW	13	33,222,112 (GRCm39)	critical splice donor site	probably null
R1623:Serpinb9b	UTSW	13	33,213,548 (GRCm39)	missense	possibly damaging	0.61
R1815:Serpinb9b	UTSW	13	33,223,887 (GRCm39)	missense	probably damaging	1.00
R1920:Serpinb9b	UTSW	13	33,223,531 (GRCm39)	critical splice acceptor site	probably null
R1987:Serpinb9b	UTSW	13	33,213,542 (GRCm39)	missense	probably benign	0.07
R1988:Serpinb9b	UTSW	13	33,213,542 (GRCm39)	missense	probably benign	0.07
R3035:Serpinb9b	UTSW	13	33,213,529 (GRCm39)	missense	possibly damaging	0.81
R3683:Serpinb9b	UTSW	13	33,213,581 (GRCm39)	missense	probably damaging	0.98
R3758:Serpinb9b	UTSW	13	33,219,571 (GRCm39)	missense	probably damaging	1.00
R4677:Serpinb9b	UTSW	13	33,223,806 (GRCm39)	missense	probably damaging	0.97
R5412:Serpinb9b	UTSW	13	33,213,496 (GRCm39)	missense	probably benign	0.00
R5481:Serpinb9b	UTSW	13	33,222,076 (GRCm39)	missense	possibly damaging	0.93
R5672:Serpinb9b	UTSW	13	33,223,582 (GRCm39)	missense	probably benign	0.01
R5957:Serpinb9b	UTSW	13	33,223,831 (GRCm39)	missense	possibly damaging	0.81
R6797:Serpinb9b	UTSW	13	33,213,467 (GRCm39)	missense	possibly damaging	0.60
R7586:Serpinb9b	UTSW	13	33,223,743 (GRCm39)	missense	probably damaging	1.00
R8115:Serpinb9b	UTSW	13	33,219,531 (GRCm39)	missense	probably null	0.94
R8309:Serpinb9b	UTSW	13	33,223,554 (GRCm39)	missense	probably damaging	1.00
R8529:Serpinb9b	UTSW	13	33,223,543 (GRCm39)	missense	probably benign	0.04
R8802:Serpinb9b	UTSW	13	33,213,587 (GRCm39)	missense	probably benign
R8810:Serpinb9b	UTSW	13	33,213,452 (GRCm39)	missense	possibly damaging	0.83
R9020:Serpinb9b	UTSW	13	33,223,887 (GRCm39)	missense	probably damaging	1.00
R9310:Serpinb9b	UTSW	13	33,219,523 (GRCm39)	missense	probably benign
R9424:Serpinb9b	UTSW	13	33,213,544 (GRCm39)	missense	probably damaging	0.99
X0019:Serpinb9b	UTSW	13	33,219,514 (GRCm39)	nonsense	probably null

Posted On

2015-04-16