Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02645:Zfp804a'

301924

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp804a

Ensembl Gene

ENSMUSG00000070866

Gene Name

zinc finger protein 804A

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.227) question?

Stock #

IGL02645

Quality Score

Status

Chromosome

Chromosomal Location

82053222-82259879 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 82053876 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 29 (L29P)

Ref Sequence

ENSEMBL: ENSMUSP00000041941 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047527]

AlphaFold

A2AKY4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000047527
AA Change: L29P

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000041941
Gene: ENSMUSG00000070866
AA Change: L29P

Domain	Start	End	E-Value	Type
ZnF_C2H2	57	81	7.29e0	SMART
low complexity region	588	595	N/A	INTRINSIC
low complexity region	801	808	N/A	INTRINSIC
low complexity region	1012	1029	N/A	INTRINSIC
low complexity region	1061	1077	N/A	INTRINSIC
low complexity region	1168	1191	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a zinc finger binding protein. Polymorphisms in this gene, especially rs1344706, are thought to confer increased susceptibility to schizophrenia, bipolar disorder, and heroin addiciton. [provided by RefSeq, Nov 2015]

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110017D15Rik	A	G	4: 41,517,080	V28A	probably damaging	Het
Ang4	T	C	14: 51,764,347	Y48C	probably damaging	Het
Aox2	T	A	1: 58,334,724	M848K	probably damaging	Het
Apol7c	A	T	15: 77,528,883	S56T	probably benign	Het
Asic4	G	A	1: 75,473,354		probably benign	Het
Asxl1	A	G	2: 153,392,857	K162R	possibly damaging	Het
BC053393	A	G	11: 46,586,220	R167G	probably benign	Het
Car12	T	A	9: 66,747,679	H130Q	probably benign	Het
Cars	T	C	7: 143,557,909	E737G	probably damaging	Het
Ccdc141	G	A	2: 77,074,867	R412*	probably null	Het
Cd36	T	C	5: 17,785,880	T421A	probably benign	Het
Clasp2	T	G	9: 113,890,061	M758R	probably damaging	Het
Dock10	T	A	1: 80,574,123	Y665F	probably damaging	Het
Ebf4	A	G	2: 130,361,841	K471E	probably damaging	Het
Fat2	T	A	11: 55,282,828	D2353V	probably damaging	Het
Gm10136	A	G	19: 29,003,740		probably benign	Het
Intu	A	G	3: 40,701,272	I930V	probably benign	Het
Ndrg2	T	A	14: 51,906,522	M300L	possibly damaging	Het
Nhs	A	G	X: 162,159,058	S111P	probably benign	Het
Nme8	T	A	13: 19,660,585	L111F	probably damaging	Het
Nol8	T	A	13: 49,665,471		probably null	Het
Olfr1148	C	T	2: 87,833,615	T192M	probably benign	Het
Olfr1221	T	C	2: 89,111,619	R298G	probably benign	Het
Olfr1249	T	C	2: 89,630,335	T188A	probably benign	Het
Olfr1511	T	A	14: 52,390,501	T91S	possibly damaging	Het
Pcdhac2	G	A	18: 37,145,239	G424D	probably damaging	Het
Pex3	T	G	10: 13,546,429	E42D	possibly damaging	Het
Plxnb1	C	T	9: 109,114,243		probably benign	Het
Rpe65	T	A	3: 159,606,491	I209N	probably damaging	Het
Rsl1	T	A	13: 67,182,209	F240L	probably benign	Het
Rttn	A	T	18: 89,110,686	I1921F	probably benign	Het
Scn3a	A	T	2: 65,514,527	F539Y	probably benign	Het
Secisbp2	T	A	13: 51,682,460	M767K	probably damaging	Het
Sipa1l3	C	T	7: 29,328,980		probably null	Het
Slfn8	T	C	11: 83,003,554	N753S	possibly damaging	Het
Sympk	T	G	7: 19,052,424	V984G	probably damaging	Het
Tacr3	A	T	3: 134,861,182	D272V	possibly damaging	Het
Tnpo3	G	T	6: 29,562,900	S606*	probably null	Het
Zfp94	C	T	7: 24,303,754	G88R	probably benign	Het

