Incidental Mutation 'IGL02633:Cnga2'
ID 301413
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cnga2
Ensembl Gene ENSMUSG00000005864
Gene Name cyclic nucleotide gated channel alpha 2
Synonyms Cnca, Cncg4, OCNC1
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02633
Quality Score
Status
Chromosome X
Chromosomal Location 71035455-71053824 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 71048655 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000006020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006020]
AlphaFold Q62398
Predicted Effect probably benign
Transcript: ENSMUST00000006020
SMART Domains Protein: ENSMUSP00000006020
Gene: ENSMUSG00000005864

DomainStartEndE-ValueType
low complexity region 11 24 N/A INTRINSIC
low complexity region 62 79 N/A INTRINSIC
low complexity region 113 129 N/A INTRINSIC
Pfam:Ion_trans 142 385 2.8e-30 PFAM
cNMP 456 580 4.54e-23 SMART
PDB:3SWY|C 599 642 2e-9 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145642
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a transmembrane protein that is a subunit of the nucleotide-gated olfactory ion channel. Knock out of this gene affects development of the olfactory epithelium and olfactory bulb. [provided by RefSeq, May 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal lethality within 2 days of birth, growth retardation, and abnormal olfactory neuron response to forskolin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abitram T C 4: 56,806,131 (GRCm39) V181A possibly damaging Het
Aff4 T C 11: 53,300,198 (GRCm39) probably benign Het
Ap1g2 T C 14: 55,338,104 (GRCm39) probably null Het
Aspn A T 13: 49,705,363 (GRCm39) Y75F possibly damaging Het
Atm G A 9: 53,359,453 (GRCm39) T2783I probably damaging Het
Cacnb1 A T 11: 97,913,199 (GRCm39) I18N probably damaging Het
Casr T C 16: 36,336,017 (GRCm39) I97M probably damaging Het
Coasy T A 11: 100,976,147 (GRCm39) L425Q probably damaging Het
Cps1 A G 1: 67,162,396 (GRCm39) T25A probably benign Het
Dnah1 T C 14: 31,006,772 (GRCm39) Y2181C probably benign Het
Efna3 A C 3: 89,222,749 (GRCm39) S230A probably damaging Het
Eng A G 2: 32,563,286 (GRCm39) I281V probably damaging Het
Erlec1 T A 11: 30,898,430 (GRCm39) R14* probably null Het
Gbp9 C T 5: 105,231,431 (GRCm39) probably benign Het
Gzmg T C 14: 56,394,160 (GRCm39) M245V probably damaging Het
Kdm5a A G 6: 120,341,680 (GRCm39) I36V probably damaging Het
Krt87 A G 15: 101,389,095 (GRCm39) V79A probably damaging Het
Limd1 A T 9: 123,308,987 (GRCm39) probably benign Het
Lmo4 T C 3: 143,899,683 (GRCm39) S155G probably benign Het
Mrpl44 G A 1: 79,753,862 (GRCm39) V5I probably benign Het
Mrpl49 T C 19: 6,104,931 (GRCm39) T146A possibly damaging Het
Mrpl58 T C 11: 115,301,457 (GRCm39) probably benign Het
Nab1 C T 1: 52,529,292 (GRCm39) V202M probably damaging Het
Nav3 T A 10: 109,527,997 (GRCm39) M2229L probably benign Het
Notch2 C T 3: 98,024,013 (GRCm39) probably benign Het
Nub1 A G 5: 24,897,931 (GRCm39) I106V probably benign Het
Prom1 A T 5: 44,172,117 (GRCm39) S595T probably benign Het
Rbfox1 T A 16: 7,110,078 (GRCm39) S165R probably damaging Het
Sipa1l2 G A 8: 126,174,507 (GRCm39) T1257I probably damaging Het
Smarcc2 T C 10: 128,305,556 (GRCm39) S327P probably damaging Het
Tdpoz1 T C 3: 93,578,056 (GRCm39) M243V probably benign Het
Ttn G T 2: 76,549,289 (GRCm39) T23469K probably damaging Het
Ube2u T C 4: 100,339,971 (GRCm39) probably benign Het
Umodl1 T C 17: 31,208,462 (GRCm39) Y836H probably damaging Het
Vmn2r45 A G 7: 8,488,728 (GRCm39) Y101H probably benign Het
Vps13a T A 19: 16,697,772 (GRCm39) Q781L possibly damaging Het
Vwce G A 19: 10,625,858 (GRCm39) V457M probably damaging Het
Other mutations in Cnga2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02512:Cnga2 APN X 71,052,531 (GRCm39) missense probably damaging 1.00
IGL03059:Cnga2 APN X 71,051,878 (GRCm39) missense probably damaging 1.00
IGL03215:Cnga2 APN X 71,052,772 (GRCm39) missense probably damaging 1.00
IGL03332:Cnga2 APN X 71,049,800 (GRCm39) missense probably damaging 1.00
R2128:Cnga2 UTSW X 71,051,394 (GRCm39) missense possibly damaging 0.95
R4486:Cnga2 UTSW X 71,049,733 (GRCm39) missense possibly damaging 0.58
R4487:Cnga2 UTSW X 71,049,733 (GRCm39) missense possibly damaging 0.58
R4489:Cnga2 UTSW X 71,049,733 (GRCm39) missense possibly damaging 0.58
Posted On 2015-04-16