Incidental Mutation 'IGL02645:Ang4'
ID301909
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ang4
Ensembl Gene ENSMUSG00000060615
Gene Nameangiogenin, ribonuclease A family, member 4
SynonymsRnase5d
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock #IGL02645
Quality Score
Status
Chromosome14
Chromosomal Location51763878-51773590 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 51764347 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 48 (Y48C)
Ref Sequence ENSEMBL: ENSMUSP00000073525 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073860]
PDB Structure
Biological and Structural Features of Murine Angiogenin-4, an Angiogenic Protein [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000073860
AA Change: Y48C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073525
Gene: ENSMUSG00000060615
AA Change: Y48C

DomainStartEndE-ValueType
low complexity region 5 21 N/A INTRINSIC
RNAse_Pc 25 141 5.34e-61 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110017D15Rik A G 4: 41,517,080 V28A probably damaging Het
Aox2 T A 1: 58,334,724 M848K probably damaging Het
Apol7c A T 15: 77,528,883 S56T probably benign Het
Asic4 G A 1: 75,473,354 probably benign Het
Asxl1 A G 2: 153,392,857 K162R possibly damaging Het
BC053393 A G 11: 46,586,220 R167G probably benign Het
Car12 T A 9: 66,747,679 H130Q probably benign Het
Cars T C 7: 143,557,909 E737G probably damaging Het
Ccdc141 G A 2: 77,074,867 R412* probably null Het
Cd36 T C 5: 17,785,880 T421A probably benign Het
Clasp2 T G 9: 113,890,061 M758R probably damaging Het
Dock10 T A 1: 80,574,123 Y665F probably damaging Het
Ebf4 A G 2: 130,361,841 K471E probably damaging Het
Fat2 T A 11: 55,282,828 D2353V probably damaging Het
Gm10136 A G 19: 29,003,740 probably benign Het
Intu A G 3: 40,701,272 I930V probably benign Het
Ndrg2 T A 14: 51,906,522 M300L possibly damaging Het
Nhs A G X: 162,159,058 S111P probably benign Het
Nme8 T A 13: 19,660,585 L111F probably damaging Het
Nol8 T A 13: 49,665,471 probably null Het
Olfr1148 C T 2: 87,833,615 T192M probably benign Het
Olfr1221 T C 2: 89,111,619 R298G probably benign Het
Olfr1249 T C 2: 89,630,335 T188A probably benign Het
Olfr1511 T A 14: 52,390,501 T91S possibly damaging Het
Pcdhac2 G A 18: 37,145,239 G424D probably damaging Het
Pex3 T G 10: 13,546,429 E42D possibly damaging Het
Plxnb1 C T 9: 109,114,243 probably benign Het
Rpe65 T A 3: 159,606,491 I209N probably damaging Het
Rsl1 T A 13: 67,182,209 F240L probably benign Het
Rttn A T 18: 89,110,686 I1921F probably benign Het
Scn3a A T 2: 65,514,527 F539Y probably benign Het
Secisbp2 T A 13: 51,682,460 M767K probably damaging Het
Sipa1l3 C T 7: 29,328,980 probably null Het
Slfn8 T C 11: 83,003,554 N753S possibly damaging Het
Sympk T G 7: 19,052,424 V984G probably damaging Het
Tacr3 A T 3: 134,861,182 D272V possibly damaging Het
Tnpo3 G T 6: 29,562,900 S606* probably null Het
Zfp804a T C 2: 82,053,876 L29P possibly damaging Het
Zfp94 C T 7: 24,303,754 G88R probably benign Het
Other mutations in Ang4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01363:Ang4 APN 14 51764179 missense probably benign 0.11
IGL01393:Ang4 APN 14 51764213 missense probably benign 0.00
IGL02023:Ang4 APN 14 51764054 utr 3 prime probably benign
R0023:Ang4 UTSW 14 51764403 nonsense probably null
R0834:Ang4 UTSW 14 51764268 missense probably benign
R1076:Ang4 UTSW 14 51764302 missense probably damaging 1.00
R2258:Ang4 UTSW 14 51764498 start gained probably benign
R4524:Ang4 UTSW 14 51764148 nonsense probably null
R4981:Ang4 UTSW 14 51764372 missense probably benign 0.11
R5929:Ang4 UTSW 14 51764251 missense probably damaging 1.00
R7840:Ang4 UTSW 14 51764072 missense probably damaging 1.00
Z1176:Ang4 UTSW 14 51764148 nonsense probably null
Posted On2015-04-16