Incidental Mutation 'IGL02648:Aadacl4'
ID302040
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Aadacl4
Ensembl Gene ENSMUSG00000070609
Gene Namearylacetamide deacetylase like 4
SynonymsGm13177
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #IGL02648
Quality Score
Status
Chromosome4
Chromosomal Location144613707-144623398 bp(+) (GRCm38)
Type of Mutationcritical splice acceptor site
DNA Base Change (assembly) A to T at 144617822 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000092087 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094510]
Predicted Effect probably null
Transcript: ENSMUST00000094510
SMART Domains Protein: ENSMUSP00000092087
Gene: ENSMUSG00000070609

DomainStartEndE-ValueType
transmembrane domain 7 28 N/A INTRINSIC
transmembrane domain 43 60 N/A INTRINSIC
Pfam:Abhydrolase_3 115 285 9.6e-30 PFAM
Pfam:Abhydrolase_3 272 381 4.9e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp4 A G 7: 44,254,990 probably benign Het
Adgrv1 A T 13: 81,511,619 M1997K probably benign Het
Arhgdib T C 6: 136,933,649 D38G probably damaging Het
Bbox1 T G 2: 110,305,526 D36A probably damaging Het
Cacna1c T C 6: 118,757,496 K104R probably damaging Het
Cacna1i G A 15: 80,298,638 C75Y probably damaging Het
Ccdc14 T C 16: 34,697,158 L70S probably damaging Het
Ccdc88a T G 11: 29,501,051 V1580G probably benign Het
Cdadc1 C A 14: 59,586,363 D227Y probably damaging Het
Chd3 T C 11: 69,352,150 Y1415C probably damaging Het
Cngb3 A G 4: 19,428,489 N493S probably benign Het
Dock10 T A 1: 80,574,123 Y665F probably damaging Het
Gm10549 C A 18: 33,464,250 probably benign Het
Gm17677 A T 9: 35,741,109 M21L probably benign Het
Greb1 C T 12: 16,708,682 V678M probably damaging Het
Gucy2c G A 6: 136,729,213 R497* probably null Het
Itgad T C 7: 128,183,374 probably benign Het
Lgr4 C A 2: 110,012,373 T877K probably damaging Het
Lrig3 A G 10: 125,966,594 D40G probably benign Het
Myo3b T C 2: 70,105,372 probably benign Het
Neb A G 2: 52,271,081 Y2193H possibly damaging Het
Olfr1270 T A 2: 90,149,353 I218F possibly damaging Het
Olfr918 T C 9: 38,673,016 M143V probably benign Het
Pard6b A G 2: 168,098,927 Q278R probably benign Het
Pkd2l1 T C 19: 44,155,536 Y366C possibly damaging Het
Prl2c1 A G 13: 27,857,559 D188G probably benign Het
Prl3a1 G T 13: 27,270,235 M65I probably benign Het
Psg26 T A 7: 18,482,766 E49D probably benign Het
Rapgef3 G A 15: 97,758,392 R38W probably damaging Het
Rrn3 T C 16: 13,811,589 F590L probably benign Het
Serpina12 T C 12: 104,038,008 K122E probably benign Het
Slc39a6 T C 18: 24,582,367 I699V probably damaging Het
Tmem259 G A 10: 79,977,817 P443S probably damaging Het
Vmn1r75 T A 7: 11,881,164 F274L probably benign Het
Other mutations in Aadacl4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02836:Aadacl4 APN 4 144623212 missense possibly damaging 0.79
IGL02949:Aadacl4 APN 4 144617920 missense probably damaging 1.00
IGL03253:Aadacl4 APN 4 144623288 missense probably benign 0.05
white_rabbit UTSW 4 144618028 missense probably benign 0.03
R0035:Aadacl4 UTSW 4 144617941 missense probably damaging 0.98
R0268:Aadacl4 UTSW 4 144622995 missense probably benign 0.00
R1427:Aadacl4 UTSW 4 144623040 missense probably damaging 1.00
R1672:Aadacl4 UTSW 4 144623319 nonsense probably null
R2220:Aadacl4 UTSW 4 144618002 missense probably damaging 0.98
R2353:Aadacl4 UTSW 4 144623209 missense probably damaging 1.00
R2983:Aadacl4 UTSW 4 144623214 missense probably damaging 0.98
R4708:Aadacl4 UTSW 4 144623329 missense probably benign 0.01
R4878:Aadacl4 UTSW 4 144613845 missense possibly damaging 0.62
R4911:Aadacl4 UTSW 4 144613792 missense probably damaging 1.00
R5208:Aadacl4 UTSW 4 144617828 missense probably benign 0.04
R5237:Aadacl4 UTSW 4 144623280 nonsense probably null
R5568:Aadacl4 UTSW 4 144622794 missense probably benign 0.03
R5633:Aadacl4 UTSW 4 144618028 missense probably benign 0.03
R5817:Aadacl4 UTSW 4 144622927 missense probably benign 0.04
R5848:Aadacl4 UTSW 4 144617858 missense probably benign 0.11
R5916:Aadacl4 UTSW 4 144622980 missense possibly damaging 0.93
R6736:Aadacl4 UTSW 4 144623339 missense possibly damaging 0.82
R6814:Aadacl4 UTSW 4 144623180 missense probably benign 0.07
R6872:Aadacl4 UTSW 4 144623180 missense probably benign 0.07
R6971:Aadacl4 UTSW 4 144622733 missense probably damaging 1.00
R6994:Aadacl4 UTSW 4 144623279 missense probably damaging 1.00
R7074:Aadacl4 UTSW 4 144613863 missense probably benign
R7353:Aadacl4 UTSW 4 144617920 missense probably damaging 1.00
R7837:Aadacl4 UTSW 4 144617977 missense probably damaging 1.00
R7853:Aadacl4 UTSW 4 144618022 missense probably benign 0.02
R8120:Aadacl4 UTSW 4 144622890 missense probably benign 0.44
X0017:Aadacl4 UTSW 4 144623016 missense probably damaging 1.00
X0065:Aadacl4 UTSW 4 144623109 missense probably benign 0.00
Posted On2015-04-16