Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02649:Vmn2r23'

302043

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

IGL02649

Quality Score

Status

Chromosome

Chromosomal Location

123702821-123742291 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 123704478 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 115 (M115T)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

probably benign
Transcript: ENSMUST00000172391
AA Change: M115T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: M115T

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aanat	A	T	11: 116,595,646	I4F	probably benign	Het
Adamts17	T	G	7: 66,849,878		probably benign	Het
Adcy1	A	T	11: 7,167,156	M1008L	probably damaging	Het
Atp2a3	C	A	11: 72,975,339	H262N	probably benign	Het
Atrnl1	T	G	19: 57,650,441		probably benign	Het
Brd3	T	A	2: 27,454,350	E456V	probably damaging	Het
Cabin1	A	T	10: 75,737,418	L712H	probably damaging	Het
Ccna1	T	A	3: 55,054,386	T38S	probably damaging	Het
Chadl	T	A	15: 81,695,858	I59F	probably benign	Het
Chmp3	T	C	6: 71,552,433	M27T	possibly damaging	Het
Clcn1	C	T	6: 42,298,829	T295I	probably damaging	Het
Col6a6	A	G	9: 105,727,170		probably null	Het
Dennd2a	T	A	6: 39,470,356	H776L	probably benign	Het
Dimt1	G	A	13: 106,948,711	R55K	probably benign	Het
Dlg5	T	A	14: 24,146,251	D1626V	probably damaging	Het
Dock10	T	A	1: 80,574,123	Y665F	probably damaging	Het
Hectd4	T	C	5: 121,349,402	S3487P	possibly damaging	Het
Hivep1	T	C	13: 42,157,311	V1009A	possibly damaging	Het
Ifna12	A	T	4: 88,602,854	V152E	probably damaging	Het
Igf2r	A	T	17: 12,712,087	C903S	possibly damaging	Het
Ipo9	T	C	1: 135,385,934	D1002G	possibly damaging	Het
Isyna1	T	C	8: 70,596,254	S328P	probably damaging	Het
Lamc1	G	A	1: 153,247,042	T764I	possibly damaging	Het
Lta4h	T	C	10: 93,472,969	V377A	probably benign	Het
Lyz2	C	T	10: 117,282,185	V20I	probably benign	Het
Myo3a	A	T	2: 22,323,607	L329F	probably benign	Het
Nlgn2	T	C	11: 69,825,802	T638A	probably benign	Het
Oasl2	A	G	5: 114,897,692	T10A	probably damaging	Het
Olfr173	T	A	16: 58,797,350	R165S	probably damaging	Het
Olfr761	A	T	17: 37,952,973	F17Y	probably damaging	Het
Pde10a	A	T	17: 8,953,772	N296I	probably damaging	Het
Plb1	A	G	5: 32,362,568	I1385M	probably benign	Het
Pld1	T	C	3: 28,087,229	V647A	probably damaging	Het
Pnp	T	C	14: 50,947,846		probably benign	Het
Ppl	A	T	16: 5,087,463	I1656K	probably damaging	Het
Rimbp3	G	T	16: 17,209,608	E299*	probably null	Het
Sbsn	C	A	7: 30,753,258	A566D	probably damaging	Het
Sh3rf1	T	A	8: 61,363,191	M494K	probably damaging	Het
Slc2a2	T	A	3: 28,718,736	V226E	probably damaging	Het
Smarca2	T	A	19: 26,640,586	I339N	possibly damaging	Het
Ssfa2	T	C	2: 79,641,959		probably benign	Het
Tenm2	G	T	11: 36,207,085	S445R	possibly damaging	Het
Tmem136	C	A	9: 43,111,488	K190N	probably benign	Het
Tnip2	A	T	5: 34,513,731	L56Q	probably damaging	Het
Trpv1	C	T	11: 73,250,786	S485F	probably damaging	Het
Zbtb38	G	A	9: 96,686,619	T804I	probably damaging	Het
Zfhx3	T	C	8: 108,793,535	S430P	possibly damaging	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123729725	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123729596	missense	probably benign
IGL01073:Vmn2r23	APN	6	123712800	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123704424	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123704407	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123741886	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123741860	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123741744	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123741836	missense	probably benign	0.10
IGL02831:Vmn2r23	APN	6	123704385	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123704396	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123741619	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123741782	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123704374	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123729626	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123729721	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123742135	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123742004	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123713270	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123713427	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123729690	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123702915	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123713010	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123741499	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123704425	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123742188	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123713170	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123741389	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123729738	missense	probably benign
R4506:Vmn2r23	UTSW	6	123702925	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123741730	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123741826	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123733349	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123713002	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123733273	missense	probably benign
R5761:Vmn2r23	UTSW	6	123712759	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123733393	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123712942	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123741895	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123704400	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123712902	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123713425	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123733273	missense	probably benign
R6925:Vmn2r23	UTSW	6	123704553	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123713022	missense	probably benign
R7215:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123741581	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123704579	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123704541	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123741353	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123704640	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123741656	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123713472	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123703032	missense
R8966:Vmn2r23	UTSW	6	123742120	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123742079	missense	possibly damaging	0.57
R9163:Vmn2r23	UTSW	6	123741823	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123733393	missense	probably damaging	1.00
R9495:Vmn2r23	UTSW	6	123712713	missense	probably benign	0.30
R9514:Vmn2r23	UTSW	6	123712713	missense	probably benign	0.30
RF018:Vmn2r23	UTSW	6	123713116	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123713161	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123742108	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123729725	frame shift	probably null

Posted On

2015-04-16