Other mutations in Zfp804a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00466:Zfp804a	APN	2	82053875	missense	probably benign	0.30
IGL02011:Zfp804a	APN	2	82256691	missense	probably damaging	1.00
IGL02218:Zfp804a	APN	2	82259202	missense	probably damaging	1.00
PIT4431001:Zfp804a	UTSW	2	82259192	missense	probably benign	0.04
R0027:Zfp804a	UTSW	2	82257200	missense	probably damaging	1.00
R0167:Zfp804a	UTSW	2	82256516	missense	probably damaging	1.00
R0437:Zfp804a	UTSW	2	82053791	start codon destroyed	probably null	0.08
R0521:Zfp804a	UTSW	2	82259417	nonsense	probably null
R0546:Zfp804a	UTSW	2	82258920	missense	possibly damaging	0.91
R0609:Zfp804a	UTSW	2	82257588	missense	probably damaging	1.00
R0694:Zfp804a	UTSW	2	82053804	missense	probably damaging	1.00
R0837:Zfp804a	UTSW	2	82259162	missense	probably damaging	1.00
R0947:Zfp804a	UTSW	2	82258718	missense	possibly damaging	0.58
R1103:Zfp804a	UTSW	2	82257500	missense	probably damaging	0.99
R1168:Zfp804a	UTSW	2	82256697	missense	probably benign	0.43
R1365:Zfp804a	UTSW	2	82257246	missense	probably benign	0.00
R1377:Zfp804a	UTSW	2	82258497	missense	probably benign	0.39
R1501:Zfp804a	UTSW	2	82235799	missense	probably damaging	1.00
R1526:Zfp804a	UTSW	2	82258188	missense	probably benign
R1585:Zfp804a	UTSW	2	82053751	start gained	probably benign
R1674:Zfp804a	UTSW	2	82258824	missense	probably benign	0.35
R2058:Zfp804a	UTSW	2	82257366	missense	probably benign	0.00
R2146:Zfp804a	UTSW	2	82258664	missense	probably benign	0.02
R2149:Zfp804a	UTSW	2	82258664	missense	probably benign	0.02
R2171:Zfp804a	UTSW	2	82257183	missense	possibly damaging	0.77
R2307:Zfp804a	UTSW	2	82256857	missense	probably benign	0.04
R2398:Zfp804a	UTSW	2	82258669	missense	possibly damaging	0.95
R2496:Zfp804a	UTSW	2	82235844	missense	probably damaging	1.00
R2504:Zfp804a	UTSW	2	82257519	missense	probably benign	0.00
R2919:Zfp804a	UTSW	2	82235816	missense	probably damaging	1.00
R2943:Zfp804a	UTSW	2	82235879	missense	probably damaging	1.00
R3116:Zfp804a	UTSW	2	82259417	missense	probably damaging	1.00
R4170:Zfp804a	UTSW	2	82253488	missense	probably damaging	1.00
R4393:Zfp804a	UTSW	2	82256921	missense	probably benign	0.43
R4701:Zfp804a	UTSW	2	82256582	missense	probably damaging	1.00
R4771:Zfp804a	UTSW	2	82257942	missense	probably benign	0.01
R4793:Zfp804a	UTSW	2	82235842	missense	probably damaging	1.00
R5523:Zfp804a	UTSW	2	82258995	missense	probably damaging	1.00
R5526:Zfp804a	UTSW	2	82258590	missense	probably benign	0.00
R5961:Zfp804a	UTSW	2	82258002	missense	probably benign
R6181:Zfp804a	UTSW	2	82257142	missense	probably damaging	1.00
R6209:Zfp804a	UTSW	2	82258118	missense	probably damaging	1.00
R6325:Zfp804a	UTSW	2	82257038	missense	possibly damaging	0.80
R7147:Zfp804a	UTSW	2	82258187	missense	probably benign	0.00
R7229:Zfp804a	UTSW	2	82258625	missense	probably benign	0.04
R7666:Zfp804a	UTSW	2	82259060	nonsense	probably null
R7910:Zfp804a	UTSW	2	82256573	missense	probably damaging	1.00
R8256:Zfp804a	UTSW	2	82053849	missense	probably damaging	0.99
R8669:Zfp804a	UTSW	2	82257762	missense	probably damaging	1.00
R8738:Zfp804a	UTSW	2	82259106	missense	probably damaging	1.00
R8749:Zfp804a	UTSW	2	82257575	missense	probably benign	0.18
R8751:Zfp804a	UTSW	2	82235846	missense	probably damaging	0.96
R8828:Zfp804a	UTSW	2	82259115	missense	possibly damaging	0.74
R8834:Zfp804a	UTSW	2	82259097	missense	possibly damaging	0.76
R8924:Zfp804a	UTSW	2	82258403	missense	probably benign	0.03
R8982:Zfp804a	UTSW	2	82235828	missense	probably damaging	1.00
R9459:Zfp804a	UTSW	2	82259409	missense	probably damaging	1.00
R9570:Zfp804a	UTSW	2	82258500	missense	probably benign	0.22
X0064:Zfp804a	UTSW	2	82235823	missense	probably damaging	1.00
Z1177:Zfp804a	UTSW	2	82258563	missense	probably benign	0.25

Posted On

2015-04-16