Incidental Mutation 'IGL02648:Prl2c1'
ID302007
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl2c1
Ensembl Gene ENSMUSG00000062551
Gene NameProlactin family 2, subfamily c, member 1
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL02648
Quality Score
Status
Chromosome13
Chromosomal Location27849342-27857788 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 27857559 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 188 (D188G)
Ref Sequence ENSEMBL: ENSMUSP00000105964 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054932] [ENSMUST00000110335]
Predicted Effect probably benign
Transcript: ENSMUST00000054932
AA Change: D186G

PolyPhen 2 Score 0.301 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000053446
Gene: ENSMUSG00000062551
AA Change: D186G

DomainStartEndE-ValueType
Pfam:Hormone_1 16 226 1.8e-73 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079228
AA Change: D152G

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000078221
Gene: ENSMUSG00000062551
AA Change: D152G

DomainStartEndE-ValueType
Pfam:Hormone_1 16 72 7.1e-14 PFAM
Pfam:Hormone_1 70 192 4.1e-41 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110335
AA Change: D188G

PolyPhen 2 Score 0.435 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000105964
Gene: ENSMUSG00000062551
AA Change: D188G

DomainStartEndE-ValueType
Pfam:Hormone_1 16 228 1.9e-77 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 A T 4: 144,617,822 probably null Het
Acp4 A G 7: 44,254,990 probably benign Het
Adgrv1 A T 13: 81,511,619 M1997K probably benign Het
Arhgdib T C 6: 136,933,649 D38G probably damaging Het
Bbox1 T G 2: 110,305,526 D36A probably damaging Het
Cacna1c T C 6: 118,757,496 K104R probably damaging Het
Cacna1i G A 15: 80,298,638 C75Y probably damaging Het
Ccdc14 T C 16: 34,697,158 L70S probably damaging Het
Ccdc88a T G 11: 29,501,051 V1580G probably benign Het
Cdadc1 C A 14: 59,586,363 D227Y probably damaging Het
Chd3 T C 11: 69,352,150 Y1415C probably damaging Het
Cngb3 A G 4: 19,428,489 N493S probably benign Het
Dock10 T A 1: 80,574,123 Y665F probably damaging Het
Gm10549 C A 18: 33,464,250 probably benign Het
Gm17677 A T 9: 35,741,109 M21L probably benign Het
Greb1 C T 12: 16,708,682 V678M probably damaging Het
Gucy2c G A 6: 136,729,213 R497* probably null Het
Itgad T C 7: 128,183,374 probably benign Het
Lgr4 C A 2: 110,012,373 T877K probably damaging Het
Lrig3 A G 10: 125,966,594 D40G probably benign Het
Myo3b T C 2: 70,105,372 probably benign Het
Neb A G 2: 52,271,081 Y2193H possibly damaging Het
Olfr1270 T A 2: 90,149,353 I218F possibly damaging Het
Olfr918 T C 9: 38,673,016 M143V probably benign Het
Pard6b A G 2: 168,098,927 Q278R probably benign Het
Pkd2l1 T C 19: 44,155,536 Y366C possibly damaging Het
Prl3a1 G T 13: 27,270,235 M65I probably benign Het
Psg26 T A 7: 18,482,766 E49D probably benign Het
Rapgef3 G A 15: 97,758,392 R38W probably damaging Het
Rrn3 T C 16: 13,811,589 F590L probably benign Het
Serpina12 T C 12: 104,038,008 K122E probably benign Het
Slc39a6 T C 18: 24,582,367 I699V probably damaging Het
Tmem259 G A 10: 79,977,817 P443S probably damaging Het
Vmn1r75 T A 7: 11,881,164 F274L probably benign Het
Other mutations in Prl2c1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02630:Prl2c1 APN 13 27857497 splice site probably benign
IGL02823:Prl2c1 APN 13 27856433 splice site probably benign
IGL03024:Prl2c1 APN 13 27856541 missense probably benign 0.22
IGL03229:Prl2c1 APN 13 27856629 splice site probably benign
R4739:Prl2c1 UTSW 13 27857678 missense probably damaging 1.00
R4978:Prl2c1 UTSW 13 27857570 missense probably benign 0.00
R6860:Prl2c1 UTSW 13 27851741 missense probably benign 0.31
R7719:Prl2c1 UTSW 13 27851797 missense probably damaging 1.00
Posted On2015-04-16