Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02647:Zfp981'

301999

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp981

Ensembl Gene

ENSMUSG00000056300

Gene Name

zinc finger protein 981

Synonyms

Gm13247

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

IGL02647

Quality Score

Status

Chromosome

Chromosomal Location

146586484-146623852 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 146621709 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 211 (Y211*)

Ref Sequence

ENSEMBL: ENSMUSP00000136739 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105735] [ENSMUST00000140089] [ENSMUST00000179175]

AlphaFold

A2A8V7

Predicted Effect

probably null
Transcript: ENSMUST00000105735
AA Change: Y211*

SMART Domains

Protein: ENSMUSP00000101361
Gene: ENSMUSG00000056300
AA Change: Y211*

Domain	Start	End	E-Value	Type
KRAB	13	73	2.34e-15	SMART
ZnF_C2H2	239	261	7.9e-4	SMART
ZnF_C2H2	267	289	8.6e-5	SMART
ZnF_C2H2	295	317	8.6e-5	SMART
ZnF_C2H2	323	345	1.36e-2	SMART
ZnF_C2H2	351	373	6.32e-3	SMART
ZnF_C2H2	379	401	8.6e-5	SMART
ZnF_C2H2	407	429	3.11e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000140089

SMART Domains

Protein: ENSMUSP00000115886
Gene: ENSMUSG00000056300

Domain	Start	End	E-Value	Type
KRAB	13	73	2.34e-15	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145269

Predicted Effect

probably null
Transcript: ENSMUST00000179175
AA Change: Y211*

SMART Domains

Protein: ENSMUSP00000136739
Gene: ENSMUSG00000056300
AA Change: Y211*

Domain	Start	End	E-Value	Type
KRAB	13	73	2.34e-15	SMART
ZnF_C2H2	239	261	7.9e-4	SMART
ZnF_C2H2	267	289	8.6e-5	SMART
ZnF_C2H2	295	317	8.6e-5	SMART
ZnF_C2H2	323	345	1.36e-2	SMART
ZnF_C2H2	351	373	6.32e-3	SMART
ZnF_C2H2	379	401	8.6e-5	SMART
ZnF_C2H2	407	429	3.11e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181199

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actr8	A	T	14: 29,712,847 (GRCm39)	R497W	probably damaging	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Bmx	T	C	X: 162,988,231 (GRCm39)	E495G	probably damaging	Het
Cbx5	T	C	15: 103,109,330 (GRCm39)		probably null	Het
Cenpj	C	T	14: 56,767,536 (GRCm39)	V1203M	probably damaging	Het
Ces1b	T	C	8: 93,783,672 (GRCm39)	H516R	probably benign	Het
D430041D05Rik	T	C	2: 104,078,611 (GRCm39)	N1235S	probably damaging	Het
Depdc1a	A	T	3: 159,228,503 (GRCm39)	K418N	probably damaging	Het
Dysf	G	A	6: 84,114,355 (GRCm39)	V1215M	probably damaging	Het
Flacc1	T	C	1: 58,709,613 (GRCm39)	T181A	probably benign	Het
Foxf2	A	T	13: 31,811,218 (GRCm39)	N386Y	probably damaging	Het
Frem1	A	T	4: 82,919,991 (GRCm39)	V455E	probably damaging	Het
Fzd7	C	A	1: 59,523,554 (GRCm39)	P479Q	probably damaging	Het
Hnmt	G	A	2: 23,904,319 (GRCm39)	S114F	possibly damaging	Het
Irf3	A	G	7: 44,649,800 (GRCm39)	N6S	probably benign	Het
Krt26	C	T	11: 99,224,471 (GRCm39)	R349Q	probably benign	Het
Lrba	A	G	3: 86,267,038 (GRCm39)	D1576G	probably benign	Het
Lsg1	A	T	16: 30,404,370 (GRCm39)		probably null	Het
Mal2	T	C	15: 54,451,833 (GRCm39)	F85L	probably damaging	Het
Me2	A	C	18: 73,930,974 (GRCm39)	S106R	probably benign	Het
Med21	T	C	6: 146,550,731 (GRCm39)	S81P	probably benign	Het
Mos	T	C	4: 3,870,961 (GRCm39)	Y285C	probably damaging	Het
Mtmr1	A	G	X: 70,436,939 (GRCm39)	N256S	probably damaging	Het
Or7e174	T	A	9: 20,012,505 (GRCm39)	M150K	probably benign	Het
Prl3d2	A	C	13: 27,309,999 (GRCm39)	T155P	probably benign	Het
R3hdm2	C	T	10: 127,295,353 (GRCm39)	S240L	probably damaging	Het
Semp2l2a	T	C	8: 13,886,979 (GRCm39)	T371A	probably damaging	Het
Skint6	A	T	4: 112,985,088 (GRCm39)		probably benign	Het
Ubr5	A	G	15: 37,992,326 (GRCm39)	S1933P	probably damaging	Het
Veph1	A	T	3: 66,066,869 (GRCm39)		probably benign	Het
Xpo7	A	G	14: 70,922,905 (GRCm39)	F557S	probably damaging	Het
Zfp647	T	C	15: 76,801,915 (GRCm39)	E30G	probably damaging	Het
Zfp655	A	T	5: 145,179,816 (GRCm39)	I75L	probably benign	Het

Other mutations in Zfp981

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0003:Zfp981	UTSW	4	146,622,217 (GRCm39)	missense	probably damaging	1.00
R1172:Zfp981	UTSW	4	146,622,221 (GRCm39)	missense	probably benign
R2989:Zfp981	UTSW	4	146,622,347 (GRCm39)	missense	probably benign	0.40
R4158:Zfp981	UTSW	4	146,622,339 (GRCm39)	missense	probably benign	0.07
R4158:Zfp981	UTSW	4	146,622,080 (GRCm39)	missense	probably benign
R4778:Zfp981	UTSW	4	146,622,112 (GRCm39)	missense	probably benign
R5148:Zfp981	UTSW	4	146,621,357 (GRCm39)	missense	possibly damaging	0.86
R5352:Zfp981	UTSW	4	146,621,462 (GRCm39)	missense	probably benign	0.29
R6252:Zfp981	UTSW	4	146,621,970 (GRCm39)	missense	probably benign	0.22
R6674:Zfp981	UTSW	4	146,619,950 (GRCm39)	missense	probably damaging	0.98
R6765:Zfp981	UTSW	4	146,622,363 (GRCm39)	missense	probably benign	0.34
R7288:Zfp981	UTSW	4	146,622,100 (GRCm39)	missense	probably benign	0.32
R7816:Zfp981	UTSW	4	146,622,100 (GRCm39)	missense	probably benign	0.32
R7835:Zfp981	UTSW	4	146,622,333 (GRCm39)	missense	probably benign	0.01
R8020:Zfp981	UTSW	4	146,621,825 (GRCm39)	missense	possibly damaging	0.91
R8797:Zfp981	UTSW	4	146,619,906 (GRCm39)	nonsense	probably null
R8805:Zfp981	UTSW	4	146,622,410 (GRCm39)	missense	possibly damaging	0.86
R9145:Zfp981	UTSW	4	146,622,410 (GRCm39)	missense	possibly damaging	0.72
R9324:Zfp981	UTSW	4	146,619,884 (GRCm39)	missense	possibly damaging	0.95
R9471:Zfp981	UTSW	4	146,622,080 (GRCm39)	missense	probably benign
Z1176:Zfp981	UTSW	4	146,621,547 (GRCm39)	missense	probably damaging	0.96

Posted On

2015-04-16