Incidental Mutation 'IGL02648:Prl3a1'
ID 302026
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl3a1
Ensembl Gene ENSMUSG00000038883
Gene Name prolactin family 3, subfamily a, member 1
Synonyms Prlpi, PLP-I, 1600016E11Rik, PLP-H, Plpi
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # IGL02648
Quality Score
Status
Chromosome 13
Chromosomal Location 27443472-27460669 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 27454218 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 65 (M65I)
Ref Sequence ENSEMBL: ENSMUSP00000046522 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049463]
AlphaFold Q78Y73
Predicted Effect probably benign
Transcript: ENSMUST00000049463
AA Change: M65I

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000046522
Gene: ENSMUSG00000038883
AA Change: M65I

DomainStartEndE-ValueType
Pfam:Hormone_1 16 227 2.3e-59 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223739
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 A T 4: 144,344,392 (GRCm39) probably null Het
Acp4 A G 7: 43,904,414 (GRCm39) probably benign Het
Adgrv1 A T 13: 81,659,738 (GRCm39) M1997K probably benign Het
Arhgdib T C 6: 136,910,647 (GRCm39) D38G probably damaging Het
Bbox1 T G 2: 110,135,871 (GRCm39) D36A probably damaging Het
Cacna1c T C 6: 118,734,457 (GRCm39) K104R probably damaging Het
Cacna1i G A 15: 80,182,839 (GRCm39) C75Y probably damaging Het
Ccdc14 T C 16: 34,517,528 (GRCm39) L70S probably damaging Het
Ccdc88a T G 11: 29,451,051 (GRCm39) V1580G probably benign Het
Cdadc1 C A 14: 59,823,812 (GRCm39) D227Y probably damaging Het
Chd3 T C 11: 69,242,976 (GRCm39) Y1415C probably damaging Het
Cngb3 A G 4: 19,428,489 (GRCm39) N493S probably benign Het
Dock10 T A 1: 80,551,840 (GRCm39) Y665F probably damaging Het
Gm10549 C A 18: 33,597,303 (GRCm39) probably benign Het
Greb1 C T 12: 16,758,683 (GRCm39) V678M probably damaging Het
Gucy2c G A 6: 136,706,211 (GRCm39) R497* probably null Het
Itgad T C 7: 127,782,546 (GRCm39) probably benign Het
Lgr4 C A 2: 109,842,718 (GRCm39) T877K probably damaging Het
Lrig3 A G 10: 125,802,463 (GRCm39) D40G probably benign Het
Myo3b T C 2: 69,935,716 (GRCm39) probably benign Het
Neb A G 2: 52,161,093 (GRCm39) Y2193H possibly damaging Het
Or4b1 T A 2: 89,979,697 (GRCm39) I218F possibly damaging Het
Or8b3b T C 9: 38,584,312 (GRCm39) M143V probably benign Het
Pard6b A G 2: 167,940,847 (GRCm39) Q278R probably benign Het
Pate10 A T 9: 35,652,405 (GRCm39) M21L probably benign Het
Pkd2l1 T C 19: 44,143,975 (GRCm39) Y366C possibly damaging Het
Prl2c1 A G 13: 28,041,542 (GRCm39) D188G probably benign Het
Psg26 T A 7: 18,216,691 (GRCm39) E49D probably benign Het
Rapgef3 G A 15: 97,656,273 (GRCm39) R38W probably damaging Het
Rrn3 T C 16: 13,629,453 (GRCm39) F590L probably benign Het
Serpina12 T C 12: 104,004,267 (GRCm39) K122E probably benign Het
Slc39a6 T C 18: 24,715,424 (GRCm39) I699V probably damaging Het
Tmem259 G A 10: 79,813,651 (GRCm39) P443S probably damaging Het
Vmn1r75 T A 7: 11,615,091 (GRCm39) F274L probably benign Het
Other mutations in Prl3a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02216:Prl3a1 APN 13 27,454,127 (GRCm39) missense probably benign 0.13
R1405:Prl3a1 UTSW 13 27,459,051 (GRCm39) splice site probably null
R1405:Prl3a1 UTSW 13 27,459,051 (GRCm39) splice site probably null
R1596:Prl3a1 UTSW 13 27,443,600 (GRCm39) start gained probably benign
R1823:Prl3a1 UTSW 13 27,454,177 (GRCm39) missense probably damaging 0.99
R1952:Prl3a1 UTSW 13 27,454,136 (GRCm39) missense possibly damaging 0.91
R2059:Prl3a1 UTSW 13 27,454,127 (GRCm39) missense probably benign 0.13
R5843:Prl3a1 UTSW 13 27,454,093 (GRCm39) missense probably damaging 1.00
R6222:Prl3a1 UTSW 13 27,460,097 (GRCm39) missense probably benign 0.05
R6664:Prl3a1 UTSW 13 27,454,194 (GRCm39) nonsense probably null
R7077:Prl3a1 UTSW 13 27,460,086 (GRCm39) missense probably benign 0.35
R7846:Prl3a1 UTSW 13 27,456,442 (GRCm39) missense probably damaging 1.00
R9049:Prl3a1 UTSW 13 27,460,167 (GRCm39) missense probably damaging 1.00
R9616:Prl3a1 UTSW 13 27,459,118 (GRCm39) missense
Posted On 2015-04-16