Incidental Mutation 'IGL02634:Kank4'
ID301421
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kank4
Ensembl Gene ENSMUSG00000035407
Gene NameKN motif and ankyrin repeat domains 4
SynonymsAnkrd38
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.070) question?
Stock #IGL02634
Quality Score
Status
Chromosome4
Chromosomal Location98754898-98817537 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 98778827 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Leucine at position 461 (Q461L)
Ref Sequence ENSEMBL: ENSMUSP00000099851 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102790]
Predicted Effect probably benign
Transcript: ENSMUST00000102790
AA Change: Q461L

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000099851
Gene: ENSMUSG00000035407
AA Change: Q461L

DomainStartEndE-ValueType
Pfam:KN_motif 24 62 5.6e-26 PFAM
low complexity region 280 295 N/A INTRINSIC
low complexity region 300 320 N/A INTRINSIC
coiled coil region 345 409 N/A INTRINSIC
low complexity region 505 521 N/A INTRINSIC
low complexity region 600 624 N/A INTRINSIC
low complexity region 625 655 N/A INTRINSIC
low complexity region 685 709 N/A INTRINSIC
ANK 838 868 7.42e-4 SMART
ANK 877 905 2.08e3 SMART
ANK 910 939 1.11e-2 SMART
ANK 943 973 8.99e-3 SMART
ANK 977 1006 2.43e3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810046K07Rik A G 9: 51,291,755 L33P possibly damaging Het
Adamts2 T A 11: 50,792,721 C943* probably null Het
Arhgef28 A T 13: 98,051,058 V243D probably benign Het
Arrdc3 T A 13: 80,890,765 I62K probably damaging Het
Atm T C 9: 53,516,563 T416A probably benign Het
AW209491 A G 13: 14,637,683 T374A probably damaging Het
Brcc3 T C X: 75,436,098 probably benign Het
Ccdc181 T G 1: 164,279,945 S66A probably benign Het
Ccdc62 T C 5: 123,954,257 I435T probably benign Het
Cdc14b C A 13: 64,216,303 probably benign Het
Chst5 A G 8: 111,890,845 S48P probably damaging Het
Ciita C A 16: 10,508,713 S253Y probably damaging Het
Dock7 C T 4: 98,989,296 R1005H probably damaging Het
Dsg4 A T 18: 20,458,580 I459F probably benign Het
Enpep T C 3: 129,309,857 E361G probably damaging Het
Fblim1 T C 4: 141,583,111 D280G probably benign Het
Fignl1 G A 11: 11,802,756 R100* probably null Het
Ggcx G T 6: 72,418,303 A126S probably damaging Het
Hdgfl1 A G 13: 26,769,803 S96P probably benign Het
Iqgap2 G A 13: 95,628,114 L1541F probably damaging Het
Itga8 T C 2: 12,140,478 E888G possibly damaging Het
Klhl20 C T 1: 161,098,365 V438M probably damaging Het
Klrc3 A T 6: 129,643,208 S27R probably damaging Het
Ksr2 T C 5: 117,763,329 probably benign Het
Lrrc37a C T 11: 103,499,112 S1829N probably benign Het
Obscn A G 11: 59,054,785 L4585P probably damaging Het
Olfr480 T C 7: 108,066,771 N9S probably benign Het
Palm3 T G 8: 84,028,865 S335R probably damaging Het
Pcsk7 C T 9: 45,919,262 A446V possibly damaging Het
Penk A G 4: 4,134,065 L194P possibly damaging Het
Pkhd1l1 T C 15: 44,539,667 F2255S probably damaging Het
Plcd3 G A 11: 103,077,827 S31F probably damaging Het
Ppp6r2 C T 15: 89,275,477 Q456* probably null Het
Rbbp8nl T C 2: 180,280,895 D235G probably benign Het
Ror1 T A 4: 100,426,110 N457K probably benign Het
Rpgrip1l C A 8: 91,225,344 probably benign Het
Sdk1 T C 5: 141,610,032 F148L probably benign Het
Slc45a2 A T 15: 11,023,354 H348L probably benign Het
Smg8 C T 11: 87,086,672 A28T probably benign Het
