Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02641:Ighg3'

301727

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ighg3

Ensembl Gene

ENSMUSG00000076615

Gene Name

Immunoglobulin heavy constant gamma 3

Synonyms

IgG3, AI324046

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL02641

Quality Score

Status

Chromosome

Chromosomal Location

113321062-113324852 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 113323818 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 190 (I190T)

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000103423
AA Change: I190T

SMART Domains

Protein: ENSMUSP00000100219
Gene: ENSMUSG00000076615
AA Change: I190T

Domain	Start	End	E-Value	Type
IGc1	22	92	3.42e-20	SMART
low complexity region	102	114	N/A	INTRINSIC
IG_like	139	214	5.06e-3	SMART
IGc1	245	318	2.9e-32	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000223179
AA Change: I190T

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3100002H09Rik	A	T	4: 124,504,510 (GRCm39)	M14K	unknown	Het
Arhgap24	T	C	5: 103,040,386 (GRCm39)	V441A	probably damaging	Het
Cdv3	G	T	9: 103,241,223 (GRCm39)	Q115K	probably damaging	Het
Clstn1	G	T	4: 149,713,968 (GRCm39)	G207C	probably null	Het
Col28a1	A	T	6: 8,014,794 (GRCm39)	Y870*	probably null	Het
Creb3	A	C	4: 43,563,311 (GRCm39)	H136P	probably benign	Het
Dcaf17	G	A	2: 70,912,375 (GRCm39)	C320Y	probably damaging	Het
Fbl	T	C	7: 27,874,471 (GRCm39)	S66P	probably damaging	Het
Fgfrl1	C	A	5: 108,853,731 (GRCm39)	S279R	probably damaging	Het
Gdpgp1	C	T	7: 79,888,796 (GRCm39)	R276*	probably null	Het
Hcfc2	A	G	10: 82,538,383 (GRCm39)	Y140C	probably damaging	Het
Itgav	T	C	2: 83,598,689 (GRCm39)		probably benign	Het
Lce1c	C	A	3: 92,587,845 (GRCm39)		probably benign	Het
Ldoc1	G	A	X: 60,753,419 (GRCm39)	C35Y	probably damaging	Het
Lrp10	T	A	14: 54,706,068 (GRCm39)	C419*	probably null	Het
Micall2	T	C	5: 139,705,094 (GRCm39)	D80G	probably damaging	Het
Or5b21	T	A	19: 12,839,566 (GRCm39)	C142*	probably null	Het
Pde3b	C	T	7: 114,130,052 (GRCm39)	T869I	probably damaging	Het
Pip5k1c	C	A	10: 81,153,155 (GRCm39)		probably null	Het
Pkhd1	G	A	1: 20,628,976 (GRCm39)	T657I	possibly damaging	Het
Pnisr	A	G	4: 21,860,908 (GRCm39)	N197S	probably benign	Het
Rpl21-ps4	G	A	14: 11,227,661 (GRCm38)		noncoding transcript	Het
Rtn4rl1	A	C	11: 75,156,650 (GRCm39)	T361P	probably damaging	Het
Spaca9	C	A	2: 28,585,963 (GRCm39)	E34*	probably null	Het
Trip10	T	A	17: 57,569,411 (GRCm39)	D478E	probably benign	Het
Tsc22d2	A	G	3: 58,323,576 (GRCm39)	D156G	probably damaging	Het
Ufc1	T	C	1: 171,117,764 (GRCm39)	D50G	probably damaging	Het
Vmn1r202	T	G	13: 22,686,274 (GRCm39)	I48L	probably benign	Het
Vmn2r111	A	T	17: 22,792,205 (GRCm39)	V17E	possibly damaging	Het
Vps13a	T	A	19: 16,676,185 (GRCm39)	M1263L	probably benign	Het

Other mutations in Ighg3

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL00230:Ighg3	APN	12	113,323,457 (GRCm39)	missense	unknown
IGL03252:Ighg3	APN	12	113,324,184 (GRCm39)	missense	unknown
R0630:Ighg3	UTSW	12	113,323,714 (GRCm39)	splice site	probably benign
R4957:Ighg3	UTSW	12	113,324,750 (GRCm39)	missense	unknown
R6407:Ighg3	UTSW	12	113,323,770 (GRCm39)	missense	unknown
R6745:Ighg3	UTSW	12	113,323,890 (GRCm39)	missense	unknown
R7801:Ighg3	UTSW	12	113,323,436 (GRCm39)	missense
R7824:Ighg3	UTSW	12	113,323,426 (GRCm39)	missense
R8075:Ighg3	UTSW	12	113,321,097 (GRCm39)	missense
R8076:Ighg3	UTSW	12	113,324,158 (GRCm39)	missense	probably benign
R8887:Ighg3	UTSW	12	113,323,845 (GRCm39)	missense
R9314:Ighg3	UTSW	12	113,323,946 (GRCm39)	missense

Posted On

2015-04-16