Incidental Mutation 'IGL02643:Six5'
ID301807
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Six5
Ensembl Gene ENSMUSG00000040841
Gene Namesine oculis-related homeobox 5
SynonymsDmahp, MDMAHP, TrexBF
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.750) question?
Stock #IGL02643
Quality Score
Status
Chromosome7
Chromosomal Location19094594-19098549 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 19097530 bp
ZygosityHeterozygous
Amino Acid Change Valine to Leucine at position 649 (V649L)
Ref Sequence ENSEMBL: ENSMUSP00000045973 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032568] [ENSMUST00000049454] [ENSMUST00000108473] [ENSMUST00000108474] [ENSMUST00000127433] [ENSMUST00000141380] [ENSMUST00000154199]
Predicted Effect probably benign
Transcript: ENSMUST00000032568
SMART Domains Protein: ENSMUSP00000032568
Gene: ENSMUSG00000030409

DomainStartEndE-ValueType
low complexity region 5 31 N/A INTRINSIC
S_TKc 71 339 6.5e-87 SMART
S_TK_X 340 407 3.6e-11 SMART
Pfam:DMPK_coil 472 532 2.8e-25 PFAM
low complexity region 590 613 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000049454
AA Change: V649L

PolyPhen 2 Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000045973
Gene: ENSMUSG00000040841
AA Change: V649L

DomainStartEndE-ValueType
coiled coil region 14 48 N/A INTRINSIC
Pfam:SIX1_SD 79 189 1.4e-43 PFAM
HOX 194 256 3.11e-14 SMART
low complexity region 300 313 N/A INTRINSIC
low complexity region 347 358 N/A INTRINSIC
low complexity region 429 442 N/A INTRINSIC
low complexity region 564 574 N/A INTRINSIC
low complexity region 620 639 N/A INTRINSIC
low complexity region 674 687 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108473
SMART Domains Protein: ENSMUSP00000104113
Gene: ENSMUSG00000030409

DomainStartEndE-ValueType
low complexity region 5 31 N/A INTRINSIC
S_TKc 71 339 1.36e-84 SMART
S_TK_X 340 407 7.5e-9 SMART
Pfam:DMPK_coil 472 532 2.2e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108474
SMART Domains Protein: ENSMUSP00000104114
Gene: ENSMUSG00000030409

DomainStartEndE-ValueType
low complexity region 5 31 N/A INTRINSIC
S_TKc 71 336 2.57e-76 SMART
Pfam:DMPK_coil 446 506 2.4e-28 PFAM
low complexity region 564 587 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126264
Predicted Effect probably benign
Transcript: ENSMUST00000127433
SMART Domains Protein: ENSMUSP00000115597
Gene: ENSMUSG00000085601

DomainStartEndE-ValueType
Blast:HLH 20 57 1e-17 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132115
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135839
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137219
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140742
Predicted Effect probably benign
Transcript: ENSMUST00000141380
SMART Domains Protein: ENSMUSP00000115575
Gene: ENSMUSG00000085601

DomainStartEndE-ValueType
HLH 20 74 6.84e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142725
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148380
Predicted Effect probably benign
Transcript: ENSMUST00000154199
SMART Domains Protein: ENSMUSP00000118459
Gene: ENSMUSG00000030409

