Incidental Mutation 'IGL02633:Gzmg'
ID 301386
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gzmg
Ensembl Gene ENSMUSG00000040284
Gene Name granzyme G
Synonyms Ctla-7, Ctla7
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # IGL02633
Quality Score
Status
Chromosome 14
Chromosomal Location 56394039-56397036 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 56394160 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 245 (M245V)
Ref Sequence ENSEMBL: ENSMUSP00000015578 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000015578]
AlphaFold P13366
Predicted Effect probably damaging
Transcript: ENSMUST00000015578
AA Change: M245V

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000015578
Gene: ENSMUSG00000040284
AA Change: M245V

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Tryp_SPc 20 241 6.39e-82 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abitram T C 4: 56,806,131 (GRCm39) V181A possibly damaging Het
Aff4 T C 11: 53,300,198 (GRCm39) probably benign Het
Ap1g2 T C 14: 55,338,104 (GRCm39) probably null Het
Aspn A T 13: 49,705,363 (GRCm39) Y75F possibly damaging Het
Atm G A 9: 53,359,453 (GRCm39) T2783I probably damaging Het
Cacnb1 A T 11: 97,913,199 (GRCm39) I18N probably damaging Het
Casr T C 16: 36,336,017 (GRCm39) I97M probably damaging Het
Cnga2 T A X: 71,048,655 (GRCm39) probably benign Het
Coasy T A 11: 100,976,147 (GRCm39) L425Q probably damaging Het
Cps1 A G 1: 67,162,396 (GRCm39) T25A probably benign Het
Dnah1 T C 14: 31,006,772 (GRCm39) Y2181C probably benign Het
Efna3 A C 3: 89,222,749 (GRCm39) S230A probably damaging Het
Eng A G 2: 32,563,286 (GRCm39) I281V probably damaging Het
Erlec1 T A 11: 30,898,430 (GRCm39) R14* probably null Het
Gbp9 C T 5: 105,231,431 (GRCm39) probably benign Het
Kdm5a A G 6: 120,341,680 (GRCm39) I36V probably damaging Het
Krt87 A G 15: 101,389,095 (GRCm39) V79A probably damaging Het
Limd1 A T 9: 123,308,987 (GRCm39) probably benign Het
Lmo4 T C 3: 143,899,683 (GRCm39) S155G probably benign Het
Mrpl44 G A 1: 79,753,862 (GRCm39) V5I probably benign Het
Mrpl49 T C 19: 6,104,931 (GRCm39) T146A possibly damaging Het
Mrpl58 T C 11: 115,301,457 (GRCm39) probably benign Het
Nab1 C T 1: 52,529,292 (GRCm39) V202M probably damaging Het
Nav3 T A 10: 109,527,997 (GRCm39) M2229L probably benign Het
Notch2 C T 3: 98,024,013 (GRCm39) probably benign Het
Nub1 A G 5: 24,897,931 (GRCm39) I106V probably benign Het
Prom1 A T 5: 44,172,117 (GRCm39) S595T probably benign Het
Rbfox1 T A 16: 7,110,078 (GRCm39) S165R probably damaging Het
Sipa1l2 G A 8: 126,174,507 (GRCm39) T1257I probably damaging Het
Smarcc2 T C 10: 128,305,556 (GRCm39) S327P probably damaging Het
Tdpoz1 T C 3: 93,578,056 (GRCm39) M243V probably benign Het
Ttn G T 2: 76,549,289 (GRCm39) T23469K probably damaging Het
Ube2u T C 4: 100,339,971 (GRCm39) probably benign Het
Umodl1 T C 17: 31,208,462 (GRCm39) Y836H probably damaging Het
Vmn2r45 A G 7: 8,488,728 (GRCm39) Y101H probably benign Het
Vps13a T A 19: 16,697,772 (GRCm39) Q781L possibly damaging Het
Vwce G A 19: 10,625,858 (GRCm39) V457M probably damaging Het
Other mutations in Gzmg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02064:Gzmg APN 14 56,394,798 (GRCm39) missense probably benign 0.00
IGL02323:Gzmg APN 14 56,394,729 (GRCm39) missense probably benign 0.01
R0456:Gzmg UTSW 14 56,395,779 (GRCm39) missense probably damaging 1.00
R1368:Gzmg UTSW 14 56,395,263 (GRCm39) missense probably benign 0.41
R1663:Gzmg UTSW 14 56,394,265 (GRCm39) missense probably damaging 1.00
R2511:Gzmg UTSW 14 56,395,832 (GRCm39) missense probably benign 0.00
R3691:Gzmg UTSW 14 56,395,134 (GRCm39) splice site probably benign
R4509:Gzmg UTSW 14 56,394,210 (GRCm39) missense probably damaging 1.00
R6776:Gzmg UTSW 14 56,394,288 (GRCm39) missense probably damaging 1.00
R7175:Gzmg UTSW 14 56,396,979 (GRCm39) start codon destroyed probably null
R7502:Gzmg UTSW 14 56,394,284 (GRCm39) missense not run
R8022:Gzmg UTSW 14 56,394,903 (GRCm39) missense probably benign 0.15
R8255:Gzmg UTSW 14 56,395,753 (GRCm39) missense probably damaging 1.00
R8774:Gzmg UTSW 14 56,394,193 (GRCm39) missense probably benign 0.01
R8774-TAIL:Gzmg UTSW 14 56,394,193 (GRCm39) missense probably benign 0.01
R8949:Gzmg UTSW 14 56,396,926 (GRCm39) critical splice donor site probably null
R9187:Gzmg UTSW 14 56,394,714 (GRCm39) missense probably benign 0.00
R9422:Gzmg UTSW 14 56,395,812 (GRCm39) missense probably benign
Posted On 2015-04-16