Incidental Mutation 'IGL02639:Olfr642'
ID301661
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr642
Ensembl Gene ENSMUSG00000049797
Gene Nameolfactory receptor 642
SynonymsMOR13-6, GA_x6K02T2PBJ9-6784380-6783436
Accession Numbers

Genbank: NM_146329.1

Is this an essential gene? Probably non essential (E-score: 0.092) question?
Stock #IGL02639
Quality Score
Status
Chromosome7
Chromosomal Location104046529-104052666 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 104049781 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Phenylalanine at position 191 (C191F)
Ref Sequence ENSEMBL: ENSMUSP00000148961 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052660] [ENSMUST00000074064] [ENSMUST00000138055] [ENSMUST00000214299]
Predicted Effect probably damaging
Transcript: ENSMUST00000052660
AA Change: C191F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000061462
Gene: ENSMUSG00000049797
AA Change: C191F

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 8.5e-119 PFAM
Pfam:7TM_GPCR_Srsx 37 309 1.7e-7 PFAM
Pfam:7tm_1 43 294 4.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000074064
SMART Domains Protein: ENSMUSP00000073707
Gene: ENSMUSG00000090219

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 2.6e-124 PFAM
Pfam:7TM_GPCR_Srsx 37 255 3.1e-7 PFAM
Pfam:7tm_1 43 294 3.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000214299
AA Change: C191F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930447A16Rik C T 15: 37,429,804 R71* probably null Het
Abca5 A T 11: 110,288,073 I1140N possibly damaging Het
Atp6v0a1 T A 11: 101,055,518 I773N possibly damaging Het
Atp9a A G 2: 168,649,620 M675T probably damaging Het
Baz1a A G 12: 54,896,025 probably benign Het
Cd5l T C 3: 87,368,506 V261A probably damaging Het
Copb1 A G 7: 114,226,595 probably benign Het
Cul5 T C 9: 53,655,342 D130G possibly damaging Het
Cyp2j5 T A 4: 96,658,749 Q176L probably benign Het
D430042O09Rik A G 7: 125,872,792 I1518V probably damaging Het
Ddo A G 10: 40,647,737 D241G probably damaging Het
Defa29 A G 8: 21,326,121 C77R possibly damaging Het
Dpp4 T C 2: 62,352,240 N566D probably benign Het
Emilin2 T C 17: 71,274,549 D394G probably benign Het
Fbf1 T C 11: 116,152,600 E461G probably benign Het
Fgfr2 A G 7: 130,228,802 probably benign Het
Fibcd1 G A 2: 31,817,150 T365M probably damaging Het
Fndc3a A C 14: 72,574,357 H344Q probably benign Het
Fnip1 T A 11: 54,475,640 C52* probably null Het
Fto T A 8: 91,409,528 N143K probably damaging Het
Gm2035 G T 12: 87,919,499 T120K probably benign Het
Hells G T 19: 38,938,429 L84F probably damaging Het
Hydin G A 8: 110,538,449 V2755I probably benign Het
Irgq C A 7: 24,531,462 A26E probably damaging Het
Klhl29 A T 12: 5,137,453 Y304N probably damaging Het
Muc6 T C 7: 141,649,578 probably benign Het
Myo15 T C 11: 60,478,621 F736L probably benign Het
Nynrin G T 14: 55,870,655 W1073L probably damaging Het
Olfr116 A T 17: 37,623,987 I216N probably benign Het
Olfr1490 A T 19: 13,654,596 T51S possibly damaging Het
Olfr310 A T 7: 86,269,720 I23N probably damaging Het
Olfr389 A T 11: 73,776,545 C261S probably benign Het
Olfr63 G A 17: 33,269,395 V224M possibly damaging Het
Olfr675 T A 7: 105,024,222 I253F probably damaging Het
Pdzd2 T A 15: 12,592,243 K105M probably damaging Het
Pip5k1c C A 10: 81,317,321 probably null Het
Pola2 A G 19: 5,953,774 V191A probably benign Het
Slc22a8 A T 19: 8,593,959 Y18F probably benign Het
Slc26a5 C T 5: 21,819,767 V440M probably damaging Het
Other mutations in Olfr642
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01457:Olfr642 APN 7 104050169 missense probably damaging 1.00
IGL01933:Olfr642 APN 7 104049814 missense probably damaging 1.00
IGL01980:Olfr642 APN 7 104050093 missense probably benign 0.21
IGL02161:Olfr642 APN 7 104049590 missense possibly damaging 0.66
I2289:Olfr642 UTSW 7 104049754 missense probably damaging 1.00
R0418:Olfr642 UTSW 7 104049772 missense probably benign 0.00
R1647:Olfr642 UTSW 7 104050169 missense probably damaging 1.00
R1648:Olfr642 UTSW 7 104050169 missense probably damaging 1.00
R1701:Olfr642 UTSW 7 104050195 missense possibly damaging 0.95
R2142:Olfr642 UTSW 7 104050300 missense probably damaging 1.00
R2165:Olfr642 UTSW 7 104049638 missense probably benign 0.22
R2655:Olfr642 UTSW 7 104049431 missense probably benign 0.03
R6216:Olfr642 UTSW 7 104049695 missense probably damaging 1.00
R6759:Olfr642 UTSW 7 104050127 missense probably damaging 1.00
R6925:Olfr642 UTSW 7 104049740 missense probably benign 0.16
R7243:Olfr642 UTSW 7 104049755 missense probably damaging 1.00
R7684:Olfr642 UTSW 7 104049460 missense probably damaging 0.99
R7699:Olfr642 UTSW 7 104050593 start gained probably benign
R8316:Olfr642 UTSW 7 104049622 missense probably damaging 1.00
R8458:Olfr642 UTSW 7 104049668 missense possibly damaging 0.93
Z1176:Olfr642 UTSW 7 104050273 missense probably benign
Posted On2015-04-16