DomainStartEndE-ValueType
low complexity region 5 31 N/A INTRINSIC
S_TKc 71 339 1.36e-84 SMART
S_TK_X 340 402 5.3e-9 SMART
Pfam:DMPK_coil 467 527 2.3e-28 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. [provided by RefSeq, Jul 2009]
PHENOTYPE: Homozygous null mutants exhibit a high incidence of progressive cataracts with background-dependent penetrance. Heterozygotes exhibit a similar phenotype, but with reduced incidence and severity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad10 T G 5: 121,631,570 M608L probably benign Het
Adamts2 A T 11: 50,788,700 M836L probably benign Het
Ankrd11 A T 8: 122,892,322 M1597K probably damaging Het
Arhgef17 A T 7: 100,883,882 F1145L possibly damaging Het
Atp13a3 A T 16: 30,333,796 W32R probably null Het
Atp2a3 C A 11: 72,975,339 H262N probably benign Het
Bod1l T A 5: 41,818,805 E1722V possibly damaging Het
Ceacam16 A G 7: 19,861,161 probably benign Het
Col14a1 T A 15: 55,420,862 Y840N unknown Het
Dlg5 A G 14: 24,191,182 C132R probably damaging Het
Dock4 T A 12: 40,668,430 N242K probably damaging Het
Dsg3 G A 18: 20,528,955 V426I probably benign Het
Dync1h1 T C 12: 110,659,272 probably benign Het
Flvcr2 T A 12: 85,796,223 M357K possibly damaging Het
Gapvd1 A G 2: 34,704,180 S932P probably damaging Het
Gata4 T A 14: 63,204,755 D205V possibly damaging Het
Gm5244 T C 19: 12,846,936 noncoding transcript Het
Kcnk2 T A 1: 189,258,779 I195L possibly damaging Het
Krt1 T C 15: 101,847,044 I427V probably benign Het
Mapk1ip1l T A 14: 47,310,882 H162Q possibly damaging Het
Micu1 A G 10: 59,839,736 D380G probably damaging Het
Mknk2 A C 10: 80,668,601 L289R probably damaging Het
Myo18a A T 11: 77,778,172 N286I possibly damaging Het
Olfr291 A T 7: 84,857,031 I221F probably damaging Het
Pdp1 C T 4: 11,962,062 R83H probably benign Het
Ptafr A C 4: 132,580,126 I276L probably benign Het
Rab3gap2 A T 1: 185,267,000 D968V possibly damaging Het
Samd8 T A 14: 21,793,144 M447K probably damaging Het
Slc1a2 T A 2: 102,739,880 F168I probably benign Het
Slc1a7 G A 4: 108,012,300 V521M possibly damaging Het
Soga1 A G 2: 157,040,743 V463A probably damaging Het
Sorbs1 T C 19: 40,365,133 D206G possibly damaging Het
Stim2 T C 5: 54,110,613 V417A probably damaging Het
Tbx20 A G 9: 24,773,713 probably benign Het
Tia1 A G 6: 86,416,390 I71V probably benign Het
Ttc7 T C 17: 87,340,899 S509P possibly damaging Het
Ttpal A G 2: 163,607,220 probably benign Het
Tubgcp2 A T 7: 139,996,154 N865K probably damaging Het
Wdr45 G T X: 7,727,049 E62* probably null Het
Zfp507 A G 7: 35,795,231 F129S probably damaging Het
Zfp518b T A 5: 38,674,155 H169L probably damaging Het
Other mutations in Six5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00975:Six5 APN 7 19097678 missense probably damaging 1.00
IGL01543:Six5 APN 7 19096347 missense possibly damaging 0.46
IGL03137:Six5 APN 7 19097147 unclassified probably benign
R0243:Six5 UTSW 7 19097022 splice site probably null
R0410:Six5 UTSW 7 19096456 missense probably damaging 1.00
R1942:Six5 UTSW 7 19096933 missense possibly damaging 0.68
R2055:Six5 UTSW 7 19095229 missense possibly damaging 0.78
R3726:Six5 UTSW 7 19096930 missense possibly damaging 0.86
R4801:Six5 UTSW 7 19096969 missense probably benign 0.19
R4802:Six5 UTSW 7 19096969 missense probably benign 0.19
R4898:Six5 UTSW 7 19095171 missense probably damaging 1.00
R6150:Six5 UTSW 7 19097521 missense probably benign 0.34
R6432:Six5 UTSW 7 19096771 missense probably damaging 1.00
R6667:Six5 UTSW 7 19096569 missense probably benign 0.00
R6736:Six5 UTSW 7 19094991 missense possibly damaging 0.83
R7101:Six5 UTSW 7 19094859 missense probably benign 0.01
R7253:Six5 UTSW 7 19094976 missense probably damaging 1.00
R7402:Six5 UTSW 7 19095043 missense probably damaging 1.00
R7719:Six5 UTSW 7 19096878 missense probably damaging 0.99
Posted On2015-04-16