Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02645:Zfp94'

301898

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp94

Ensembl Gene

ENSMUSG00000074282

Gene Name

zinc finger protein 94

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

IGL02645

Quality Score

Status

Chromosome

Chromosomal Location

24301704-24316666 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 24303754 bp

Zygosity

Heterozygous

Amino Acid Change

Glycine to Arginine at position 88 (G88R)

Ref Sequence

ENSEMBL: ENSMUSP00000104075 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032673] [ENSMUST00000077780] [ENSMUST00000108436] [ENSMUST00000145131]

Predicted Effect

probably benign
Transcript: ENSMUST00000032673
AA Change: G82R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000032673
Gene: ENSMUSG00000074282
AA Change: G82R

Domain	Start	End	E-Value	Type
KRAB	2	59	3.06e-19	SMART
ZnF_C2H2	157	179	5.06e-2	SMART
ZnF_C2H2	185	207	8.47e-4	SMART
ZnF_C2H2	213	235	4.72e-2	SMART
ZnF_C2H2	241	263	1.28e-3	SMART
ZnF_C2H2	269	291	5.21e-4	SMART
ZnF_C2H2	297	319	9.08e-4	SMART
ZnF_C2H2	325	347	2.09e-3	SMART
ZnF_C2H2	353	375	8.94e-3	SMART
ZnF_C2H2	381	403	2.4e-3	SMART
ZnF_C2H2	409	431	8.6e-5	SMART
ZnF_C2H2	437	459	7.9e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000077780

SMART Domains

Protein: ENSMUSP00000076954
Gene: ENSMUSG00000050605

Domain	Start	End	E-Value	Type
KRAB	4	63	2.28e-27	SMART
ZnF_C2H2	311	333	1.4e-4	SMART
ZnF_C2H2	339	361	5.5e-3	SMART
ZnF_C2H2	367	389	2.99e-4	SMART
ZnF_C2H2	395	417	1.18e-2	SMART
ZnF_C2H2	423	445	2.4e-3	SMART
ZnF_C2H2	451	473	2.95e-3	SMART
ZnF_C2H2	479	501	9.88e-5	SMART
ZnF_C2H2	507	529	1.5e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108436
AA Change: G88R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000104075
Gene: ENSMUSG00000074282
AA Change: G88R

Domain	Start	End	E-Value	Type
KRAB	8	65	3.06e-19	SMART
ZnF_C2H2	163	185	5.06e-2	SMART
ZnF_C2H2	191	213	8.47e-4	SMART
ZnF_C2H2	219	241	4.72e-2	SMART
ZnF_C2H2	247	269	1.28e-3	SMART
ZnF_C2H2	275	297	5.21e-4	SMART
ZnF_C2H2	303	325	9.08e-4	SMART
ZnF_C2H2	331	353	2.09e-3	SMART
ZnF_C2H2	359	381	8.94e-3	SMART
ZnF_C2H2	387	409	2.4e-3	SMART
ZnF_C2H2	415	437	8.6e-5	SMART
ZnF_C2H2	443	465	7.9e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128421

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137781

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138619

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139811

Predicted Effect

probably benign
Transcript: ENSMUST00000145131

SMART Domains

Protein: ENSMUSP00000117077
Gene: ENSMUSG00000050605

Domain	Start	End	E-Value	Type
KRAB	4	64	4.63e-19	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146817

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206535

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110017D15Rik	A	G	4: 41,517,080	V28A	probably damaging	Het
Ang4	T	C	14: 51,764,347	Y48C	probably damaging	Het
Aox2	T	A	1: 58,334,724	M848K	probably damaging	Het
Apol7c	A	T	15: 77,528,883	S56T	probably benign	Het
Asic4	G	A	1: 75,473,354		probably benign	Het
Asxl1	A	G	2: 153,392,857	K162R	possibly damaging	Het
BC053393	A	G	11: 46,586,220	R167G	probably benign	Het
Car12	T	A	9: 66,747,679	H130Q	probably benign	Het
Cars	T	C	7: 143,557,909	E737G	probably damaging	Het
Ccdc141	G	A	2: 77,074,867	R412*	probably null	Het
Cd36	T	C	5: 17,785,880	T421A	probably benign	Het
Clasp2	T	G	9: 113,890,061	M758R	probably damaging	Het
Dock10	T	A	1: 80,574,123	Y665F	probably damaging	Het
Ebf4	A	G	2: 130,361,841	K471E	probably damaging	Het
Fat2	T	A	11: 55,282,828	D2353V	probably damaging	Het
Gm10136	A	G	19: 29,003,740		probably benign	Het
Intu	A	G	3: 40,701,272	I930V	probably benign	Het
Ndrg2	T	A	14: 51,906,522	M300L	possibly damaging	Het
Nhs	A	G	X: 162,159,058	S111P	probably benign	Het
Nme8	T	A	13: 19,660,585	L111F	probably damaging	Het
Nol8	T	A	13: 49,665,471		probably null	Het
Olfr1148	C	T	2: 87,833,615	T192M	probably benign	Het
Olfr1221	T	C	2: 89,111,619	R298G	probably benign	Het
Olfr1249	T	C	2: 89,630,335	T188A	probably benign	Het
Olfr1511	T	A	14: 52,390,501	T91S	possibly damaging	Het
Pcdhac2	G	A	18: 37,145,239	G424D	probably damaging	Het
Pex3	T	G	10: 13,546,429	E42D	possibly damaging	Het
Plxnb1	C	T	9: 109,114,243		probably benign	Het
Rpe65	T	A	3: 159,606,491	I209N	probably damaging	Het
Rsl1	T	A	13: 67,182,209	F240L	probably benign	Het
Rttn	A	T	18: 89,110,686	I1921F	probably benign	Het
Scn3a	A	T	2: 65,514,527	F539Y	probably benign	Het
Secisbp2	T	A	13: 51,682,460	M767K	probably damaging	Het
Sipa1l3	C	T	7: 29,328,980		probably null	Het
Slfn8	T	C	11: 83,003,554	N753S	possibly damaging	Het
Sympk	T	G	7: 19,052,424	V984G	probably damaging	Het
Tacr3	A	T	3: 134,861,182	D272V	possibly damaging	Het
Tnpo3	G	T	6: 29,562,900	S606*	probably null	Het
Zfp804a	T	C	2: 82,053,876	L29P	possibly damaging	Het

Other mutations in Zfp94

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01755:Zfp94	APN	7	24311481	utr 5 prime	probably benign
R0684:Zfp94	UTSW	7	24303070	missense	probably damaging	1.00
R1177:Zfp94	UTSW	7	24303528	missense	probably damaging	1.00
R1644:Zfp94	UTSW	7	24311502	splice site	probably benign
R1675:Zfp94	UTSW	7	24302834	missense	probably damaging	1.00
R1826:Zfp94	UTSW	7	24309115	missense	probably damaging	1.00
R1861:Zfp94	UTSW	7	24309116	missense	probably damaging	1.00
R3932:Zfp94	UTSW	7	24303687	missense	probably benign	0.06
R4912:Zfp94	UTSW	7	24303741	missense	probably benign	0.05
R5663:Zfp94	UTSW	7	24302827	missense	probably damaging	1.00
R6539:Zfp94	UTSW	7	24303291	missense	probably damaging	1.00
R7023:Zfp94	UTSW	7	24303396	missense	probably damaging	1.00
R7710:Zfp94	UTSW	7	24303682	missense	probably benign
R7810:Zfp94	UTSW	7	24303073	missense	probably benign	0.00
Z1176:Zfp94	UTSW	7	24303811	missense	not run

Posted On

2015-04-16