Incidental Mutation 'IGL02636:Rab26'
ID 301513
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rab26
Ensembl Gene ENSMUSG00000079657
Gene Name RAB26, member RAS oncogene family
Synonyms A830020M03Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # IGL02636
Quality Score
Status
Chromosome 17
Chromosomal Location 24748038-24752696 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 24752533 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 9 (S9G)
Ref Sequence ENSEMBL: ENSMUSP00000055970 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035797] [ENSMUST00000061764] [ENSMUST00000176533]
AlphaFold Q504M8
Predicted Effect probably benign
Transcript: ENSMUST00000035797
AA Change: S9G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000046089
Gene: ENSMUSG00000079657
AA Change: S9G

DomainStartEndE-ValueType
low complexity region 40 50 N/A INTRINSIC
RAB 68 232 2.84e-101 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000061764
AA Change: S9G

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000055970
Gene: ENSMUSG00000079657
AA Change: S9G

DomainStartEndE-ValueType
low complexity region 40 50 N/A INTRINSIC
Pfam:Arf 59 145 1.1e-8 PFAM
Pfam:Ras 69 145 6.6e-27 PFAM
Pfam:Roc 69 157 4.7e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176025
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176215
Predicted Effect probably benign
Transcript: ENSMUST00000176533
AA Change: S44G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000135775
Gene: ENSMUSG00000079657
AA Change: S44G

DomainStartEndE-ValueType
low complexity region 75 85 N/A INTRINSIC
RAB 103 267 2.84e-101 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176921
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177441
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alms1 C A 6: 85,605,636 (GRCm39) Q1960K probably benign Het
Arhgef40 T A 14: 52,234,865 (GRCm39) V1056E probably damaging Het
Cdh26 T A 2: 178,091,755 (GRCm39) F105I probably damaging Het
Cep162 A T 9: 87,130,432 (GRCm39) D59E possibly damaging Het
Cngb3 A T 4: 19,396,690 (GRCm39) T348S probably damaging Het
Eci3 A T 13: 35,130,963 (GRCm39) probably null Het
Gapvd1 A G 2: 34,615,416 (GRCm39) I409T probably benign Het
Golga2 T C 2: 32,186,735 (GRCm39) probably null Het
Hoxd3 G A 2: 74,577,298 (GRCm39) A393T probably benign Het
Htr5a T C 5: 28,047,658 (GRCm39) F71S probably damaging Het
Hyou1 T C 9: 44,292,707 (GRCm39) probably null Het
Igsf6 C A 7: 120,666,503 (GRCm39) probably benign Het
Klrb1c C A 6: 128,765,515 (GRCm39) C25F probably benign Het
Lrguk C A 6: 34,067,123 (GRCm39) T483K probably damaging Het
Lrpprc A T 17: 85,060,532 (GRCm39) probably benign Het
Lrrk1 A T 7: 65,958,407 (GRCm39) probably null Het
Megf8 G A 7: 25,057,857 (GRCm39) G2098D probably damaging Het
Nfkbia T C 12: 55,537,958 (GRCm39) Q165R possibly damaging Het
Nipsnap2 A G 5: 129,822,354 (GRCm39) probably benign Het
Phykpl C T 11: 51,489,540 (GRCm39) T382I probably damaging Het
Prdm10 A G 9: 31,240,977 (GRCm39) D206G possibly damaging Het
Sema3e C A 5: 14,275,670 (GRCm39) N258K probably benign Het
Slfn10-ps T A 11: 82,920,971 (GRCm39) noncoding transcript Het
Tgm5 A T 2: 120,907,277 (GRCm39) C149S probably damaging Het
Timp4 C T 6: 115,226,785 (GRCm39) probably null Het
Traf7 T C 17: 24,731,964 (GRCm39) K251E probably benign Het
Ugcg G T 4: 59,207,763 (GRCm39) R34L possibly damaging Het
Unc13d T C 11: 115,964,444 (GRCm39) H300R probably damaging Het
Vmn1r20 G T 6: 57,408,746 (GRCm39) C24F probably benign Het
Vmn2r13 T C 5: 109,339,883 (GRCm39) R31G probably damaging Het
Vsig10l A G 7: 43,113,002 (GRCm39) T87A possibly damaging Het
Zfp353-ps T A 8: 42,535,477 (GRCm39) noncoding transcript Het
Other mutations in Rab26
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0131:Rab26 UTSW 17 24,749,759 (GRCm39) critical splice donor site probably null
R0131:Rab26 UTSW 17 24,749,759 (GRCm39) critical splice donor site probably null
R0132:Rab26 UTSW 17 24,749,759 (GRCm39) critical splice donor site probably null
R0377:Rab26 UTSW 17 24,749,019 (GRCm39) unclassified probably benign
R0567:Rab26 UTSW 17 24,748,556 (GRCm39) missense probably damaging 0.99
R0681:Rab26 UTSW 17 24,746,940 (GRCm39) unclassified probably benign
R5103:Rab26 UTSW 17 24,753,071 (GRCm39) unclassified probably benign
R5226:Rab26 UTSW 17 24,753,107 (GRCm39) unclassified probably benign
R5975:Rab26 UTSW 17 24,749,373 (GRCm39) missense possibly damaging 0.94
R6307:Rab26 UTSW 17 24,749,072 (GRCm39) missense probably damaging 1.00
R6601:Rab26 UTSW 17 24,748,595 (GRCm39) nonsense probably null
R6897:Rab26 UTSW 17 24,748,766 (GRCm39) missense probably damaging 1.00
R7122:Rab26 UTSW 17 24,749,652 (GRCm39) missense probably damaging 1.00
R7155:Rab26 UTSW 17 24,751,263 (GRCm39) missense probably damaging 0.99
R8708:Rab26 UTSW 17 24,748,772 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16