Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02634:Cdc14b'

301457

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cdc14b

Ensembl Gene

ENSMUSG00000033102

Gene Name

CDC14 cell division cycle 14B

Synonyms

A530086E13Rik, 2810432N10Rik

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.261) question?

Stock #

IGL02634

Quality Score

Status

Chromosome

Chromosomal Location

64189268-64275290 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

C to A at 64216303 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000152388 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039318] [ENSMUST00000109769] [ENSMUST00000109770] [ENSMUST00000221139] [ENSMUST00000221634]

Predicted Effect

probably benign
Transcript: ENSMUST00000039318

SMART Domains

Protein: ENSMUSP00000046003
Gene: ENSMUSG00000033102

Domain	Start	End	E-Value	Type
low complexity region	15	34	N/A	INTRINSIC
Pfam:DSPn	51	189	6.1e-57	PFAM
Pfam:DSPc	240	365	9.2e-17	PFAM
Pfam:Y_phosphatase	244	365	1e-7	PFAM
transmembrane domain	445	467	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000109769

SMART Domains

Protein: ENSMUSP00000105391
Gene: ENSMUSG00000033102

Domain	Start	End	E-Value	Type
Pfam:DSPn	12	152	2.5e-58	PFAM
Pfam:DSPc	203	328	8e-17	PFAM
Pfam:Y_phosphatase	206	328	8.9e-8	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000109770

SMART Domains

Protein: ENSMUSP00000105392
Gene: ENSMUSG00000033102

Domain	Start	End	E-Value	Type
low complexity region	15	34	N/A	INTRINSIC
Pfam:DSPn	51	189	3.4e-57	PFAM
Pfam:DSPc	240	365	2.8e-16	PFAM
Pfam:Y_phosphatase	252	364	2.4e-7	PFAM
transmembrane domain	445	467	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000221139

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221437

Predicted Effect

probably benign
Transcript: ENSMUST00000221634

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223116

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit premature aging, including premature cataracts and kyphosis; reduced fertility, particularly in female mice; and impaired contextual conditioning. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810046K07Rik	A	G	9: 51,291,755	L33P	possibly damaging	Het
Adamts2	T	A	11: 50,792,721	C943*	probably null	Het
Arhgef28	A	T	13: 98,051,058	V243D	probably benign	Het
Arrdc3	T	A	13: 80,890,765	I62K	probably damaging	Het
Atm	T	C	9: 53,516,563	T416A	probably benign	Het
AW209491	A	G	13: 14,637,683	T374A	probably damaging	Het
Brcc3	T	C	X: 75,436,098		probably benign	Het
Ccdc181	T	G	1: 164,279,945	S66A	probably benign	Het
Ccdc62	T	C	5: 123,954,257	I435T	probably benign	Het
Chst5	A	G	8: 111,890,845	S48P	probably damaging	Het
Ciita	C	A	16: 10,508,713	S253Y	probably damaging	Het
Dock7	C	T	4: 98,989,296	R1005H	probably damaging	Het
Dsg4	A	T	18: 20,458,580	I459F	probably benign	Het
Enpep	T	C	3: 129,309,857	E361G	probably damaging	Het
Fblim1	T	C	4: 141,583,111	D280G	probably benign	Het
Fignl1	G	A	11: 11,802,756	R100*	probably null	Het
Ggcx	G	T	6: 72,418,303	A126S	probably damaging	Het
Hdgfl1	A	G	13: 26,769,803	S96P	probably benign	Het
Iqgap2	G	A	13: 95,628,114	L1541F	probably damaging	Het
Itga8	T	C	2: 12,140,478	E888G	possibly damaging	Het
Kank4	T	A	4: 98,778,827	Q461L	probably benign	Het
Klhl20	C	T	1: 161,098,365	V438M	probably damaging	Het
Klrc3	A	T	6: 129,643,208	S27R	probably damaging	Het
Ksr2	T	C	5: 117,763,329		probably benign	Het
Lrrc37a	C	T	11: 103,499,112	S1829N	probably benign	Het
Obscn	A	G	11: 59,054,785	L4585P	probably damaging	Het
Olfr480	T	C	7: 108,066,771	N9S	probably benign	Het
Palm3	T	G	8: 84,028,865	S335R	probably damaging	Het
Pcsk7	C	T	9: 45,919,262	A446V	possibly damaging	Het
Penk	A	G	4: 4,134,065	L194P	possibly damaging	Het
Pkhd1l1	T	C	15: 44,539,667	F2255S	probably damaging	Het
Plcd3	G	A	11: 103,077,827	S31F	probably damaging	Het
Ppp6r2	C	T	15: 89,275,477	Q456*	probably null	Het
Rbbp8nl	T	C	2: 180,280,895	D235G	probably benign	Het
Ror1	T	A	4: 100,426,110	N457K	probably benign	Het
Rpgrip1l	C	A	8: 91,225,344		probably benign	Het
Sdk1	T	C	5: 141,610,032	F148L	probably benign	Het
Slc45a2	A	T	15: 11,023,354	H348L	probably benign	Het
Smg8	C	T	11: 87,086,672	A28T	probably benign	Het
Snx14	A	G	9: 88,403,303	I436T	probably damaging	Het
Synj2	G	A	17: 6,029,760	R1088H	probably damaging	Het
Tubb6	T	C	18: 67,402,296	Y422H	probably damaging	Het
Unc13a	T	A	8: 71,655,701	I503F	probably benign	Het
Unc13d	A	G	11: 116,070,556		probably benign	Het
Zp1	T	C	19: 10,919,507		probably benign	Het

