Incidental Mutation 'IGL02636:Igsf6'
ID301536
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igsf6
Ensembl Gene ENSMUSG00000035004
Gene Nameimmunoglobulin superfamily, member 6
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.079) question?
Stock #IGL02636
Quality Score
Status
Chromosome7
Chromosomal Location121064067-121074572 bp(-) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) C to A at 121067280 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147071 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033163] [ENSMUST00000047194] [ENSMUST00000207351]
Predicted Effect probably benign
Transcript: ENSMUST00000033163
SMART Domains Protein: ENSMUSP00000033163
Gene: ENSMUSG00000030876

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 39 50 N/A INTRINSIC
Pfam:DREV 56 317 1.4e-142 PFAM
Pfam:Methyltransf_23 123 289 2.7e-12 PFAM
Pfam:Methyltransf_12 150 236 9.1e-10 PFAM
Pfam:Methyltransf_11 150 238 9.4e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000047194
SMART Domains Protein: ENSMUSP00000039059
Gene: ENSMUSG00000035004

DomainStartEndE-ValueType
IG 35 142 2.79e-2 SMART
transmembrane domain 154 176 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000207351
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207806
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alms1 C A 6: 85,628,654 Q1960K probably benign Het
Arhgef40 T A 14: 51,997,408 V1056E probably damaging Het
Cdh26 T A 2: 178,449,962 F105I probably damaging Het
Cep162 A T 9: 87,248,379 D59E possibly damaging Het
Cngb3 A T 4: 19,396,690 T348S probably damaging Het
Eci3 A T 13: 34,946,980 probably null Het
Gapvd1 A G 2: 34,725,404 I409T probably benign Het
Golga2 T C 2: 32,296,723 probably null Het
Hoxd3 G A 2: 74,746,954 A393T probably benign Het
Htr5a T C 5: 27,842,660 F71S probably damaging Het
Hyou1 T C 9: 44,381,410 probably null Het
Klrb1c C A 6: 128,788,552 C25F probably benign Het
Lrguk C A 6: 34,090,188 T483K probably damaging Het
Lrpprc A T 17: 84,753,104 probably benign Het
Lrrk1 A T 7: 66,308,659 probably null Het
Megf8 G A 7: 25,358,432 G2098D probably damaging Het
Nfkbia T C 12: 55,491,173 Q165R possibly damaging Het
Nipsnap2 A G 5: 129,745,290 probably benign Het
Phykpl C T 11: 51,598,713 T382I probably damaging Het
Prdm10 A G 9: 31,329,681 D206G possibly damaging Het
Rab26 T C 17: 24,533,559 S9G probably benign Het
Sema3e C A 5: 14,225,656 N258K probably benign Het
Slfn10-ps T A 11: 83,030,145 noncoding transcript Het
Tgm5 A T 2: 121,076,796 C149S probably damaging Het
Timp4 C T 6: 115,249,824 probably null Het
Traf7 T C 17: 24,512,990 K251E probably benign Het
Ugcg G T 4: 59,207,763 R34L possibly damaging Het
Unc13d T C 11: 116,073,618 H300R probably damaging Het
Vmn1r20 G T 6: 57,431,761 C24F probably benign Het
Vmn2r13 T C 5: 109,192,017 R31G probably damaging Het
Vsig10l A G 7: 43,463,578 T87A possibly damaging Het
Zfp353-ps T A 8: 42,082,440 noncoding transcript Het
Other mutations in Igsf6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Igsf6 APN 7 121070653 nonsense probably null
IGL01592:Igsf6 APN 7 121070793 missense probably damaging 1.00
IGL02519:Igsf6 APN 7 121068273 missense possibly damaging 0.72
R0106:Igsf6 UTSW 7 121074454 missense probably benign 0.28
R0106:Igsf6 UTSW 7 121074454 missense probably benign 0.28
R1776:Igsf6 UTSW 7 121068299 missense probably damaging 0.97
R1817:Igsf6 UTSW 7 121070808 missense probably damaging 1.00
R7770:Igsf6 UTSW 7 121068325 missense probably benign 0.01
Posted On2015-04-16