Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02639:Eif1ad14'

301641

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Eif1ad14

Ensembl Gene

ENSMUSG00000096619

Gene Name

eukaryotic translation initiation factor 1A domain containing 14

Synonyms

Gm2035

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.341) question?

Stock #

IGL02639

Quality Score

Status

Chromosome

Chromosomal Location

87886193-87886627 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 87886269 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 120 (T120K)

Ref Sequence

ENSEMBL: ENSMUSP00000137146 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000180053]

AlphaFold

J3QP87

Predicted Effect

probably benign
Transcript: ENSMUST00000180053
AA Change: T120K

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000137146
Gene: ENSMUSG00000096619
AA Change: T120K

Domain	Start	End	E-Value	Type
low complexity region	3	25	N/A	INTRINSIC
eIF1a	28	110	4.13e-45	SMART
low complexity region	125	144	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930447A16Rik	C	T	15: 37,430,048 (GRCm39)	R71*	probably null	Het
Abca5	A	T	11: 110,178,899 (GRCm39)	I1140N	possibly damaging	Het
Atp6v0a1	T	A	11: 100,946,344 (GRCm39)	I773N	possibly damaging	Het
Atp9a	A	G	2: 168,491,540 (GRCm39)	M675T	probably damaging	Het
Baz1a	A	G	12: 54,942,810 (GRCm39)		probably benign	Het
Cd5l	T	C	3: 87,275,813 (GRCm39)	V261A	probably damaging	Het
Copb1	A	G	7: 113,825,830 (GRCm39)		probably benign	Het
Cul5	T	C	9: 53,566,642 (GRCm39)	D130G	possibly damaging	Het
Cyp2j5	T	A	4: 96,546,986 (GRCm39)	Q176L	probably benign	Het
Ddo	A	G	10: 40,523,733 (GRCm39)	D241G	probably damaging	Het
Defa29	A	G	8: 21,816,137 (GRCm39)	C77R	possibly damaging	Het
Dpp4	T	C	2: 62,182,584 (GRCm39)	N566D	probably benign	Het
Emilin2	T	C	17: 71,581,544 (GRCm39)	D394G	probably benign	Het
Fbf1	T	C	11: 116,043,426 (GRCm39)	E461G	probably benign	Het
Fgfr2	A	G	7: 129,830,532 (GRCm39)		probably benign	Het
Fibcd1	G	A	2: 31,707,162 (GRCm39)	T365M	probably damaging	Het
Fndc3a	A	C	14: 72,811,797 (GRCm39)	H344Q	probably benign	Het
Fnip1	T	A	11: 54,366,466 (GRCm39)	C52*	probably null	Het
Fto	T	A	8: 92,136,156 (GRCm39)	N143K	probably damaging	Het
Hells	G	T	19: 38,926,873 (GRCm39)	L84F	probably damaging	Het
Hydin	G	A	8: 111,265,081 (GRCm39)	V2755I	probably benign	Het
Irgq	C	A	7: 24,230,887 (GRCm39)	A26E	probably damaging	Het
Katnip	A	G	7: 125,471,964 (GRCm39)	I1518V	probably damaging	Het
Klhl29	A	T	12: 5,187,453 (GRCm39)	Y304N	probably damaging	Het
Muc6	T	C	7: 141,235,843 (GRCm39)		probably benign	Het
Myo15a	T	C	11: 60,369,447 (GRCm39)	F736L	probably benign	Het
Nynrin	G	T	14: 56,108,112 (GRCm39)	W1073L	probably damaging	Het
Or10h28	G	A	17: 33,488,369 (GRCm39)	V224M	possibly damaging	Het
Or10w1	A	T	19: 13,631,960 (GRCm39)	T51S	possibly damaging	Het
Or14c46	A	T	7: 85,918,928 (GRCm39)	I23N	probably damaging	Het
Or14j10	A	T	17: 37,934,878 (GRCm39)	I216N	probably benign	Het
Or1e29	A	T	11: 73,667,371 (GRCm39)	C261S	probably benign	Het
Or51a10	C	A	7: 103,698,988 (GRCm39)	C191F	probably damaging	Het
Or52e8b	T	A	7: 104,673,429 (GRCm39)	I253F	probably damaging	Het
Pdzd2	T	A	15: 12,592,329 (GRCm39)	K105M	probably damaging	Het
Pip5k1c	C	A	10: 81,153,155 (GRCm39)		probably null	Het
Pola2	A	G	19: 6,003,802 (GRCm39)	V191A	probably benign	Het
Slc22a8	A	T	19: 8,571,323 (GRCm39)	Y18F	probably benign	Het
Slc26a5	C	T	5: 22,024,765 (GRCm39)	V440M	probably damaging	Het

Other mutations in Eif1ad14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02314:Eif1ad14	APN	12	87,886,377 (GRCm39)	missense	probably benign	0.00
IGL02347:Eif1ad14	APN	12	87,886,359 (GRCm39)	missense	probably damaging	1.00
R4230:Eif1ad14	UTSW	12	87,886,567 (GRCm39)	missense	unknown
R5969:Eif1ad14	UTSW	12	87,886,248 (GRCm39)	missense	unknown
R6159:Eif1ad14	UTSW	12	87,886,521 (GRCm39)	missense	probably damaging	1.00
R6359:Eif1ad14	UTSW	12	87,886,275 (GRCm39)	missense	probably benign	0.09
R7181:Eif1ad14	UTSW	12	87,886,492 (GRCm39)	missense	possibly damaging	0.49
R7183:Eif1ad14	UTSW	12	87,886,492 (GRCm39)	missense	possibly damaging	0.49
R7184:Eif1ad14	UTSW	12	87,886,492 (GRCm39)	missense	possibly damaging	0.49
R7653:Eif1ad14	UTSW	12	87,886,248 (GRCm39)	missense	unknown
R8046:Eif1ad14	UTSW	12	87,886,335 (GRCm39)	missense	probably benign	0.02
R8353:Eif1ad14	UTSW	12	87,886,323 (GRCm39)	missense	probably benign
R8453:Eif1ad14	UTSW	12	87,886,323 (GRCm39)	missense	probably benign

Posted On

2015-04-16