Other mutations in Cdc14b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00778:Cdc14b	APN	13	64215656	missense	probably damaging	1.00
IGL00816:Cdc14b	APN	13	64205403	missense	probably benign	0.10
IGL02569:Cdc14b	APN	13	64225614	missense	probably benign	0.36
IGL02897:Cdc14b	APN	13	64247253	missense	probably benign	0.00
R0390:Cdc14b	UTSW	13	64210192	unclassified	probably benign
R0542:Cdc14b	UTSW	13	64243683	missense	probably benign	0.01
R1022:Cdc14b	UTSW	13	64215676	missense	probably damaging	1.00
R1024:Cdc14b	UTSW	13	64215676	missense	probably damaging	1.00
R1676:Cdc14b	UTSW	13	64225602	missense	possibly damaging	0.93
R1945:Cdc14b	UTSW	13	64219890	missense	probably damaging	1.00
R1964:Cdc14b	UTSW	13	64215537	missense	probably damaging	1.00
R3162:Cdc14b	UTSW	13	64246608	splice site	probably benign
R4359:Cdc14b	UTSW	13	64248411	missense	probably benign	0.27
R4598:Cdc14b	UTSW	13	64247274	missense	probably benign
R4716:Cdc14b	UTSW	13	64209200	missense	probably damaging	1.00
R6196:Cdc14b	UTSW	13	64205524	intron	probably benign
R6219:Cdc14b	UTSW	13	64205524	intron	probably benign
R6361:Cdc14b	UTSW	13	64216209	splice site	probably null
R6480:Cdc14b	UTSW	13	64225650	critical splice acceptor site	probably null
R6565:Cdc14b	UTSW	13	64225630	missense	probably benign	0.01
R6692:Cdc14b	UTSW	13	64215563	missense	probably damaging	0.98
R7204:Cdc14b	UTSW	13	64210198	missense	possibly damaging	0.83
R7327:Cdc14b	UTSW	13	64225647	missense	probably damaging	1.00
R7464:Cdc14b	UTSW	13	64196675	nonsense	probably null
R7639:Cdc14b	UTSW	13	64205329	missense	possibly damaging	0.96
R7687:Cdc14b	UTSW	13	64209193	missense	probably benign	0.15
R7949:Cdc14b	UTSW	13	64190398	splice site	probably null
R8170:Cdc14b	UTSW	13	64215735	splice site	probably null
Z1176:Cdc14b	UTSW	13	64274669	missense	possibly damaging	0.66

Posted On

2015-04-16