Incidental Mutation 'IGL02643:Soga1'
ID301817
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Soga1
Ensembl Gene ENSMUSG00000055485
Gene Namesuppressor of glucose, autophagy associated 1
SynonymsD430036N24Rik, 9830001H06Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.233) question?
Stock #IGL02643
Quality Score
Status
Chromosome2
Chromosomal Location157015799-157079254 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 157040743 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 463 (V463A)
Ref Sequence ENSEMBL: ENSMUSP00000066556 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069098]
Predicted Effect probably damaging
Transcript: ENSMUST00000069098
AA Change: V463A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000066556
Gene: ENSMUSG00000055485
AA Change: V463A

DomainStartEndE-ValueType
low complexity region 15 23 N/A INTRINSIC
low complexity region 51 66 N/A INTRINSIC
low complexity region 97 112 N/A INTRINSIC
low complexity region 132 148 N/A INTRINSIC
low complexity region 155 174 N/A INTRINSIC
Blast:BRLZ 212 246 4e-8 BLAST
SCOP:d1fxkc_ 216 350 1e-3 SMART
Pfam:DUF3166 378 472 2.3e-31 PFAM
Pfam:DUF3166 504 593 5.3e-31 PFAM
low complexity region 637 649 N/A INTRINSIC
coiled coil region 807 867 N/A INTRINSIC
low complexity region 872 884 N/A INTRINSIC
low complexity region 938 950 N/A INTRINSIC
Pfam:DUF4482 1065 1205 3.9e-28 PFAM
low complexity region 1311 1321 N/A INTRINSIC
low complexity region 1363 1377 N/A INTRINSIC
low complexity region 1389 1418 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133571
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad10 T G 5: 121,631,570 M608L probably benign Het
Adamts2 A T 11: 50,788,700 M836L probably benign Het
Ankrd11 A T 8: 122,892,322 M1597K probably damaging Het
Arhgef17 A T 7: 100,883,882 F1145L possibly damaging Het
Atp13a3 A T 16: 30,333,796 W32R probably null Het
Atp2a3 C A 11: 72,975,339 H262N probably benign Het
Bod1l T A 5: 41,818,805 E1722V possibly damaging Het
Ceacam16 A G 7: 19,861,161 probably benign Het
Col14a1 T A 15: 55,420,862 Y840N unknown Het
Dlg5 A G 14: 24,191,182 C132R probably damaging Het
Dock4 T A 12: 40,668,430 N242K probably damaging Het
Dsg3 G A 18: 20,528,955 V426I probably benign Het
Dync1h1 T C 12: 110,659,272 probably benign Het
Flvcr2 T A 12: 85,796,223 M357K possibly damaging Het
Gapvd1 A G 2: 34,704,180 S932P probably damaging Het
Gata4 T A 14: 63,204,755 D205V possibly damaging Het
Gm5244 T C 19: 12,846,936 noncoding transcript Het
Kcnk2 T A 1: 189,258,779 I195L possibly damaging Het
Krt1 T C 15: 101,847,044 I427V probably benign Het
Mapk1ip1l T A 14: 47,310,882 H162Q possibly damaging Het
Micu1 A G 10: 59,839,736 D380G probably damaging Het
Mknk2 A C 10: 80,668,601 L289R probably damaging Het
Myo18a A T 11: 77,778,172 N286I possibly damaging Het
Olfr291 A T 7: 84,857,031 I221F probably damaging Het
Pdp1 C T 4: 11,962,062 R83H probably benign Het
Ptafr A C 4: 132,580,126 I276L probably benign Het
Rab3gap2 A T 1: 185,267,000 D968V possibly damaging Het
Samd8 T A 14: 21,793,144 M447K probably damaging Het
Six5 G T 7: 19,097,530 V649L probably benign Het
Slc1a2 T A 2: 102,739,880 F168I probably benign Het
Slc1a7 G A 4: 108,012,300 V521M possibly damaging Het
Sorbs1 T C 19: 40,365,133 D206G possibly damaging Het
Stim2 T C 5: 54,110,613 V417A probably damaging Het