Snx14 A G 9: 88,403,303 I436T probably damaging Het
Synj2 G A 17: 6,029,760 R1088H probably damaging Het
Tubb6 T C 18: 67,402,296 Y422H probably damaging Het
Unc13a T A 8: 71,655,701 I503F probably benign Het
Unc13d A G 11: 116,070,556 probably benign Het
Zp1 T C 19: 10,919,507 probably benign Het
Other mutations in Kank4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01069:Kank4 APN 4 98778395 missense probably damaging 0.99
IGL02883:Kank4 APN 4 98773453 missense possibly damaging 0.87
R0040:Kank4 UTSW 4 98779220 missense probably benign 0.03
R0040:Kank4 UTSW 4 98779220 missense probably benign 0.03
R0081:Kank4 UTSW 4 98778330 missense probably benign 0.02
R0219:Kank4 UTSW 4 98778465 missense probably benign 0.06
R0498:Kank4 UTSW 4 98779636 missense probably benign
R0609:Kank4 UTSW 4 98777105 missense probably damaging 0.99
R0855:Kank4 UTSW 4 98771444 missense probably damaging 1.00
R0865:Kank4 UTSW 4 98774663 splice site probably benign
R0961:Kank4 UTSW 4 98756519 missense probably benign 0.02
R1172:Kank4 UTSW 4 98765569 missense probably damaging 1.00
R1173:Kank4 UTSW 4 98765569 missense probably damaging 1.00
R1175:Kank4 UTSW 4 98765569 missense probably damaging 1.00
R1381:Kank4 UTSW 4 98779938 missense probably damaging 0.98
R1517:Kank4 UTSW 4 98779029 missense possibly damaging 0.83
R1573:Kank4 UTSW 4 98774836 nonsense probably null
R1668:Kank4 UTSW 4 98778896 missense probably damaging 0.98
R2051:Kank4 UTSW 4 98780102 missense probably damaging 0.99
R2253:Kank4 UTSW 4 98779226 missense probably damaging 0.99
R2656:Kank4 UTSW 4 98778957 missense probably damaging 0.99
R3801:Kank4 UTSW 4 98780133 missense probably damaging 0.97
R3802:Kank4 UTSW 4 98780133 missense probably damaging 0.97
R3804:Kank4 UTSW 4 98780133 missense probably damaging 0.97
R3945:Kank4 UTSW 4 98771280 missense probably damaging 1.00
R4172:Kank4 UTSW 4 98779121 missense probably damaging 1.00
R4502:Kank4 UTSW 4 98777098 missense possibly damaging 0.89
R4503:Kank4 UTSW 4 98777098 missense possibly damaging 0.89
R5024:Kank4 UTSW 4 98785661 missense probably damaging 0.99
R5105:Kank4 UTSW 4 98779159 missense probably benign 0.01
R5122:Kank4 UTSW 4 98756567 missense probably damaging 1.00
R5255:Kank4 UTSW 4 98778972 missense probably benign
R5484:Kank4 UTSW 4 98774785 missense probably benign
R5517:Kank4 UTSW 4 98774881 missense probably damaging 1.00
R5550:Kank4 UTSW 4 98771441 missense probably benign 0.27
R5667:Kank4 UTSW 4 98765461 critical splice donor site probably null
R5671:Kank4 UTSW 4 98765461 critical splice donor site probably null
R5865:Kank4 UTSW 4 98771393 missense possibly damaging 0.50
R6176:Kank4 UTSW 4 98765554 missense probably damaging 1.00
R6778:Kank4 UTSW 4 98761505 missense probably benign 0.01
R7084:Kank4 UTSW 4 98771345 missense probably damaging 1.00
R7085:Kank4 UTSW 4 98779946 missense probably benign
R7112:Kank4 UTSW 4 98761521 missense probably damaging 0.99
R8307:Kank4 UTSW 4 98778678 nonsense probably null
R8431:Kank4 UTSW 4 98779272 missense probably benign 0.33
R8447:Kank4 UTSW 4 98778492 missense probably damaging 0.99
R8483:Kank4 UTSW 4 98771378 missense probably damaging 1.00
R8505:Kank4 UTSW 4 98785676 start gained probably benign
X0027:Kank4 UTSW 4 98779923 missense probably benign 0.00
Z1176:Kank4 UTSW 4 98778294 frame shift probably null
Posted On2015-04-16