Tbx20 A G 9: 24,773,713 probably benign Het
Tia1 A G 6: 86,416,390 I71V probably benign Het
Ttc7 T C 17: 87,340,899 S509P possibly damaging Het
Ttpal A G 2: 163,607,220 probably benign Het
Tubgcp2 A T 7: 139,996,154 N865K probably damaging Het
Wdr45 G T X: 7,727,049 E62* probably null Het
Zfp507 A G 7: 35,795,231 F129S probably damaging Het
Zfp518b T A 5: 38,674,155 H169L probably damaging Het
Other mutations in Soga1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Soga1 APN 2 157030864 missense probably damaging 1.00
IGL00924:Soga1 APN 2 157040705 missense probably damaging 0.99
IGL01723:Soga1 APN 2 157030614 missense probably benign 0.00
IGL01749:Soga1 APN 2 157021541 splice site probably benign
IGL02199:Soga1 APN 2 157030945 missense probably damaging 1.00
IGL02262:Soga1 APN 2 157030906 missense probably damaging 1.00
IGL02618:Soga1 APN 2 157040566 missense probably damaging 1.00
deglutition UTSW 2 157039864 missense possibly damaging 0.63
gulp UTSW 2 157023817 nonsense probably null
IGL02835:Soga1 UTSW 2 157041934 missense possibly damaging 0.91
R0528:Soga1 UTSW 2 157020692 missense probably damaging 1.00
R0535:Soga1 UTSW 2 157033289 missense possibly damaging 0.89
R0726:Soga1 UTSW 2 157060262 missense probably damaging 1.00
R1473:Soga1 UTSW 2 157020448 nonsense probably null
R1589:Soga1 UTSW 2 157027637 missense probably benign 0.05
R1615:Soga1 UTSW 2 157020743 missense probably damaging 1.00
R1681:Soga1 UTSW 2 157030530 missense possibly damaging 0.70
R1701:Soga1 UTSW 2 157030619 missense probably damaging 1.00
R1872:Soga1 UTSW 2 157040261 missense possibly damaging 0.88
R2056:Soga1 UTSW 2 157022827 missense probably benign 0.00
R2118:Soga1 UTSW 2 157033325 missense probably damaging 1.00
R2120:Soga1 UTSW 2 157033325 missense probably damaging 1.00
R2121:Soga1 UTSW 2 157033325 missense probably damaging 1.00
R2124:Soga1 UTSW 2 157033325 missense probably damaging 1.00
R2249:Soga1 UTSW 2 157040093 missense probably benign 0.08
R3147:Soga1 UTSW 2 157020364 missense possibly damaging 0.91
R3758:Soga1 UTSW 2 157020638 missense possibly damaging 0.77
R4601:Soga1 UTSW 2 157039924 missense probably benign 0.41
R4646:Soga1 UTSW 2 157020506 missense probably damaging 1.00
R4653:Soga1 UTSW 2 157040591 missense probably damaging 1.00
R4736:Soga1 UTSW 2 157020554 missense probably damaging 1.00
R4773:Soga1 UTSW 2 157030569 missense probably benign 0.08
R4796:Soga1 UTSW 2 157020252 missense probably benign
R4999:Soga1 UTSW 2 157022856 missense probably benign 0.10
R5304:Soga1 UTSW 2 157023817 nonsense probably null
R5369:Soga1 UTSW 2 157040734 missense probably damaging 1.00
R5530:Soga1 UTSW 2 157020342 missense probably damaging 1.00
R5712:Soga1 UTSW 2 157030921 missense probably damaging 1.00
R5780:Soga1 UTSW 2 157018490 missense probably damaging 0.98
R6162:Soga1 UTSW 2 157039864 missense possibly damaging 0.63
R6253:Soga1 UTSW 2 157021419 missense probably benign 0.00
R6303:Soga1 UTSW 2 157040764 missense possibly damaging 0.91
R6304:Soga1 UTSW 2 157040764 missense possibly damaging 0.91
R6523:Soga1 UTSW 2 157060343 nonsense probably null
R7216:Soga1 UTSW 2 157018370 missense possibly damaging 0.76
R7335:Soga1 UTSW 2 157031005 missense possibly damaging 0.86
R7562:Soga1 UTSW 2 157053589 missense probably damaging 1.00
X0019:Soga1 UTSW 2 157020264 missense probably benign 0.04
Posted On2015-04-16